plumbus-nine
Bluelighter
- Joined
- Apr 4, 2021
- Messages
- 3,653
Afaik the NMDA receptor is a bit more complex than your usual e.g. mu, in that mu is mainly there to be agonized by endomorphine/endorphine while NMDA is an active ion channel and is involved in many processes like memory, and necessary for normal brain function. Antagonizing it beyond a certain degree will lead to unconsciousness*. So it might be more sensitive to mixing antagonists with differing kinetics or even sites, like e.g. DXM/O & memantine, or K & memantine, or K & DXM.
Strangely many people combine dissociatives with good results, including myself in early years but with increased tolerance I began to get weird, really weird sensory features like seemingly random, yet reproduceable artifacts in vision (DXM) or blubbing noise distortion (memantine & ACH). Mem & DXM were good together many years ago, didn't try in recent times. One might well label it psychotomimetic, yeah I know dissos themselves carry this label but that's mainly from PCP(?) which is a bit unique and has been very poorly dosed by dipping cigs in solution.. there are huge differences between what's labelled as psychosis, as well as between disso-induced mental state, toxic psychosis, and psychedelis. The first and the last have more in common than the second even when all are vasty different. This was most present with memantine & other agent, DXM & other agent and mostly absent when mixing non-3-HO arylcyclohexylamines.
So what's the deal with mixing NMDA antagonists? Strange? To avoid? Dangerous?
Thinking about getting some DXM as a booster for memantine, because I feel its D2 agonism at low doses where the dissociative effects are mostly absent and don't wanna waste it.. but also psychosis once was enough.
* I've read that K has a dual mechanism, and that it isn't even the NMDA antagonism but something GABAergic(?) which causes anesthesia with it but all the dissociatives are anesthetics when "overdosed" and with a remarkable safety. Personally watched a MXE overdose who just slept it off, and later on the hunt for the hole (which I never ever reached in like 10 years) I've anesthesized myself countless times with some confusion being all I got..
Strangely many people combine dissociatives with good results, including myself in early years but with increased tolerance I began to get weird, really weird sensory features like seemingly random, yet reproduceable artifacts in vision (DXM) or blubbing noise distortion (memantine & ACH). Mem & DXM were good together many years ago, didn't try in recent times. One might well label it psychotomimetic, yeah I know dissos themselves carry this label but that's mainly from PCP(?) which is a bit unique and has been very poorly dosed by dipping cigs in solution.. there are huge differences between what's labelled as psychosis, as well as between disso-induced mental state, toxic psychosis, and psychedelis. The first and the last have more in common than the second even when all are vasty different. This was most present with memantine & other agent, DXM & other agent and mostly absent when mixing non-3-HO arylcyclohexylamines.
So what's the deal with mixing NMDA antagonists? Strange? To avoid? Dangerous?
Thinking about getting some DXM as a booster for memantine, because I feel its D2 agonism at low doses where the dissociative effects are mostly absent and don't wanna waste it.. but also psychosis once was enough.
* I've read that K has a dual mechanism, and that it isn't even the NMDA antagonism but something GABAergic(?) which causes anesthesia with it but all the dissociatives are anesthetics when "overdosed" and with a remarkable safety. Personally watched a MXE overdose who just slept it off, and later on the hunt for the hole (which I never ever reached in like 10 years) I've anesthesized myself countless times with some confusion being all I got..
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