Activity differences between phenethylamine and tryptamine psychedelics

[HOOH]

One difference in the tryptamines and psychedelic phenethylamines that I see often overlooked, is their difference in terms of "spiritual" potential.

It seems that tryptamines almost always generate feelings of profundity and insight, whereas the phenethylamines, be it mescaline, DOM, whatever, tend to have less of these, despite often being just as powerful 5-HT2A receptor agonists.

Does anybody have any any info on why phenethylamines (especially NBOMes) lack the "enlightenment" properties that classical tryptamine-derived psychedelics have, and what's the pharmacological reason for it? Is there some special receptor that only indolamines activate that I'm not aware of?

 

[izo]

might have something to do with functional selectivity.

 

[plumbus-nine]

Actually I never dabbled too deep with psychedelics (yet) due to lacking set & prone to anxiety but from what I think to know, the phens will have some stimulatory/amph-like activity and thus give an effect like a tryp + some speed, which could abolish the deepness of experience ... e.g. mescaline is said to be stimulating - I know that LSD is too, 1cP-LSD is one of the psychs I've done (in lower dose) but it certainly didn't have psychostimulant signature and sleep wasn't difficult afterwards.

But yeah I'm curious about why DMT is able to transform you into a complete different dimension whilst other tryps aren't?

 

[HOOH]

But yeah I'm curious about why DMT is able to transform you into a complete different dimension whilst other tryps aren't?

They are actually, the primarily difference is the ROA, if you were to IV psilocin, it would be actually more intense (per mg) than DMT. Now 5-MeO-DMT's ability to abolish all dimensions, that's the real mystery.