2 minute formed sticky HPBCD DMT liquid very bioavailable sublingually under tongue & outperforms DMT salts orally by many factors in personal trials

[tregar]

Update 2.17.2023:

Sublingual Ayahuasca, my psychedelic of choice: https://www.shroomery.org/forums/showflat.php/Number/28189371

hxxps://www.shroomery.org/forums/showflat.php/Number/28189371 (change hxxp to http to link)

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7.24.2022 update:

1) How to make THH or tetrahydroharmine with pics, post #13:
https://mycotopia.net/topic/111610-hpbcd-dmt-sublingually-active-under-tongue/
THH can be made by converting harmaline from rue seeds in 1.5 hour using vinegar, zinc dust, magnetic stirrer and 10% janitorial ammonium hydroxide from the hardware store or on-line.

2) One shot HPBCD DMT Ayahuasca, masks taste and increases absorption many factors with pics, post #42:
https://mycotopia.net/topic/111610-hpbcd-dmt-sublingually-active-under-tongue/page-3

3) Journal: 50 Sublingual HPBCD DMT Ayahuasca journeys over a years time with pics, post #19:
https://mycotopia.net/topic/111790-...bcd-dmt-ayahuasca-journeys-over-a-years-time/

4) LSH extract tek: 500 Heavenly blue morning glory extract in 1oz everclear + 1 oz wine, imagine your best 2 hit LSD experience x 2

Lysergamides - Zero nausea morning glory LSH tincture based on 2022 LSH study, natural LSD

Compilation of panaeolus cyanescens experiences & combo with THH or tetrahydroharmine, like organic psilocin LSD: https://bluelight.org/xf/threads/compilation-of-panaeolus-cyanescens-experiences-combo-with-thh-or-tetrahydroharmine-like-organic-psilocin-lsd.927995/...

bluelight.org

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Update:

THH or Tetrahydroharmine + 1-acetaldehyde LSD (similar to ALD-52) combo, like high dose mescaline with pics:

Lysergamides - THH or Tetrahydroharmine + 1-acetaldehyde LSD (similar to ALD-52) combo, like high dose mescaline

Tetrahydroharmine + 1-acetaldehyde LSD (similar to ALD-52) combo, like high dose mescaline. I've moved on from the 300mg oral THH + sublingual HPBCD DMT, onto a 100% oral alternative, no re-dosing necessary every 1.5 hour like with the HPBCD DMT: I'm not going to totally abandon the sublingual...

www.bluelight.org

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Update:

JOURNEY #46, 10-4-2021 monday night, post #47, been 10 days since taking anything.

MOST INTENSE +5 Shulgin level journey in 5 months with pics.

300mg pure THH taken in a capsule 45 minutes before, then 30mg harmine fb held under tongue at exact same time as 110mg HPBCD DMT held under tongue, re-dosing two more times with same every 1.5 hour, super strength 4.5 hour experience, like 700mg mescaline, +5 Shulgin level strength for 4.5 hours.

Page 3, post #47 with pics: (16) 2 minute formed sticky HPBCD DMT liquid very bioavailable sublingually under tongue & outperforms DMT salts orally by many factors in personal trials | Page 3 | Bluelight.org
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Continuation update with pics here at BL:

Tryptamines - HPBCD DMT part II

I use the sublingual HPBCD DMT weekly with zero nausea or dizziness used sublingually. Big difference compared to oral Ayahuasca which always make me feel nauseated, uncomfortable, dizzy like and with anxiety, with sublingual there is none of that. Take a look at L-dreamer's many experiences...

www.bluelight.org

HPBCD (hydroxy propyl beta cyclodextrin) is a new medical pharmacology technology that allows freebase nonpolar drugs like DMT to be trapped by the cyclodextrin inner cavity which is composed of an inner "non-polar trap", and "outer polar cavity or cone" which allows the normally water insoluble DMT to be made 100% water soluble.

HPBCD is composed from a sugar molecule, it has been used to make scores of other non-water soluble drugs 100% water soluble and reach peak activity as measurements of the drug in the bloodstream indicated that all of the freebase drug was absorbed effectively.

