What worries me about levodopa is that not only in Parkinson's (where the illness might be responsible for) but also in RLS,
people seem to develop lasting tolerance, dyskinesia etc. even though I don't see why L-dopa should be worse than xenobiotic agonists like pramipexole. Maybe it's because of different binding profile, but still a meth binge should involve much more dopamine than any therapeutic use of L-dopa and in my experience stims, when not over-used, aren't so bad. Also memantine, being a D2 agonist, didn't cause PAWS/DAWS for me but there are a handful cases who got it..
Any info about whether it's primarily a problem with certain disorders involving degradation of dopamine production or does L-dopa always cause a lasting impact? Why is it worse than stims?
Edit:
Wikipedia suggests that it's related to D1, which most agonists don't touch. Also in PD dyskinesia occurs after 5-10 years, so that short(er) term use might be safe. Levetiracetam and amantadine seem to aid against but dunno whether just masking or actually preventing. Anticholinergics used against tardive dyskinesia just mask the symptoms but these might well have another cause.