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News Bluelight Research on Ketamine as a Treatment for Depression and PTSD

Bluelight Research on Ketamine as a Treatment for Depression and PTSD


Bluelight would like to congratulate Tharcila Chaves and her colleagues on their recent publication: The use of ketamine to cope with depression and post-traumatic stress disorder: A qualitative analysis of the discourses posted on a popular online forum. The paper was published in The American Journal of Drug and Alcohol Abuse.


The abstract is quoted below:

Background
Because of the shortcomings of traditional pharmacotherapy for major depressive disorder and post-traumatic stress disorder (PTSD), there has been growing interest in the rapid mood-enhancing effect of ketamine.

Objectives
To analyze what has been posted about ketamine use for dealing with self-reported depression and/or PTSD on one of the biggest international message boards on the internet.

Methods
Qualitative study with online observation of threaded discussions on Bluelight. In-depth online searches were conducted in 2018. Twenty-nine threads, with a total of 708 units of analysis, were selected and subjected to content analysis, where, via a coding process, the units of analysis were organized into nodes.

Results
Despite having several negative effects (e.g. dizziness, nausea and inability to talk), the examined discourses suggested that the use of ketamine to elevate mood was both efficient and worthwhile. Intranasal use was the most common route of administration mentioned. We traced how the mood enhancement caused by ketamine is perceived: the loss of pleasure disappears, as well as the depressed mood; the markedly diminished interest in activities vanishes and motivation comes back. From all the posts analyzed, only two reported negative outcomes (i.e. no mood-enhancing effect). The most mentioned adverse event was damage to the urinary bladder and the kidneys in cases of misuse.

Conclusion
Although online research of user-generated content has its limitations in terms of reliability and validity, the present study adds relevant information on the use of ketamine for managing depression and PTSD, whether this use is done legally or not.



Annotated version of the final paragraph in the conclusion of the article is quoted below:

Ketamine appears to be a potential tool in managing depressive symptoms. The increasing popularity of ketamine clinics and the FDA approval of esketamine for TRD (treatment resistant depression) say a lot about the current status of off-label ketamine: it seems to work in several situations and people are already benefiting from it (not only people living with depression or PTSD; another popular off-label use of ketamine is for treating chronic pain). Ketamine has the potential to benefit a big group of patients who do not respond to the available therapies. It is considered by the World Health Organization an essential medicine and restricting it has harmed patients, with no reduction in recreational use. More scientific research is needed, naturally, but there is already a substantial amount of data suggesting that ketamine is effective and safe. “If they don’t bring us the treatment, we will make it ourselves”, a T1 member stated (Bluelight quote from thread no. 1). From the black market to the white coat, ketamine as a mood enhancer has been presenting positive results in handling depression and PTSD, giving a novel approach to the pathophysiology and therapy of these conditions.


I think we should be proud to have contributed to an article that advocated greater availability of ketamine as a medicine for depression and PTSD. :)


Note that the full-text article is behind a paywall, but if you have issues accessing and want the pdf, send an email to [email protected]
 
Bluelight Research on Ketamine as a Treatment for Depression and PTSD


Bluelight would like to congratulate Tharcila Chaves and her colleagues on their recent publication: The use of ketamine to cope with depression and post-traumatic stress disorder: A qualitative analysis of the discourses posted on a popular online forum. The paper was published in The American Journal of Drug and Alcohol Abuse.


The abstract is quoted below:

Background
Because of the shortcomings of traditional pharmacotherapy for major depressive disorder and post-traumatic stress disorder (PTSD), there has been growing interest in the rapid mood-enhancing effect of ketamine.

Objectives
To analyze what has been posted about ketamine use for dealing with self-reported depression and/or PTSD on one of the biggest international message boards on the internet.

Methods
Qualitative study with online observation of threaded discussions on Bluelight. In-depth online searches were conducted in 2018. Twenty-nine threads, with a total of 708 units of analysis, were selected and subjected to content analysis, where, via a coding process, the units of analysis were organized into nodes.

Results
Despite having several negative effects (e.g. dizziness, nausea and inability to talk), the examined discourses suggested that the use of ketamine to elevate mood was both efficient and worthwhile. Intranasal use was the most common route of administration mentioned. We traced how the mood enhancement caused by ketamine is perceived: the loss of pleasure disappears, as well as the depressed mood; the markedly diminished interest in activities vanishes and motivation comes back. From all the posts analyzed, only two reported negative outcomes (i.e. no mood-enhancing effect). The most mentioned adverse event was damage to the urinary bladder and the kidneys in cases of misuse.

Conclusion
Although online research of user-generated content has its limitations in terms of reliability and validity, the present study adds relevant information on the use of ketamine for managing depression and PTSD, whether this use is done legally or not.