Been running many experiments over several weeks, method and results posted here with pics:

Journal: 50 Sublingual | <span style="frontcolor:pink !Important ;">High Pobability of Braindamage by Creepy non tested Drugs (forced by scammer 69ron)</span> | DMT Ayahuasca journeys over a years time - Pharmahuasca - Welcome to the DMT-Nexus

www.dmt-nexus.me

Tomorrow's experiment:

Loveall came up with a GREAT IDEA which I would never of thought of on my own. He suggested taking a sublingual harmala + DMT all in HPBCD complexed form to simulate Ayahuasca. I find this a great idea as I would like to avoid the slight dizziness that harmine at 200mg gives me for a couple hours. So this is what I will do tomorrow, and show 4 pics.

That's the great thing about Ayahuasca, you can take her at least once a week, and there is no tolerance, it's been a week since last experiment, so I will give it a go.

Dr. Narang saids "under the tongue" pharmaceuticals are at least 3 to 10 times stronger than oral pharmaceuticals, so since 200mg of harmine is potent orally, I will use 1/6th the amount sublingually or 35mg of harmine.

"Sublingual mucosa as a route for systemic drug delivery" by Narang & Sharma 2010:

https://innovareacademics.in/journal/ijpps/Vol3Suppl2/1092.pdf

The 75mg combined 35mg harmine + 40mg DMT should absorb just fine: even 100mg doses of viagra can be administered under the tongue, the scientist noting that much less of the drug was required, and that it began working in only one half the normal time of an oral dose:

"The start of pharmacological activity after sublingual administration of sildenafil citrate in 30 patients affected by erectile dysfunction." by Siati & Franzolin 2003: https://pubmed.ncbi.nlm.nih.gov/12741340/
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Also, 70 DMT complexed to 490mg HPBCD in 0.5ml very hot water formed a clear solution after 2 minutes of mashing together, which when I used orally with 200mg harmine + 250mg THH all mixed together in 2oz hot water...was indeed many factors more potent and "all encompassing" (+5 Shulgin scale ) just like 30g hawaiian psychotria leaf brew as compared to free base or DMT salts used orally in a brew (all were mild +3 experiences ), similar to many pharmacology studies, for example:

HPBCD improves oral absorption profile for Ofloxacin, a second generation fluroquinolones from 54 to a whopping 89 percent. (y)
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I will as usual take 250mg tetrahydroharmine orally 1 hour before, it never gives me any nausea or dizziness at this dosage or less, 150mg to 250mg is recommended, as it's the 2nd highest ingredient in Caapi based true Ayahuasca.

1st pic will show = 35mg harmine freebase + 40mg DMT all next to the HPBCD powder.

210mg HPBCD to complex the harmine + 280 HPBCD to complex the DMT = 490mg HPBCD total.

So the pic will show a pile of harmine, a pile of DMT, and a pile of 490mg HPBCD powder.

* Molecular weight of harmine = 212, molecular weight of HPBCD = 1300. Thus a 1:1 molar ratio = 1:6 host drug to HPBCD mg weight ratio.

* Molecular weight of DMT = 188, molecular weight of HPBCD = 1300. Thus a 1:1 molar ratio = 1:7 host drug to HPBCD mg weight ratio.

490mg HPBCD may look like a lot when laid out on spoon, but once you add several drops of very hot near boiling water from a pipette taken up from a nearby coffee mug, the HPBCD shrinks into a small sticky clear liquid mass as it is derived from a sugar molecule, perfect for "under the tongue" use. 1000mg of HPBCD dissolves into 1ml (20 drops) water at room temp, the solubility even goes way beyond this when using very hot water. On a glass dropper: 0.250ml = 5 drops, 0.500ml = 10 drops.
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2nd pic will show the 35mg harmine + 40mg dmt + 490mg HPBCD powders all on a spoon with the very hot near boiling drops of water added that I will be using.

3rd pic will show the (hopefully) transparent clear homogenous solution on the spoon after kneading and mashing it all together for 2 minutes or so.

4rth pic will as usual show a woman with tongue exposed (a la ava69 believes that women, like Mother Earth, are caretakers of this planet, a feminist ethic that binds us to mother earth), showing how the drops are then put under tongue and held for 15 minutes, strong effects commencing 5 minutes after the 15 minute sublingual period.

