Etterwonde
Bluelighter
- Joined
- Jan 25, 2010
- Messages
- 73
Greetings, all!
I have been wondering about something. Something that I don't think has ever been thought of (although) I might be wrong, but that may potentially have be used for future applications. I am posting this for two very important reasons, being:
I would like to thank you all in advance, especially those who did not only time to read the whole thing that I wrote, but even better yet: gave me a useful answer.
If certain opioids –Morphine (maybe even Codeine) and/or its metabolites in this particular case– get excreted by breast milk in significant high amounts to be dangerous for an infant, would it be safe to say that an opioid-naive individual could get high from consuming the breast milk of a female with an extremely high tolerance? Because, if this is the case (although this probably wouldn't work for people like myself, due to the fact that I have quite the opioid tolerance myself): now that would be a wonderful way to enjoy a nice opioid/opiate high!
Also, if the tolerant female in question was consuming, let's say, Oxycodone (or another opioid substrate for the involved Cytochrome P450 enzymes... Wouldn't that mean that the opioid-naive person would be consuming other opioids as well, apart from the opioid pro-drug –Oxycodone in this example–, like active (as well as inactive) metabolites, some of which are much more active, like the much higher/better regarded –at least by the vast majority of opioid aficionados– semi-synthetic opioid Oxymorphone. I'm asking this because Oxymorphone is an active metabolite of Oxycodone in a way that is analogous to the metabolic conversion of Codeine into Morphine, Dihydrocodeine into Dihydromorphine, Hydrocodone into Hydromorphone, or even Tilidine into Nortilidine, Tramadol into O-Desmethyltramadol (which, if I remember this correct, doesn't lower the seizure threshold due to lack of SNRI-activity), Buprenorphine into Norbuprenorphine (which acts as a full agonist on the opioid µ-receptor, as opposed to Buprenorphine, which is only a partial agonist and reportedly has a ceiling dose of ~32 milligrams).
This happens due to the endogenous Cytochrome P450 enzymes of the liver, which could also mean that when the opioid tolerant female consumes certain inhibitors of these enzymes, this could increase the concentration of the aforementioned active metabolites in the opioid tolerant woman's breast milk, therefore having breast milk containing some pretty hardcore opioids, especially in people who are opioid-naive!
Also, I know a lot of women bottle their breast milk and keep them in the freezer or store them one way or another. Wouldn't it be feasible to store a whole lot of this breast milk, even storing breast milk of multiple highly or extremely tolerant females over a longer period of time, and then (when slowly thawed) making a more practical concentration of the total amount stored, in order to facilitate easy consumption, all the while being extremely careful as to not ruin the active opioids in the breast milk (avoiding degradation by sunlight, temperature, and what have you not).
There is even colostrum powder, both human and from animals, for sale online (a quick Google search will show you this), so it would surprise me if this wasn't possible. After all, the reason people buy and consume powdered colostrum is because of the healthy molecules it contains, like (among others) a lot of antioxidants, as well as the antibody Immunoglobulin G, which is obviously not destroyed when turning the colostrum as it is excreted by the female, into a powder, hence the popularity of said powder on online reform shops. These are often sold in bulk amounts, usually ranging from up to a few hundred grams to 500 grams and more. Many of the molecules in colostrum are a lot more unstable than most opioid molecules, so again: I really think this is feasible, and I honestly do think I might be onto something here.
Thanks for reading! I'm looking forward to reading your replies about this, because I am correct, I think the implications of this could be enormous (of course, I have thought about ways to make such a thing economically viable, and I bet there are some ways, I even already have a crude idea on how to market "opioid-rich colostrum powder" for use in research).
Best regards,
Etterwonde
I have been wondering about something. Something that I don't think has ever been thought of (although) I might be wrong, but that may potentially have be used for future applications. I am posting this for two very important reasons, being:
- To start a debate, maybe encourage some of you to do your own research and receive some useful feedback;
- To come to a joint conclusion (as a community) and decide whether or not this is something that is worth exploring furter;
- If the above was satisfactory for both me and the community: how we will proceed regarding this topic.
I would like to thank you all in advance, especially those who did not only time to read the whole thing that I wrote, but even better yet: gave me a useful answer.
If certain opioids –Morphine (maybe even Codeine) and/or its metabolites in this particular case– get excreted by breast milk in significant high amounts to be dangerous for an infant, would it be safe to say that an opioid-naive individual could get high from consuming the breast milk of a female with an extremely high tolerance? Because, if this is the case (although this probably wouldn't work for people like myself, due to the fact that I have quite the opioid tolerance myself): now that would be a wonderful way to enjoy a nice opioid/opiate high!
Also, if the tolerant female in question was consuming, let's say, Oxycodone (or another opioid substrate for the involved Cytochrome P450 enzymes... Wouldn't that mean that the opioid-naive person would be consuming other opioids as well, apart from the opioid pro-drug –Oxycodone in this example–, like active (as well as inactive) metabolites, some of which are much more active, like the much higher/better regarded –at least by the vast majority of opioid aficionados– semi-synthetic opioid Oxymorphone. I'm asking this because Oxymorphone is an active metabolite of Oxycodone in a way that is analogous to the metabolic conversion of Codeine into Morphine, Dihydrocodeine into Dihydromorphine, Hydrocodone into Hydromorphone, or even Tilidine into Nortilidine, Tramadol into O-Desmethyltramadol (which, if I remember this correct, doesn't lower the seizure threshold due to lack of SNRI-activity), Buprenorphine into Norbuprenorphine (which acts as a full agonist on the opioid µ-receptor, as opposed to Buprenorphine, which is only a partial agonist and reportedly has a ceiling dose of ~32 milligrams).
This happens due to the endogenous Cytochrome P450 enzymes of the liver, which could also mean that when the opioid tolerant female consumes certain inhibitors of these enzymes, this could increase the concentration of the aforementioned active metabolites in the opioid tolerant woman's breast milk, therefore having breast milk containing some pretty hardcore opioids, especially in people who are opioid-naive!
Also, I know a lot of women bottle their breast milk and keep them in the freezer or store them one way or another. Wouldn't it be feasible to store a whole lot of this breast milk, even storing breast milk of multiple highly or extremely tolerant females over a longer period of time, and then (when slowly thawed) making a more practical concentration of the total amount stored, in order to facilitate easy consumption, all the while being extremely careful as to not ruin the active opioids in the breast milk (avoiding degradation by sunlight, temperature, and what have you not).
There is even colostrum powder, both human and from animals, for sale online (a quick Google search will show you this), so it would surprise me if this wasn't possible. After all, the reason people buy and consume powdered colostrum is because of the healthy molecules it contains, like (among others) a lot of antioxidants, as well as the antibody Immunoglobulin G, which is obviously not destroyed when turning the colostrum as it is excreted by the female, into a powder, hence the popularity of said powder on online reform shops. These are often sold in bulk amounts, usually ranging from up to a few hundred grams to 500 grams and more. Many of the molecules in colostrum are a lot more unstable than most opioid molecules, so again: I really think this is feasible, and I honestly do think I might be onto something here.
Thanks for reading! I'm looking forward to reading your replies about this, because I am correct, I think the implications of this could be enormous (of course, I have thought about ways to make such a thing economically viable, and I bet there are some ways, I even already have a crude idea on how to market "opioid-rich colostrum powder" for use in research).
Best regards,
Etterwonde
