So I have always been intrigued by the relationship bupes effects have with its metabolite norbupe. Basically, if it's metabolized by 3A4 cyto, would an elevated amount of said cytochrome mean more metabolized norbupe, and therefore also more full agonist effect? Also, how much does it really affect the person, especially depending on dependency and tolerance, dose, etc.
So obviously this is a bit of neuroscience but being a sub dependent person and naturally curious about this sort of thing, I came across some info regarding p-glycoproteins and norbupe. Basically, they transfer out norbupe similar to the way they do loperamide, though probably to a much lesser extent.
So I know there are ways a very, VERY determined person can coat lope in nano-particled polysorbate 80 and crap to make it active by bypassing the protein transfers and stuff, so I am wondering if anyone knows of the extent norbupe is active or effected by glycoproteins? And would there be a way to lessen this, or would it even be worth it?
I assume not, but I am basically bringing this up for the intellectual discussion. I find it interesting, especially considering how complex the effect profile of bupe is even without considering norbupe anyway. I'll probably edit this with crap I forgot.
Any thoughts?
So obviously this is a bit of neuroscience but being a sub dependent person and naturally curious about this sort of thing, I came across some info regarding p-glycoproteins and norbupe. Basically, they transfer out norbupe similar to the way they do loperamide, though probably to a much lesser extent.
So I know there are ways a very, VERY determined person can coat lope in nano-particled polysorbate 80 and crap to make it active by bypassing the protein transfers and stuff, so I am wondering if anyone knows of the extent norbupe is active or effected by glycoproteins? And would there be a way to lessen this, or would it even be worth it?
I assume not, but I am basically bringing this up for the intellectual discussion. I find it interesting, especially considering how complex the effect profile of bupe is even without considering norbupe anyway. I'll probably edit this with crap I forgot.
Any thoughts?