If this [35mg harmine freebase complexed to 210mg HPBCD] + [40mg DMT complexed to 280 HPBCD], total = 75mg alkaloids complexed to 490mg HPBCD works tomorrow, this sublingual "under the tongue" administration of it all could very well be my favorite way of using this, as I would like to mimimize the normal way I do this of using 200mg oral harmine which always gives me slight dizziness and heaviness for couple hours.
---------------------------------------------
From 2015 Nexus thread "My sublingual Harmala freebase experience":
"Steppa:
When I use harmalas sublingual I use them in a range between 25mg and 40mg and get good effects.

Goneandback:
I never exceed 35mg sublingual and have strong effects from just that. You can activate dmt sublingualy if you take the harmalas that way as well, but sublingual harmalas will not inhibit the enzymes that are present in your gut which are responsible for the break down of dmt. If you take the harmalas sublingually, you will need to take the dmt sublingually as well. I am not sure on the dosage for this though.

jamie:
30mg sublingual sounds about right for sufficient mao inhibition..and for me at least some visionary or entheogenic effects. 50mg sublingual can be a large dose. It is very active sublingual. Oral doses are naturally much higher at 200mg."
--------------------------------------------
Last week, using 10 drops of very hot water to complex 70mg of DMT to 490mg HPBCD for oral use, it was an excess of water...so I'm certain I will be able to use between 5 and 7 very hot water drops to complex the above for tomorrow for sublingual use.

Of course, I always take 250mg of tetrahydroharmine (THH) orally around 1 hour before the sublingual harmine + DMT for a "true Ayahuasca journey experience."

Just like Professor8 said back in 2010, she (THH) has the ability to raise your vibration or whole-body frequency (this is really felt strongly) in a most powerful way. She brings a diamond-like crystalline prismy texture & super clear watery dimension to Ayahuasca, like looking down through 10 meters of shimmering Caribbean Sea on clear blue day. She brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order.

 

[tregar]

Thanks plumbus_nine.

the formed complex liquid will remain stable indefinitely in a tincture, it can be frozen. Don't leave in fridge for more than a few days or bacteria could grow.

I'm taking 250mg THH orally one hour beforehand, then will take the 35mg harmine + 40mg dmt (75mg total alkaloids) all complexed to 490mg HPBCD powder (forms a 0.500ml or 10 drop solution after 2 minutes of kneading or mashing the mix on a spoon using very hot water drops using end of spoon) held under tongue for 15 minutes, and report results tonight, along with pics of the process.

This being done to simulate "true Ayahuasca" but hopefully without experiencing "the slight dizziness and heaviness" I experience from using 200mg oral harmine. THH causes me no nausea or dizziness whatsoever at 250mg, so I love to use it in combination all the time, imho 250mg THH is very similar to 250mg of mescaline, very beautiful compound. It combines extremely well with DMT.

Have over several weeks experienced 30mg, 35mg and 50mg sublingually and 70mg orally, trip reports above in this thread. The HPBCD DMT absorbs very well under tongue, but I am trying the above to see if the harmine will MAX OUT the activation of the sublingual DMT, hopefully resulting in maximum powerful Ayahuasca, identical to oral potent Hawaiian psychotria effects, which I have over 70 experiences. The harmine also has nice effects (like being in a relaxing hot tub) on it's own which I wish to include.

This will be my last post, as I need to head back to the gym & water park over the summer.

I will leave it up to the rest of you to experiment should you wish to. I love the HPBCD DMT so much, that I will continue to use it the rest of my life. I'm a very visual person, and love good music, that's why I like to show lots of pics. Ayahuasca is a great way to stay Psychedelic for the rest of your life.

Stay true to yourself. Love, peace and music
http://friskyradio.com

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Ready for tonight:

1) 35mg harmine + 40mg DMT + 490mg HPBCD laid out

2) 75mg alkaloids + 490mg HPBCD put in spoon

3) 10 drops (0.500ml) near boiling water added from a nearby coffee cup, used the end of a spoon to knead, mash & stir it all together for 2 minutes, light brownish liquid formed, stored in fridge till ready. Alternately, a mortar & pestal can be used to knead & crush/stir the alkaloids into the HPBCD.

4) Tonight: take 250mg tetrahydroharmine 1 hour before, then place 0.5ml solution under tongue, hold for 15 minutes, 5 minutes later harmine + fully activated 40mg DMT should be felt strongly, for 60 to 90 minutes of strong effects. Re-dose again later if want to.

