Do non central acting antihistamines produce tolerance?
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BilZ0r
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Tolerance, no.
dependence/rebound effects, I can't find anything to indicate one way or another, but I doubt it.
What about things like diphenhydramine? Well it's possible that you could get tolerance to some of the recreational effects, but not to the pure anti-histamine effects.
dependence/rebound effects, I can't find anything to indicate one way or another, but I doubt it.
What about things like diphenhydramine? Well it's possible that you could get tolerance to some of the recreational effects, but not to the pure anti-histamine effects.
You will develop a tolerance to antihistamines.
What we normally advise is that you switch between (I'm guessing you like the non-drowsy variety) telfast, claramax, clarityne and zyrtec (somewhat higher incidence of drowsiness though) every 6 weeks.
I'd stay away from the steroidal nose sprays as they ruin the sensitivity of the nose, however if you are a smoker anyway go for your life.
What we normally advise is that you switch between (I'm guessing you like the non-drowsy variety) telfast, claramax, clarityne and zyrtec (somewhat higher incidence of drowsiness though) every 6 weeks.
I'd stay away from the steroidal nose sprays as they ruin the sensitivity of the nose, however if you are a smoker anyway go for your life.
Well if you aren't a pharmacist or doctor it should be news to you. It's common knowledge for pharmacists. If you want to find out the specifics of a study I'd suggest looking through the various online medical journals (medline is a good one). I know that around 6 weeks isn't long enough for significant tolerance to develop. The exact time isn't critical as we are only treating allergies here, as long as chronic sufferers (long-term users) are aware that they will need to rotate between different types.
A quick google search came up with this information verifying my claim (that's all it would have taken to answer his question):
Antihistamines
A quick google search came up with this information verifying my claim (that's all it would have taken to answer his question):
Antihistamines
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BilZ0r
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It's no news to me that 1st generation antihistamines produce tolerance 1, but as far as I was awear no published clinical trial had shown that 2nd generation antihistamines produced subsensitivity. While I am only awear of publications on terfenadine, cetirizine and loratadine, because of the link between terfenadine and fexofenadine, I thought it was reasonable to assume that it would also not produce subsensitivity.
As I said, if you had any references, I would love to be schooled, as histamine is one of the major focuses of the research in my lab.
As I said, if you had any references, I would love to be schooled, as histamine is one of the major focuses of the research in my lab.