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Opioids Does snorting with nasal hair ruin the effect?

Jekyl Anhydride said:
As if this thread could hold any more, here's some decent OT stuff though:

The human nose can accommodate a dose of 25-500 uL per nostril
Permeability of the posterior portion of the nose is higher than that of the anterior portion
Slowly absorbing drug should be deposited in the anterior part
Fast absorbing drug in the posterior part of the nose

Increase in the mucociliary clearance rate decreases residence or contact time between drug and the epithelium and reduced drug absorption
Bioadhesives or viscocist enhancers may increase the residence time and increase nasal drug absorption
Ciliated epithelium is present in the middle and upper part of the turbinates
Drugs deposited in the posterior part of the nasal cavity are removed more quickly than a drug deposited in the anterior part of the nasal cavity

Transcellular transport Across cell membranes Favors lipophilic molecules
Paracellular transport Through tight junction between cells
Pores limit molecules to less than 1000 daltons
Click to expand...

Yes, though this may beyond the scope of a layman
 
Lorne??? said:
Yes, though this may beyond the scope of a layman
Click to expand...

I imagine one could cherry pick some good facts from it. OD is for things that don't fit in BDD or NPD but still have value. You of all people shouldn't be telling others about post's being too complex, as I recall you have some doozies, which I appreciate BTW.
 
Great post jekyl, if a little technical. Yay education involving drugs, my favorite.
 
Jekyl Anhydride said:
I imagine one could cherry pick some good facts from it. OD is for things that don't fit in BDD or NPD but still have value. You of all people shouldn't be telling others about post's being too complex, as I recall you have some doozies, which I appreciate BTW.
Click to expand...

Don't bite my head off!

I enjoy your posts as well; we both post doozies I guess

That was pretty technical is all I meant, though that went w/out saying.

Keep it up, we can absorb or cherry pick l as needed :)

(Edit: Yours probably a step above mine :) )
 
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