Humongous affinity for opioid mu + sigma + DAT + NMDAr = a dependency-producing stimulant psychedelic that produces stimulant dissociative f/x predisposed towards psychosis at low to medium doses, breathing depression and total anesthesia at high doses, death at much lower doses than e.g. ketamine/PCP alone, and would be expected to be potent and active at ~0.5mg in a naive user.
The 3-MeO PCx analogs are already known for producing psychosis and are v. potent. Don't need to go make them even more potent and add an opioid component. As Soli pointed out, fellow board member F&B had an incident with 3-MeO-PCE that resulted in psychiatric hospitalization.
Seeing as the guy who wrote that report on ACH analogs was highly tolerant of morphine & opioids, and 3mg of 3-ho-pcp knocked him flat out... do you want to mess with a drug where accidentally handling/inhaling dust causes death and psychosis? Fentanyl style?
This is basically a less safe version of MK-801. Not my cup of tea. Don't reccomend any of the 3-HOs to anyone without a good containment glovebox and a good 10/100microgram scale. And an iron will.
If you can't figure out this compounds solubility in water then you shouldn't even touch the shit. This is a Research Chemical in true form and a layman will get himself killed treating it like Meow Meow or MXE.