 

[tregar]

Results:

1) The HPBCD harmine + DMT sucked really bad, I think the harmine interfered not only with the complexing of the DMT but also the absorption of the DMT under tongue, will never repeat again, effects were very mild.

2) So then, 1 hour later I complexed 60mg of DMT to 420mg of HPBCD, shown in pics, held under tongue for 15 minutes, and it began to come on in only 10 minutes, beautiful strong effects! Now that's more like it, long duration about 60 to 90 minutes total. As usual, took 250mg THH 1 hour before. Bad ass!

Experienced PHENOMENAL strength, active for 90 minutes, profound open eyed beauty, maxed out dilated pupils, heavy CEV imagery, music incredible, very euphoric.

3) So my favorites are:

* For oral use: 70mg DMT complexed to 490mg HPBCD using 10 very hot water drops, mashed all together on spoon for 2 minutes, then add this to 2oz of hot water containing 200mg harmine + 250mg tetrahydroharmine + 150mg pure ascorbic acid (vit c) to help dissolve freebase harmalas = 10 out of 10, this gives an experience identical to using 30 grams of potent Hawaiian psychotria, I've had over 70 Ayahuasca journeys using Caapi + hawaiian psychotria, and this was no different! zero nausea and went down in one gulp--taste was pretty much non-existent. All of my dozen 70 to 120mg freebase or DMT salt used orally with Caapi were all only +3 on shulgin scale, all very mild. This on the other hand was a +5 on Shulgin scale, just as strong as the leaf and all encompassing like the leaf. See trip report on post #25.

I'm glad to discover this, as for years all the dried Hawaiian psychotria has been extinct, I think it has all been diverted to the numerous Ayahuasca centers in South America.

* For sublingual use: 60mg DMT complexed to 420mg HPBCD using 10 very hot water drops, mashed all together on spoon for 2 minutes, then pour this under tongue and hold for 15 minutes = 9 out of 10, very awesome strength and zero nausea, it stings a little, but the results are worth it, at the end of the 15 minutes, I spit out all the saliva that's collected in mouth into a cup instead of swallowing...nice long 90 minutes duration

I just took a strong cactus tea in combination with the still working effects of the 60mg sublingual DMT to enjoy the rest of the evening off.

Pic here: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861&p=2

 

[MBaggott]

One note of caution about cyclodextrins: several are ototoxic and can cause hearing loss if they get absorbed, see eg https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.306 (If they didn't have this toxicity, they might be a great way to reduce cholesterol, which is why I was researching them.)

 

[tregar]

Good point MBaggott. Cyclodextrin has been linked to some studies in mice at very high doses of 8000 mg/kg s.c. We are not using doses anywhere near that here. I have used HPBCD complexed to pro-hormones for years when pro-hormones were legal and never had any side effects at low level like we are using. Patrick Arnold is the chemist who created hydroxypropyl-beta-cyclodextrin complexed diols such as Cyclo-Diol(TM) and Cyclo-Nordiol(TM) and sold them for nearly 10 years thru his company ERGOPHARM, never any complaints of hearing loss. See part 5 of my paper on his story and bloodwork results.

 

[specialrelativity]

But what is N,N-DMT?

 

[tregar]

Many others have joined in the conversation: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861&p=2

 

[MBaggott]

Good point MBaggott, "hydroxy propyl beta cyclodextrins" are completely safe.

The way I would put it is HPβCDs are safe if not injected. This is because they are broken down in the gut and not absorbed. If injected, they would potentially cause dose-dependent deafness, as is seen in animals and in the limited clinical trials with parenteral administration to people.

"Despite the potential health benefits, use of HPβCD has been linked to significant hearing loss in several species, including humans. Evidence in mice supports a rapid onset of hearing loss that is dose-dependent. Ototoxicity can occur following central or peripheral drug delivery, with either route resulting in the preferential loss of cochlear outer hair cells (OHCs) within hours of dosing. Inner hair cells and spiral ganglion cells are spared at doses that cause ~85% OHC loss; additionally, no other major organ systems appear adversely affected. Evidence from a first-to-human phase 1 clinical trial mirrors animal studies to a large extent, indicating rapid onset and involvement of OHCs. All patients in the trial experienced some permanent hearing loss, although a temporary loss of function can be observed acutely following drug delivery." From
https://www.frontiersin.org/articles/10.3389/fncel.2017.00355/full
So my point is don't inject this stuff. Not that you were. But someone might eventually get the idea.

