Chemical & Engineering News: Weekly highlights

[polymath]

^ Separate this part from ubrogepant and it looks like it could be a stimulant drug...

SwissTargetPrediction

www.swisstargetprediction.ch

 

[S.J.B.]

January 27, 2020:

How a stress chemical turns mouse hair gray

 

[hydroazuanacaine]

View attachment 20998
Xcopri (cenobamate), for partial-onset seizures

has anyone taken this? i just saw an online ad for it.

Cenobamate is an investigational antiepileptic drug with a unique dual mechanism of action: it acts via the reduction of persistent currents through voltage-gated sodium channels and positive allosteric modulation of GABAA receptors at the non-benzodiazepine binding site. (source)

so it acts like a gabapentinoid. or maybe like lamotrigine? trying to find an article that says if cenobamate acts on the α2δ subunits like gabapentinoids. plus the gabaA modulation.

it's schedule v. wonder how the high compares to pregabalin.