Opioids codein x tramadol

[xtrip]

there is any difference between the effects of tramadol and codeine? also any difference between Codein x codeine phosphate + paracetamol ( after cold water extraction )

 

[darvocet21]

there is any difference between the effects of tramadol and codeine? also any difference between Codein x codeine phosphate + paracetamol ( after cold water extraction )

Yes. One is synthetic and one is natural and it's a lot of other differences too

I don't get the second part of your question

 

[emkee_reinvented]

Lot s of em. Most important one is the seizure risk of Tramadol when the dosage exceed's about 400 mg a day, not in one go.

Codein is warmer shorter and more sedating imo.

 

[tubgirl.jpg]

Yeah. Tramadol acts as an opiod combined with an SNRI. Codeine is "just" an opiate. Tramadol has a more stimulating high.

 

[WellTram]

Codeine is an opiate and prodrug of morphine used to treat pain, coughing, and diarrhea. It is found naturally in the sap of the opium poppy, Papaver somniferum.
*It is typically used to treat mild to moderate degrees of pain.
*it is metabolized by CYP2D6 do morphine ( 5-10, maybe 15 percent of ingested dose, according to your genotype), by CYP3A4 to norcodeine and by UGT2B7 to glucuronides of codeine, norcodeine, and morphine
*it has elimination half-life of about 3 hours, duration of action 3-6 hours
*it can be VERY itchy, warm and generally sedating
*onset of action approximately 1 hour(30-120minutes)
*bioavailability of oral ROA ~90%

Tramadol is an opioid pain medication used to treat moderate to moderately severe pain.
* metabolized by CYP2D6 to its main opiod-active metabolite O-desmethyltramadol, by CYP3A4 to N-desmethyltramadol.
* it acts as an SERORONINE-NOREPINEPHRINE reuptake inhibitor, which every metabolite and enenatiomer shares different SRI or NRI potency. It also has many different actions such as weak NMDA receptor antagonist etc.
* Its bioavailability is approximately 75 percent but raises if u ingest it in a way of staggering your doses.
* Its half-life 6.3 ± 1.4 also increase with dose staggering.
* Generally much longer acting, less sedating (sometimes even stimulant) than codeine but it also has some itching-potential.
* Onset of action is most of the time lomger than codeins, full effects at 2-3 hours.
* Not recommended to dose more than 100mg at once and more than 400mg daily because of higly increased risk of (very unpleasant and dangeroes) seizures.
* Antidepressant-like activity (instant)
* More prove to nausea than codeine...

Not sure if i forgot somthing..they are both casually combined with paracetamol so be careful, spread your doses (mainly with tramadol) and u will also spare your liver.

 

[Leam1312]

Codeine is an opiate and prodrug of morphine used to treat pain, coughing, and diarrhea. It is found naturally in the sap of the opium poppy, Papaver somniferum.
*It is typically used to treat mild to moderate degrees of pain.
*it is metabolized by CYP2D6 do morphine ( 5-10, maybe 15 percent of ingested dose, according to your genotype), by CYP3A4 to norcodeine and by UGT2B7 to glucuronides of codeine, norcodeine, and morphine
*it has elimination half-life of about 3 hours, duration of action 3-6 hours
*it can be VERY itchy, warm and generally sedating
*onset of action approximately 1 hour(30-120minutes)
*bioavailability of oral ROA ~90%

Tramadol is an opioid pain medication used to treat moderate to moderately severe pain.
* metabolized by CYP2D6 to its main opiod-active metabolite O-desmethyltramadol, by CYP3A4 to N-desmethyltramadol.
* it acts as an SERORONINE-NOREPINEPHRINE reuptake inhibitor, which every metabolite and enenatiomer shares different SRI or NRI potency. It also has many different actions such as weak NMDA receptor antagonist etc.
* Its bioavailability is approximately 75 percent but raises if u ingest it in a way of staggering your doses.
* Its half-life 6.3 ± 1.4 also increase with dose staggering.
* Generally much longer acting, less sedating (sometimes even stimulant) than codeine but it also has some itching-potential.
* Onset of action is most of the time lomger than codeins, full effects at 2-3 hours.
* Not recommended to dose more than 100mg at once and more than 400mg daily because of higly increased risk of (very unpleasant and dangeroes) seizures.
* Antidepressant-like activity (instant)
* More prove to nausea than codeine...

Not sure if i forgot somthing..they are both casually combined with paracetamol so be careful, spread your doses (mainly with tramadol) and u will also spare your liver.

You need to put the codeine under the lip and once its dissolved its morphine

 

[darvocet21]

You need to put the codeine under the lip and once its dissolved its morphine

No can do. I think only 10% is converted to morphine after first-pass metabolism. Depending on your tolerance you need roughly 15 to 60mg morphine to get an effect. So 150 to 600mg codeine under your tongue will give you a pasty mouth not much more until you swish and swallow