 

[Skorpio]

The way I would put it is HPβCDs are safe if not injected. This is because they are broken down in the gut and not absorbed. If injected, they would potentially cause dose-dependent deafness, as is seen in animals and in the limited clinical trials with parenteral administration to people.

"Despite the potential health benefits, use of HPβCD has been linked to significant hearing loss in several species, including humans. Evidence in mice supports a rapid onset of hearing loss that is dose-dependent. Ototoxicity can occur following central or peripheral drug delivery, with either route resulting in the preferential loss of cochlear outer hair cells (OHCs) within hours of dosing. Inner hair cells and spiral ganglion cells are spared at doses that cause ~85% OHC loss; additionally, no other major organ systems appear adversely affected. Evidence from a first-to-human phase 1 clinical trial mirrors animal studies to a large extent, indicating rapid onset and involvement of OHCs. All patients in the trial experienced some permanent hearing loss, although a temporary loss of function can be observed acutely following drug delivery." From
https://www.frontiersin.org/articles/10.3389/fncel.2017.00355/full
So my point is don't inject this stuff. Not that you were. But someone might eventually get the idea.

Do you think sublingual use would be problematic then? It bypasses the gut.

 

[Nagelfar]

But what is N,N-DMT?

Wikipedia — DMT

↑calling 'DMT' = “N,N-DMT” is like calling methamphetamine = "N-methyl-amphetamine". A pedantic systematic naming consideration, usu. dropped as uninformative and unimportant to the chemical in question when referring to it as the psycho-active drug.

If that was indeed the gist of your inquiry. Commonly referred to as the chemical the brain releases near death and related in it's mode of action to the psilocybin type exogenous drugs.

 

[tregar]

Full Journey trip report:

Keep in mind using DMT salts sublingually does not work, and the sting is terrible. The HPBCD complexed DMT works extremely well, the outer water soluble sugary tasting HPBCD keeps the freebase DMT trapped inside it's non-polar cone, so as the complex sits under the tongue for 15 minutes...

...you only feel a mild sting for around 10 minutes as the HPBCD releases the DMT directly into the bloodstream from the mucosa membrane under the tongue (only 100 microns thick) as the freebase, only as the freebase will it reach from the bloodstream to the brain with maximum effects. I don't have all the answers, I only know it works extremely well. The tongue is completely fine after, and it's as if nothing happened the next day, 100% no scarring or burning, totally normal.

Be sure to press down with tongue the whole time to trap the sticky complex in the sublingual mucosa.

Give this a try...follow 2 step instructions, 60mg DMT complexed to 420mg HPBCD with 2 minutes mashing on a spoon with 10 drops very hot water and poured under tongue, use your finger to rub any liquid from the spoon under your tongue as well, in case any is left...and hold for 15 minutes, begins to work in only 10 minutes...at the end of the 15 minutes, I spit out any saliva that's collected in mouth into a cup instead of swallowing, for me this has been less than 1/4oz or around less than 15ml saliva.

...and is VERY STRONG...I experienced 90 minutes of very strong effects, pupil dilation maxed out, heavy CEV imagery, open eyed beauty profound, music sounds incredible...feels identical to if I had taken 60mg DMT complexed to HPBCD orally with 200mg harmine with 300mg THH, of course I always take 300mg THH orally any time I do this using the sublingual DMT.

I recommend not using more than 250mg of THH if it is your first time. 250mg of THH causes zero dizziness and ZERO nausea, but 300mg will cause a tiny bit of dizziness for a short time if you are not used to it. I am used to it, so I get no dizziness at 300mg.

The effects were so INCREDIBLE, I RE-DOSED 60mg of DMT complexed to 420mg HPBCD x two more times the same night, every 2 hours...it was the bomb...I was in 7th heaven.

...never before have I had such insane visuals all night long...all the way till 5am in the morning I was seeing closed eye visions of slow and high speed movies...I saw brightly colored serpents, dungeons I traveled thru, many Mesoamerican pyramids, women of incredible beauty, Japanese landscapes, dancing geometrics, many different animals on a rotating globe, walking on the planet-like globe as it spun, hundreds of visions like slow and high-speed movies over the course of many hours.

