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Dresden's Chemical Fluff Thread (Name-A-Molecule)

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Has anyone considered that different enantiomers of a chiral compound have different actions. AMT is a good example. When resolved, only 1 isomer has 5HT2a affinity, the other is just stimulating. I suspect that 6,a-DMT would produce entactogenic activity. 6,a,a,-TMT (achiral) is another interesting one.
 

Gaffy

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Has anyone considered that different enantiomers of a chiral compound have different actions. AMT is a good example. When resolved, only 1 isomer has 5HT2a affinity, the other is just stimulating. I suspect that 6,a-DMT would produce entactogenic activity. 6,a,a,-TMT (achiral) is another interesting one.
Actually I'm quite tweaked and am trying to figure it out for FACAP, 4F-Phenyl-1-CycloPentyl-(2-Methyleminate) and can't select chirals on my mobile phone on STP. Would you point it out with this given example?
 

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Actually I'm quite tweaked and am trying to figure it out for FACAP, 4F-Phenyl-1-CycloPentyl-(2-Methyleminate) and can't select chirals on my mobile phone on STP. Would you point it out with this given example?
STP = DOM? Yes. That would be an excellent example. The example I would really like to test is DON. 2CN is described as 'tofu' and I suspect (R) DON would be similar. You will note that the PEAs are part of the structure of LSD. I HAVE tried the optically resolved AMT but mechanical losses made it expensive. If one was to make 6-methyl AMT, the 6-Me would provide a convenient 'metabolic handle' for the liver to oxidize and thus remove the metabolite. The PEAs & tryptamines overly with the para position of the PEAs overlaying the 6-position of tryptamines. I suggested to Dr. Dave that 3-Me LSD might be interesting and although interested, he baulked at the synthesis.


So often we think about compounds that will never be made due to the complexity of the synthesis. If I mention something, either I HAVE made it or I know someone who HAS made it. I have poor lab technique so I limit myself to working out synthetic pathways. I think it's important to admit one's limitations.

But yeah.... great example. Of course, there are a limited number of synthetic pathways. There IS a supplier in the UK that allows one to obtain the appropriate nitroalkene/nitroalkane so 1 or 2 (2 is still possibly 1 pot) steps.
 
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