I was prescribed to both of these medications for quite some time and I did not have any issues. I was prescribed 1mg of Xanax four times a day and 0.2mg of Clonidine at night. I would always take my last 1mg of Xanax and the 0.2mg of Clonidine together before bed and I never had any issues. However, I would still recommend you consult a doctor/professional.