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Heroin Black pepper before suboxone

N

NeoLid

Bluelighter
Joined
Oct 26, 2014
Messages
90
So I've read buprenorphines metabolite norbuprenorphines is a much more potent and a full agonist, but it can't cross the BBB for the same reason loperamide cant. As many of you have probably heard people eat bunch of black pepper with loperamide and get an opiate high. Im just wondering if this same process could be used to potentiate suboxone.

Edit: Just realized I accidentally picked heroine as the pre-fix wheres I meant to pick opiates if a mod could change that I would appreciate it.
 
Last edited:
Bupe is probably broken down by CYP enzymes that black pepper inhibits so this might stretch out the length of your suboxone. On the other hand, you're also going to make the antagonist last longer because naltrexone is broken down by the same enzymes as well. I imagine the impact of black pepper on something crossing the BBB is negligible and the only big difference you'd notice would be duration of effect and maybe peak effects. That is, you may as well just be taking more sub.
 
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