What should one expect, pharmacologically, behaviorally and subjectively from a combination of an acetylcholinesterase inhibitor like Galantamine or Huperzine-A and a serotonergic psychedelic like LSD or psilocybin mushrooms? Are there possible harmful effects? Synergies?
Classical (serotonergic) psychedelics act on the 5HT2A receptor and are well known to produce enhancement of creativity, imagination, intuition and a sharpening & distortion of perception as well as an overall dream like state while retaining full consciousness.
On the other side reversible acetylcholinesterase inhibitors, like the ones just cited, are more commonly used as nootropics to sharpen memory, attention and general cognitive abilities in patients with dementia-like diseases and as mind boosters in the general population.
The other not as well known properties of these substances are increase in REM sleep duration, sleep quality improvement, enhanced vividness and recall of dreams. For these reasons many people uses them for purposes of lucid dream & OBE induction and to enhance dreams recall.
I wander what the effects of such a combination would be, and i believe we could expect greater ability to recall experience and insights after the session, greater lucidity and an enhanced working memory during the experience, useful for giving a purpose and an intentional direction to the experience i.e. guiding the psychedelic state to obtain more precise therapeutic effects.
However sadly reports of such combos are very rare to non-existant (me never tried neither the combo nor the AChEIs by themselves) and having more information on this would be of incredible value so, in the absence of reports we could try to elucidate the matter through pharmacologic inference.
What are the interactions of the brains Cholinergic and Seroronergic systems? (How) do they influence each other?
In specific, what are the interactions of 5HT2A rec with the cholinergic system?
The 5HT2A receptor is a receptor subject to functional selectivity, it means that different agonists elicit a different Second Messenger in response to receptor activation. For example Serotonin, when bound to the receptor, gives Inositol Triphosphate as its second messenger, on the contrary LSD and classical psychedelics have Arachidonic Acid as second messenger.
How does the arachidonic acid signaling couples with cholinergic transmission?
I would expect strong synergy between these two kinds of substances but i would like to open a discussion, i want to hear some of you well informed geeks but any input is really appreciated as this subject is pretty obscure and unknown!!!
Bom Shiva!!!
Classical (serotonergic) psychedelics act on the 5HT2A receptor and are well known to produce enhancement of creativity, imagination, intuition and a sharpening & distortion of perception as well as an overall dream like state while retaining full consciousness.
On the other side reversible acetylcholinesterase inhibitors, like the ones just cited, are more commonly used as nootropics to sharpen memory, attention and general cognitive abilities in patients with dementia-like diseases and as mind boosters in the general population.
The other not as well known properties of these substances are increase in REM sleep duration, sleep quality improvement, enhanced vividness and recall of dreams. For these reasons many people uses them for purposes of lucid dream & OBE induction and to enhance dreams recall.
I wander what the effects of such a combination would be, and i believe we could expect greater ability to recall experience and insights after the session, greater lucidity and an enhanced working memory during the experience, useful for giving a purpose and an intentional direction to the experience i.e. guiding the psychedelic state to obtain more precise therapeutic effects.
However sadly reports of such combos are very rare to non-existant (me never tried neither the combo nor the AChEIs by themselves) and having more information on this would be of incredible value so, in the absence of reports we could try to elucidate the matter through pharmacologic inference.
What are the interactions of the brains Cholinergic and Seroronergic systems? (How) do they influence each other?
In specific, what are the interactions of 5HT2A rec with the cholinergic system?
The 5HT2A receptor is a receptor subject to functional selectivity, it means that different agonists elicit a different Second Messenger in response to receptor activation. For example Serotonin, when bound to the receptor, gives Inositol Triphosphate as its second messenger, on the contrary LSD and classical psychedelics have Arachidonic Acid as second messenger.
How does the arachidonic acid signaling couples with cholinergic transmission?
I would expect strong synergy between these two kinds of substances but i would like to open a discussion, i want to hear some of you well informed geeks but any input is really appreciated as this subject is pretty obscure and unknown!!!
Bom Shiva!!!
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
