Supposedly this material has appeared on the market, there appears to be a lack of even basic research literature search by those promoting this substance. this thread is for discussion of the science anything off topic will be deleted.
This on the face of it does not look good, especially for a dopaminergic drug which due to its very nature encourages repeat dosing.
Psychopharmacology (1999) 145:370–377
occasional moderate use is probably harmless, I know several people who have taken it a few times up to 25mg without serious adverse effects, however the risk is with repeat dosing or longer term use.
The compound appears to exert hepatotoxicity, which is most likely attributable to the benzothiophene moety. which probably becomes oxidised to a S oxide, Similar compounds are known hepatotoxins and medicines with this property are used with liver function monitoring. see Zileuton http://en.wikipedia.org/wiki/Zileuton
This on the face of it does not look good, especially for a dopaminergic drug which due to its very nature encourages repeat dosing.
Psychopharmacology (1999) 145:370–377
Toxic effects of BTCP
During initial studies, we began training a group of six
rats to discriminate 10 mg/kg BTCP from saline; however,
one animal died after approximately 50 training sessions
(approximately 20 BTCP injections spaced according
to the sequences listed in Methods) and a similar premorbid
state (excessive weight loss and abdominal tenderness)
was observed in the five remaining animals.
Necropsies were performed on all of the animals, and the
findings indicated that death and morbidity were associated
with gastrointestinal effects, such as adhesive peritonitis,
ileitis, and encapsulation of the liver. Histological
findings confirmed the existence of severe chronic peritonitis
associated with mesenteric lymphadenopathy. Although
we then began using a lower training dose in
drug-naive rats, it was observed subsequently that these
animals did not live as long after repeated administration
of the lower training dose as did rats used for other discriminations
in our laboratory.
Survival analysis using the number of sessions conducted
with rats trained to discriminate BTCP (5 mg/kg)
or cocaine (10 mg/kg) indicated that BTCP-trained rats
were used for a significantly smaller number of sessions
(C2=15, P<0.001) than cocaine-trained rats (204±42
days vs 403±65 days; BTCP vs cocaine, respectively).
occasional moderate use is probably harmless, I know several people who have taken it a few times up to 25mg without serious adverse effects, however the risk is with repeat dosing or longer term use.
The compound appears to exert hepatotoxicity, which is most likely attributable to the benzothiophene moety. which probably becomes oxidised to a S oxide, Similar compounds are known hepatotoxins and medicines with this property are used with liver function monitoring. see Zileuton http://en.wikipedia.org/wiki/Zileuton