Opioids Does Cimetidine potentiate Hydrocodone?

[williamclarkonet]

Does Cimetidine potentiate Hydrocodone? I'm looking only for Hydrocodone potentiate specifically. Thanks for all replies

 

[Kittycat5]

Probably not. Cimetidine is a fairly strong inhibitor of CYP 3A4 which is responsible for metabolizing hydro into an active metabolite norhydrocodone. CYP2D6 is what you need to inhibit to possibly potentiate hydrocodone, and cimetidine is only a weak inhibitor of this isoenzyme.

 

[williamclarkonet]

Thanks your info was fabulous again thanks you!