Article on Interactions between common MDMA substitutes affecting absorption

[phase_dancer]

As reports indicate so many tablets are around these days that may contain various mixtures of MDMA, ketamine, methamphetamine and caffeine, this paper offers an interesting insight into how combinations of these drugs may affect absorption and plasma concentration.

Forensic Sci Int. 2007 Jul 4; : 17614227

Interactions between 3,4-methylenedioxymethamphetamine, methamphetamine, ketamine, and caffeine in human intestinal Caco-2 cells and in oral administration to rats by Kenji Kuwayama , Hiroyuki Inoue , Tatsuyuki Kanamori , Kenji Tsujikawa , Hajime Miyaguchi , Yuko Iwata , Seiji Miyauchi , Naoki Kamo , Tohru Kishi

Amphetamine-type stimulants (ATSs) are often abused orally in the form of tablets for recreational purposes. The ATS tablets contain one or more active ingredients such as 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine (MA), ketamine (KA), and caffeine (CF). The aim of this work is to determine whether such components in tablets interact with each other in intestinal absorption. The interactions between MDMA, MA, KA, and CF in the uptake and permeation by human intestinal epithelial Caco-2 cell line were investigated in monolayer cultures. MDMA, MA, and KA mutually inhibited the uptakes by Caco-2 cells. The inhibition of MA uptake by KA was the greatest of all combinations (72.6% inhibition). Similarly, MDMA, MA, and KA mutually inhibited the permeation from the apical to the basolateral side through Caco-2 cells. Although CF did not affect the uptakes of MDMA, MA, and KA, CF enhanced the permeation of MDMA in comparison to MDMA alone. In addition, the interaction of MA with KA and that of MDMA with CF in intestinal absorption were investigated by oral administration to rats. The area under the plasma concentration-time curve of MA significantly decreased by co-administration with KA in comparison to MA alone, while that of MDMA significantly increased by co-administration with CF in comparison to MDMA alone. The results in rats were similar to those in Caco-2 cells. These findings suggest that the intestinal absorption of similar compounds with amine moieties such as MDMA, MA, and KA are mediated by a common transport system, and that CF affects the absorption of MDMA in a different way from the transport system. In human, intakes of ATS tablets mixed with such components might result in similar interactions in intestinal absorption to those in Caco-2 cells and rats.

From here

 

[ayjay]

Interesting - particularly the stuff about caffeine increasing bioavailability ("area under the curve" right?)!

It's my understanding that caffeine is also often used as a cut in heroin intended for smoking, because it increases the effectiveness of smoking.. not sure of any research to back that though..

 

[Splatt]

Its been long known that meth and caffeine make a drug come on quicker because they speed up absorbtion. Even (pseudo)ephedrine does this.

Low doses of K are also a trick, but not a metabolism thing, to make it seem like a pill is coming on faster therefore making the user think its a strong pill.