Benzos benzo insufflation thread!

[NIJJA666]

Aren't we not supposed to use SWIM? The only benzo I know you can't get high off snorting is Ambien. It doesn't work. You have to take it orally.

not a benzo and not a gd z drug zopiclone works far better and lasts a hell of a longer

 

[LearntYoung]

Alprazolam

Alprazolam is a white to off-white crystalline powder, which is soluble in methanol or ethanol; sparingly soluble in acetone; freely soluble in chloroform; slightly soluble in ethyl acetate; freely soluble in dichloromethane but which has no appreciable solubility in water at physiological pH.


Nasal insufflation (often called "snorting") sometimes occurs, but due to the drug's chemical structure and excipients in the ground tablets it is possible that these could act as a buffer, preventing the active ingredient from being absorbed through the mucous membranes. Instead, the powdered tablets and mucous drip down the back of the throat into the stomach, where they are absorbed as they would have been if taken orally. Therefore, insufflation of crushed alprazolam tablets is no more potent than when taken orally. This method of administration can be very unpredictable because it often requires a higher dose to produce an effect and side-effects such as memory loss, loss of motor-function and slurred speech are more likely to become present. Furthermore, nasal insufflation may be significantly less potent than other means of administrations, because the mucous drip enters the stomach at a slower rate than traditional ingestion. Because of fillers, snorting crushed alprazolam tablets causes moderate nasal inflammation. For a list of excipients in alprazolam tablets, see INACTIVE INGREDIENTS. Note: The composition and amount of excipients in generics may be different from those in the brand name product. Panistat, an intranasal formulation of alprazolam is safely and effectively absorbed through the nasal passages and acts more quickly.

Source: https://www.erowid.org/pharms/alprazolam/alprazolam_faq.shtml


Conclusion: No.


Diazepam

Valium (diazepam) is a benzodiazepine derivative. The chemical name of diazepam is 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one. It is a colorless to light yellow crystalline compound, insoluble in water.


After oral administration >90% of diazepam is absorbed and the average time to achieve peak plasma concentrations is 1 – 1.5 hours with a range of 0.25 to 2.5 hours. Absorption is delayed and decreased when administered with a moderate fat meal. In the presence of food mean lag times are approximately 45 minutes as compared with 15 minutes when fasting. There is also an increase in the average time to achieve peak concentrations to about 2.5 hours in the presence of food as compared with 1.25 hours when fasting. This results in an average decrease in Cmax of 20% in addition to a 27% decrease in AUC (range 15% to 50%) when administered with food.

Source: http://www.drugs.com/pro/valium.html


Conclusion: No.


Clonazepam

Experimental solubility in water: 100 mg/L (at 25 °C) MERCK INDEX (1996)
Predicted solubility in water: 0.0106 mg/mL ALOGPS
LogS: -4.5 ALOGPS

Source: http://www.drugbank.ca/drugs/DB01068

Serum concentrations of clonazepam after intranasal, buccal and intravenous administrationwere compared in a cross-over study in seven healthy male volunteers. Eachsubject received a 1.0 mg dose of clonazepam intranasally and buccally and 0.5 mgintravenously. A Cmax of 6.3 ± 1.0 ng ml-' (mean; ± s.d.) was measured 17.5 min(median) (range 15-20 min) after intranasal administration. A second peak (4.6 ± 1.3ng ml-') caused by oral absorption was seen after 1.7 h (range 0.7-3.0 h). Afterbuccal administration a Cmax of 6.0 ± 3.0 ng ml-' was measured after 50 min (range30-90 min) with a second peak of 6.5 ± 2.5 ng ml-' after 3.0 h (range 2.0-4.0 h).Two minutes after i.v. injection of 0.5 mg clonazepam the serum concentration was27 ± 18 ng ml-'. It is concluded that intranasal clonazepam is an alternative to buccaladministration. However, the Cmax of clonazepam after intranasal administration isnot high enough to recommend the intranasal route as an alternative to intravenousinjection.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365135/pdf/brjclinpharm00010-0107.pdf


Conclusion: No.


Lorazepam

Experimental solubility in water: 80 mg/L (at 25 °C) MERCK INDEX (1996)
Predicted solubility in water: 0.0176 mg/mL ALOGPS
LogS: -4.3 ALOGPS

Source: http://www.drugbank.ca/drugs/DB00186


Conclusion: No.


If I remember correctly you can pick from Midazolam, Pyrazolam and Flubromazepam. Anyway: Good luck with the search!