Annotated version of the final paragraph in the conclusion of the article is quoted below:

Ketamine appears to be a potential tool in managing depressive symptoms. The increasing popularity of ketamine clinics and the FDA approval of esketamine for TRD (treatment resistant depression) say a lot about the current status of off-label ketamine: it seems to work in several situations and people are already benefiting from it (not only people living with depression or PTSD; another popular off-label use of ketamine is for treating chronic pain). Ketamine has the potential to benefit a big group of patients who do not respond to the available therapies. It is considered by the World Health Organization an essential medicine and restricting it has harmed patients, with no reduction in recreational use. More scientific research is needed, naturally, but there is already a substantial amount of data suggesting that ketamine is effective and safe. “If they don’t bring us the treatment, we will make it ourselves”, a T1 member stated (Bluelight quote from thread no. 1). From the black market to the white coat, ketamine as a mood enhancer has been presenting positive results in handling depression and PTSD, giving a novel approach to the pathophysiology and therapy of these conditions.


I think we should be proud to have contributed to an article that advocated greater availability of ketamine as a medicine for depression and PTSD. :)


Note that the full-text article is behind a paywall, but if you have issues accessing and want the pdf, send an email to [email protected]
Bluelight Research on Ketamine as a Treatment for Depression and PTSD


Bluelight would like to congratulate Tharcila Chaves and her colleagues on their recent publication: The use of ketamine to cope with depression and post-traumatic stress disorder: A qualitative analysis of the discourses posted on a popular online forum. The paper was published in The American Journal of Drug and Alcohol Abuse.


The abstract is quoted below:

Background
Because of the shortcomings of traditional pharmacotherapy for major depressive disorder and post-traumatic stress disorder (PTSD), there has been growing interest in the rapid mood-enhancing effect of ketamine.

Objectives
To analyze what has been posted about ketamine use for dealing with self-reported depression and/or PTSD on one of the biggest international message boards on the internet.

Methods
Qualitative study with online observation of threaded discussions on Bluelight. In-depth online searches were conducted in 2018. Twenty-nine threads, with a total of 708 units of analysis, were selected and subjected to content analysis, where, via a coding process, the units of analysis were organized into nodes.

Results
Despite having several negative effects (e.g. dizziness, nausea and inability to talk), the examined discourses suggested that the use of ketamine to elevate mood was both efficient and worthwhile. Intranasal use was the most common route of administration mentioned. We traced how the mood enhancement caused by ketamine is perceived: the loss of pleasure disappears, as well as the depressed mood; the markedly diminished interest in activities vanishes and motivation comes back. From all the posts analyzed, only two reported negative outcomes (i.e. no mood-enhancing effect). The most mentioned adverse event was damage to the urinary bladder and the kidneys in cases of misuse.

Conclusion
Although online research of user-generated content has its limitations in terms of reliability and validity, the present study adds relevant information on the use of ketamine for managing depression and PTSD, whether this use is done legally or not.



Annotated version of the final paragraph in the conclusion of the article is quoted below:

Ketamine appears to be a potential tool in managing depressive symptoms. The increasing popularity of ketamine clinics and the FDA approval of esketamine for TRD (treatment resistant depression) say a lot about the current status of off-label ketamine: it seems to work in several situations and people are already benefiting from it (not only people living with depression or PTSD; another popular off-label use of ketamine is for treating chronic pain). Ketamine has the potential to benefit a big group of patients who do not respond to the available therapies. It is considered by the World Health Organization an essential medicine and restricting it has harmed patients, with no reduction in recreational use. More scientific research is needed, naturally, but there is already a substantial amount of data suggesting that ketamine is effective and safe. “If they don’t bring us the treatment, we will make it ourselves”, a T1 member stated (Bluelight quote from thread no. 1). From the black market to the white coat, ketamine as a mood enhancer has been presenting positive results in handling depression and PTSD, giving a novel approach to the pathophysiology and therapy of these conditions.


I think we should be proud to have contributed to an article that advocated greater availability of ketamine as a medicine for depression and PTSD. :)


Note that the full-text article is behind a paywall, but if you have issues accessing and want the pdf, send an email to [email protected]
In Israel we have used it in PTSD within the IDF going on 3-decades now. PTSD is not that common here. only the last decade or so is de-Class. The latest trend is mega-dosaging.. anyway, if it may further PTSD Treatment in the West, all for it. Good luck
 
It's easier to kill yourself off OTC paracetamol than with a dissociative probably.
If your intent is to commit suicide maybe. But you don't get addicted to paracetamol and overuse it destroy internal organs (see ketamine and organ damage sticky thread in the psych forum).


Famous DJ Eric morillo recently died of a ketamine overdose per the medical examiner, a rare thing indeed tho but K use in general is rare so factor that in.. He didn't want to kill himself, the drug is just so addictive you keep doing more and more. This is not a characteristic of paracetamol.

Paracetamol doesn't cause you to have a compete break with reality amd run out into traffic Ala pcp (yes mxe can do this too). I've IVed mxe and lost total touch with reality and all control of my actions psychotically screaming walking into furniture destroying the house.

Another friend was naked running the streets on mxe just like PCP. Was hogtied by the cops. Definitely potential to kill oneself due to the moreishness and addictivness of dissociative either by progressive organ damage though chronic use or just being shot by the cops or being run over by overdosing.
 
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