I saw the interiors of many magnificent homes, exposed like a camera flash went off, then off to the next home interior, bizarre alien looking creatures, I saw ancient ruins but they were seen as they were before they fell apart. All sorts of architectural wonders appeared that I could not make out exactly what time period they were from.

All the visions were enchanting & manifested incredible beauty. The multi-colored beautiful serpents kept appearing several times in different forms, as if they have some prominence to do with it all, two of them had shining skin covered in gold scales and intertwined like DNA, reminds me of the Aztec quetzalcoatl myth, the "serpent of precious feathers."

...all of these visions were brightly colored due to the DMT and THH combo all night long..it was one of the most powerful psychedelic experiences of my life...and I've taken Ayahuasca x 70 times, cactus 200 times, etc...I have never had over 5 hours of non-stop CEV visions anything close to what I saw the other night...I was blown away, and will be thinking about this for a very long time...this sublingual DMT along with 300mg THH taken orally 1 hour before is my absolute favorite...there is no nausea...I wore headphones and listened to music the whole time, as the music sounded just like if I had taken a very strong cactus tea...out of this world good...I had non-stop closed eye visions all night long, insane visions...totally blown away.

I love the "oral 250 to 300mg THH + sublingual 420mg HPBCD complexed to 60mg DMT administration" as there is a complete lack of "queasiness feeling during the journey", perhaps because there is no harmine/DMT going thru the stomach & intestines...I don't know the answer for sure, but I like it.

Remember, I took 300mg of THH once early on, then every 2 hours I took 60mg of DMT complexed to 420 of HPBCD sticky liquid under my tongue for 15 minutes held...so I took it x 3 times...one of the most visionary entheogenic experiences of my life.

 

[tregar]

Reply to above: Cyclodextrin has been linked to some studies in mice w/hearing loss at very high doses of 8000 mg/kg s.c. We are not using doses anywhere near that here. I have used HPBCD complexed to pro-hormones for years when pro-hormones were legal and never had any side effects at low level like we are using. Patrick Arnold is the chemist who created hydroxypropyl-beta-cyclodextrin complexed diols such as Cyclo-Diol(TM) and Cyclo-Nordiol(TM) and sold them for nearly 10 years thru his company ERGOPHARM, never any complaints of hearing loss. See part 5 of my paper on his story and bloodwork results.
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Keep in mind tetrahydroharmine is not an maoi, it is an SRI (serotonin reuptake inhibitor). It is the 2nd highest ingredient in Caapi, it has many similarities to mescaline, when combined with DMT, the effects are like "true Ayahuasca".

Shroombee said:

Results of THH plus sublingual HPBCD+DMT trial: It works! (y)

Just a few tips before I depart for the summer to the weight room and waterpark:

1. Take 250 to 300mg of THH or tetrahydroharmine around 45 minutes to 1 hour before, as the combo of THH + DMT simulates true Ayahuasca. THH is not an maoi, it is an SRI or serotonin reuptake inhibitor. Mescaline, ibogaine, LSD, shrooms all inhibit serotonin as well, this serotonin blocking action results in expanded consciousness in combo with the DMT as borders and walls are broken down in the mind as a result. I would not omit the tetrahydroharmine as it is the 2nd highest ingredient in Caapi based true Ayahuasca, very important. It would be like a waterpark without the women and bikini's.

I have seen the receptorome data for THH, it is very similar to mescaline, as THH not only blocks serotonin like mescaline, but agonizes all 3 adrenal receptors just like mescaline (A2A-A2C), these receptors are implicated in not only visionary but feelings associated with aesthetics and beauty.

Using this oral THH + sublingual DMT results in ZERO nausea, ZERO dizziness, ZERO feelings of queasiness as there is no oral harmine/DMT going thru the stomach & intestines.

Just like Professor8 said back in 2010, she, the feminine "THH has the ability to raise your vibration or whole-body frequency (this is really felt strongly) in a most powerful way. She brings a diamond-like crystalline prismy texture & super clear watery dimension to Ayahuasca, like looking down through 10 meters of shimmering Caribbean Sea on clear blue day. She brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order."

