Jabberwocky
Frumious Bandersnatch
- Joined
- Nov 3, 1999
- Messages
- 84,998
Maybe this has already been shared. Apologies if old news
However for me it’s an interesting use of natural language processing on trip reports and Principal Component Analysis to examine the connection between psychadelic substance receptor affinity, substance molecular structure, and subjective effects in support of hypothesis that many receptor types combine in the (varying) psychedelic experience.
It discussed 42 different receptor locations and 19 different substances broadly categorised as either phenethylamines and tryptamines.
I found it interesting in context of another discussion about minimising SERT binding in medicine choice in order to improve psychadelic experiences when medicated for depresion. Plus it’s a novel research methodology to work around ethical issues with human subjects being administered these substances.
The linked references may also keep some people busy.
www.frontiersin.org
However for me it’s an interesting use of natural language processing on trip reports and Principal Component Analysis to examine the connection between psychadelic substance receptor affinity, substance molecular structure, and subjective effects in support of hypothesis that many receptor types combine in the (varying) psychedelic experience.
It discussed 42 different receptor locations and 19 different substances broadly categorised as either phenethylamines and tryptamines.
I found it interesting in context of another discussion about minimising SERT binding in medicine choice in order to improve psychadelic experiences when medicated for depresion. Plus it’s a novel research methodology to work around ethical issues with human subjects being administered these substances.
The linked references may also keep some people busy.
The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of the user (“set”) and the surroundings...
