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Bupe Bupe / sub bioavailability in relation to tolerance, tapering, and WD symptoms.

pornstache

Greenlighter
Joined
Sep 23, 2015
Messages
4
I was googling bupe bioavailibility and it says SL is only 29% available relative to IV ROA.

So after years of IVing bupe, if someone were to switch to SL ROA, and maintaing the same daily dosage, this would be equivalent to someone who only ever IVs cutting their dose by 70%?

I was originally doing approximately one 8mg tablet per day, spread over 2-4 shots, sometimes more if I didn't get a good hit (always with filters and 31g); but accounting for losses in the extraction process, holdup in the filter, etc., it probably drops the amount down a bit. Regardless, lets say I was doing 8mg and now I am doing the same 8mg but taking as directed. Since I switched I have been having WD symptoms, but mild ones, during the day. Specifically sweating from under the arms, so as to cause single drops of sweat to tricke down my sides, randomly throughout the day. Honestly it seems benign compared to other WD symptoms but it is driving me fucking crazy. Also i am having trouble sleeping, I keep waking throughout the night and have trouble getting deep sleep.

Mainly I want to know if the numbers regarding the bio-availability relate to tolerance as well as euphoric effect? Am I now only getting 30% of the drug vis-a-vis my tolerace? Or is bioavailibity just relating to the high? If it is both, that means that someone going from IV to SL would have to triple their dose to get the same narcotic effect, correct?

If that is true, I would rather not do that, since I ultimately want to get the fuck off this stuff for good. If I stay at this dose, how long will it take for the WD symptoms to go away, so I am back to the place I was at (tolerance-wise) when I was IVing?

I have read that many people don't have issues cutting their dose down when they are still taking a relatively large dose (less-is-more philosophy), but the sweating is similar to what used to happen when I was tapering a methadone dose down to the single digits, however it was only the beginning. I don't know if I can deal with that kind of WDs every day for months or years...

Any help is greatly appreciated!
 
Bioavailability is a measure of how much drug reaches the bloodstream after a dose. Normally you would be correct in assuming that if a drug is 29% BA SL vs IV you would need roughly 3 times the dose to get same effects, both positive and negative, but bupe has a ceiling effect somewhere between 8-16mg SL. Converting this to IV, it would seem 2.5 to 5mg IV could reach this same effect. It is likely that your repeated doses of IV bupe may have not produced much of any effect, since bupe binds tighthly and for a long time to the receptor, as well as the effect mentioned but I am speculating there. But I would not triple the dose to 24 mg when now using it SL, only go to a max of 16mg.
 
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