2. Sublingual DMT salts do not work, and the sting is terrible. Using this method, the sting is mild to a little moderate, the outer water soluble sugary tasting HPBCD helps with this as it traps the non-polar dmt freebase inside it's tornado cone, as it releases the freebase directly into the bloodstream from the sublingual mucosa, only this way do you get max effects, as the freebase travels from the bloodstream directly to the brain.

3. I found that using the bottom of my tongue to "lick any leftover liquid sticky complex" off the spoon will grab any rest of it once you have poured it off from spoon to under the tongue. I get it all this way. I simply press the spoon against the bottom tip of my tongue to grab any leftover from the spoon.

4. The liquid sticky like complex should have all dissolved, there is none leftover when I do this after 15 minutes, be sure to press down with bottom of tongue the whole time to trap the sticky liquid complex in the sublingual mucosa under the tongue.

5. Don't swish your mouth out with anything, just spit out any saliva into a cup from your mouth after 15 minutes, then just sit there as you experience the trip for the next 90 minutes, go brush your teeth if you want way later...it does not hurt the tongue, feels completely fine after it's dissolved. It's even good for dental health imho as it kills any bacteria. But your teeth should be just fine, as we are trapping it in the sublingual mucosa under the tongue.

6. 60mg is very powerful...I redosed every 2 hours, this was indeed a level 4 on the Shulgin scale for me combined with 300mg THH taken orally 1 hour before the whole journey, has a half-life of 10.5 hours, so 5 hours of strong activity combined with re-dosing 60mg sublingual DMT every 2 hours = incredibly bad ass, I had 5 hours of brightly colored CEV visions as described above...most powerful CEV visionary experience of my life.

I love it even more than strong cactus tea cause it's dirt cheap to experience a level 5 trip now, and no different than strong cactus tea as open eyed beauty is profound, music sounds INCREDIBLE for 5 hours, and heavy CEV visions for hours on end.

7. Update: This past Friday on 5/21/21, I again took 300mg THH one hour before then used 80mg sublingual DMT complexed this time to 560mg HPBCD, mashed with 11 boiling hot water drops for 2 minutes on a spoon, then held complex under tongue for 15 minutes and experienced open eye visuals this time...the walls filled with colored geometrics & open eyed beauty was again profound...this was my 2nd high dose trial, when I took this again sublingually, but used 80mg instead of 60mg. Again, I had high-powered CEV's as well. I have become adept at using this stuff sublingually now. I had none to re-dose as I ran out of DMT, but at least I got 90 minutes out of it: Music sounded out of this world good and it was a very strong journey. I am now taking a 2 week break before I take it again.

8. Try adding another 100mg of HPBCD to your complex, as the 2-Hydroxypropyl-β-cyclodextrin has a higher molecular weight (1500 g/mol) than my plain HPBCD (1300 g/mol), molecular weight of DMT = 188 g/mol...you want to use a 1:1 molar ratio.

This will help trap more of the DMT, and lower the mild sting threshold even more. Use a 1:8 mg weight ratio of DMT to HPBCD instead of 1:7 mg weight ratio in other words. This means using 60mg DMT to 480mg HPBCD with 10 drops near boiling hot water from a coffee mug all mashed together on a spoon for 2 minutes, then pour under tongue.

Last post of paper has the HPBCD complex spoon pics & part 10: how to make tetrahydroharmine easily:
HPBCD DMT very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca - Pharmahuasca - Welcome to the DMT-Nexus

 

[plumbus-nine]

Thanks for posting. Will certainly try this in future, I've always been curious of DMT but don't like neither needles nor inhaling things which the nose doesn't tolerate, yet this route is appealing

So you could complex e.g. testosterone too?

 

[tregar]

plumbus-nine said:

Thanks for posting. Will certainly try this in future, I've always been curious of DMT but don't like neither needles nor inhaling things which the nose doesn't tolerate, yet this route is appealing

So you could complex e.g. testosterone too?

Thanks plumbus-nine. Yes, it can be used to complex test too, see part 5 of linked to paper above with bloodwork result studies.

 

[Tryptamite]

It could be used to IV non water soluble drugs?

Eg drugs like zopiclone which do not form salts very easily.

