^ Huh? We've already established long ago that alcohol increases buprenorphines bioavailibility.. Did you read the first page of this thread? Do you have any evidence to prove the first page wrong?
(From Lorne)
"I don't know why this hasn't gotten through to people; YOU DO NOT NEED TO USE ETHANOL TO INCREASE BUPE BA%.
Ethanol was used in the original study, for whatever reason,(probably solubility?) but subsequent studies using plain H2O have gotten the same results, increasing BA by 1.5-1.75x, regardless of the presence of alcohol.
But never mind that. The very existence of Zubsolv(roughly 1.5x as potent as bupe itself) proves that you don't need alcohol.
And no, it's no magic ingredient in Zubsolv; it's simply that they dissolve MUCH more rapidly than suboxone(and they're smaller).
Look it up yourself. Nothing special, the menthol is merely a flavoring. And they certainly do not contain ethanol.
It was suggested from the beginning by researchers that the increased BA from the solution was because it absorbed rapidly, with the small amount of ethanol present being coincidental. Other thought it was the ethanol, sure, but ultimately, the former group was proven right.
I have posted various proof of this earlier in the thread, check yourselves. But again, it is all entirely irrelevant, with the existence of Zubsolv, who's own site says the increased BA is because of more rapid absorption.
I respect sixpart7, and his intentions were good, but it is now outdated data. Sticking freaking 40% Ethanol under your tongue is painful and unnecessary.
For an increase in potency(and a faster onset) simply dissolve your dose in 0.5-1ml of water,(either soon or shot glass, and then administer it directly under the tongue. Hold for at least 5 minutes(or as long as you want) and voila, your bupe dose is now significantly more potent. It's that simple.
BTW, I doubt even the original study used 40%abv, that's harsh.
Anyway, if anyone can find anything to dispute that, or more importantly, any unknown reason why alcohol free Zubsolve is more potent, feel free. But please, don't just stand on tradition and say "NO!" in the face of clear and logical evidence.
A final word: if you want to continue using an ethanolic solution, fine by me, it's your tongue, and your body. At least think on it, and lower the abv. Again, 40% seems like it woul be difficult to hold in the first place.
Oh, and when it comes to liquid solutions, studies state that, beyond a few minutes, the amount of time the solution is held doesn't seem to matter, though I still would hold mine as long as possible..."
