copium7777
Bluelighter
- Joined
- Apr 26, 2020
- Messages
- 411
The reason I ask is obvious. Ibogaine is well known for totally "resetting " opioid tolerance, and is a kappa opioid agonist, with some similar subjective effects to salvia, which contains the kappa opioid agonists salvinorin a.
However ibogaine is known to have negative effects in the heart and as far as I know salvia isnt (although I suppose it hasn't been studied enough to say for sure ).
Also it seems kappa opioid agonists have some analgesic effect on their own even though they are dissociative and dysphoric rather than euphoric like mu agonists.
The reason I'm interested is bc I'm a chronic pain patient. A drug that could reset opioid tolerance could really be useful as one of the main problems with opioid therapy for chronic pain is that it causes dependence and loses efficacy fast at moderate doses.
So obviously unlike someone who has addiction problems that are devastating but otherwise is physically healthy the cost benefit with iboga heart side effects is not worth it if my use wouldn't be to "turn my life around " but merely to periodically reset opioid receptors.
However ibogaine is known to have negative effects in the heart and as far as I know salvia isnt (although I suppose it hasn't been studied enough to say for sure ).
Also it seems kappa opioid agonists have some analgesic effect on their own even though they are dissociative and dysphoric rather than euphoric like mu agonists.
The reason I'm interested is bc I'm a chronic pain patient. A drug that could reset opioid tolerance could really be useful as one of the main problems with opioid therapy for chronic pain is that it causes dependence and loses efficacy fast at moderate doses.
So obviously unlike someone who has addiction problems that are devastating but otherwise is physically healthy the cost benefit with iboga heart side effects is not worth it if my use wouldn't be to "turn my life around " but merely to periodically reset opioid receptors.