Opioids CWE Co-codamol 8/500 - help calculating water needed

[DenisRaymond]

I've done a CWE around 10 times now with 32 8/500mg co-codamol tablets, but I've never been satisfied that I'm using the right amount of water. I usually enjoy a good puzzle, but I've looked at the solubility tables a number of times and always come away more confused/frustrated than informed!

I had thought someone might've put together an online calculator or a simple formula to help work it out, but I've searched and searched and found nothing. So, could anyone either explain how they calculate it themselves, or just let me know how much water I'd need to start with for 32 8/500mg co-codamol tablets? I'm considering bumping up to 38 this time too, as I feel I'm quite tolerant, so any advice/warnings/amounts of water needed for this would also be appreciated.

Cheers,
DR

 

[Slow_Mobius]

It's not terribly important to use a specific amount. There's a dramatic difference in solubility between apap and codeine. I've never done a CWE so I can't say how much people normally use, but calculations are unnecessary.