anti-histamine + mdma negative? URGENT

[turkish]

ive just had 100 mgs of promethazine (phenergan) but i got this massive craving to pop an e before i go out.. does anyone know of a bad mix with anti-histamines and mdma if so please reply i gotta know before i leave in an hour or so..

 

[zaki]

i dont know of any adverse effects that combo would cause, except perhaps you may find yourself in a very dreamy MD'd state as phenergan is known for having a very drowsy effect. From personal experience with phenergan it causes me to have very vivid dreams that i can be physically involved in, so i cant imagine what sort of effect it would have on me with MDMA in my system, i cant see any negative effects, but i dont know that i would want to be out of the house as i would imagine the combo could potentially have a disassociative effect.

 

[turkish]

thanks for the reply i just drew my 2 lines now haven a blue daredevil.. ill keep yous posted

 

[sweetasabikkie]

Would it be similar to having k on a bikkie?

 

[kryalkastleE]

ive had them after a pill, just made me go to sleep?

 

[phase_dancer]

NOT advisable!!

MDMA 's principle metabolic pathway uses the same cytochrome; P450 CYP2D6

CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes.

To determine which cytochrome P450 form is involved in the promethazine [10-(2-dimethylaminopropyl) phenothiazine] metabolism, in vitro analysis using human liver microsomes were performed. Promethazine was mainly biotransformed to ring-hydroxylated, S-oxidized and N-demethylated metabolites. The promethazine hydroxylase in human liver microsomes was inhibited by SKF-525A, propranolol, sparteine, quinidine and anti-CYP2D6 serum suggesting involvement of a P450 related to CYP2D6.

Lineweaver-Burk plots for the hydroxylation, S-oxidation and N-demethylation indicated that the hydroxylation occurred with a low K(m) value in human liver microsomes. Microsomes from genetically-engineered human B-lymphoblastoid cells expressing CYP2D6 hydroxylated promethazine most efficiently as compared to other P450 forms, indicating that it was the principal P450 responsible for the metabolism of promethazine in human liver microsomes. The inhibition of CYP2D6-catalysed bufuralol 1'-hydroxylase by various histamine H3 antagonists including promethazine suggested that promethazine and some other histamine H1 antagonists could be inhibitors of this P450 in human liver microsomes.

 

[KemicalBurn]

^this thread was posted last night...what would the poster be experiencing (ie: the effect of this)?

He said he'll come back and keep us posted.