 

[tregar]

For the HPBCD DMT experiments, extracted DMT as described below:

1) A procedure (based on Noman's or Norman's tek) which yields 1.5g DMT from 150 gram powdered bark: all 4 pulls are using 90ml naptha on 150g powdered bark mixed into 1.8 liter lye water (1.5 x 150g bark = use 225g lye dissolved into the 1.8 liter 150 degree hot water.) Just heat up 1.8 liter of water in a big pyrex pot on stove and use thermometer to pull if off when it reads 150 degree F.

Slowly sprinkle lye using safety goggles and long chemical resistant gloves that go up each arm, and stand back as far as possible...(the hot water will fizz but not boil up) into your pyrex pot of hot water. After each sprinkle, stir the water a bit with a super long metal spoon. It will "growl" a bit as it fizzes, but this way it dissolves very fast into already hot water.

Pour this lye water into your 2 Liter erlenmeyer flask using a large automotive funnel. Add 150 grams of finely powdered bark, and use a long chopstick or similar to mix it all together.

Use (.6 x 150g bark = 90ml naptha pull for each of the 4 pulls). An erlenmeyer flask makes it easy to do pulls using a long glass pipette, as the top of flask is tapered, so all the naptha collects at the top for easy pull.

Use an electronic thermometer to check the temp of the Lye water bark mix, when the lye water cools down from 150 degree F to around 120 degree F, then it's time to add your 90ml of naptha, make sure your 2L flask is sitting on a mitten or similar...this makes it easy to swirl your flask to mix the contents, make sure you are using the proper rubber stopper number to seal the top of your flask once you turn it upside down then right side up to mix the contents as well.

Prefer to do a combination of swirling and a couple of upside down then right side up turns of the 2L flask, then once right side up, let the rubber stopper out, and let the stopper just barely sit in the flask (not tight), so gasses can exit. After 1/2 hour, all the 90ml of naptha will migrate & collect at the top of the tapered erlenmeyer flask...use your long glass pipette to collect the naptha, that's it! very easy, no mess, and the tapered erlenmeyer flask and glass pipette with round rubber plunger at the end makes it easy to collect the naptha at the top without collecting any lye water by accident. This is the way a chemist can do it.

No need to do a sodium carbonate clean on it, it's plenty clean already.

My procedure:
1) place 60mg of DMT onto a spoon
2) add 1:1 molar ratio of host drug to HPBCD powder, this means 1:7 mg ratio DMT to HPBCD, use a 1:8 mg ratio DMT to HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
3) this means 60mg dmt placed on spoon, then add 420mg of HPBCD on top DMT, use 480mg HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
4) add 10 to 12 drops of very hot near boiling water to the mix from a coffee mug
5) Knead or crush the HPBCD powder into the dmt using the end of a spoon for 2 minutes
6) Take 200 to 300mg tetrahydroharmine orally around 45 minutes before. Then place sticky HPBCD DMT glob (HPBCD powder forms sticky complexes) under tongue for 15 minutes, press down with bottom of tongue the whole time to trap sticky liquid complex in the sublingual mucosa. Be sure to use bottom end of tongue to lick any off spoon that is left behind, you want to get it all.

At end of 15 minutes, spit out any saliva into a cup instead of swallowing. The combination of THH + DMT simulates true Ayahuaasca, but there is zero nausea, zero dizziness, zero queasiness since there is no harmine or DMT going thru stomach and intestines. 10 minutes in there are heavy CEV's of spinning colored geometrics, visions of ancient architecture, animals, aliens, you name it, it seems to tap into the Akashic record of the ether in the Universe, where all past, present, and future is known. Open eyed profound beauty, music sounds incredible, this all lasts for 90 minutes. You can redose more HPBCD DMT by two more times, around every 2 hours if you want.

Erlenmeyer flask tapers towards the top, makes extractions easier using a glass pipette, as all the naptha collects in a narrow band tapered area near the top.

 

[tregar]

Update 5-27-2021 p.s. I had an experience last night that blew my mind again for 90 minutes, took 300mg THH 45 minutes orally before as usual...then used 80mg DMT complexed to 560mg HPBCD all mashed together real hard on a spoon for 2 minutes using 11 drops near boiling hot water from a coffee mug. I used the end of another spoon to mash it all together. My new improved method is grab all the liquid complex off the spoon using only the bottom of my tongue to grab it all, as it will all come off spoon and "stick to bottom of tongue". So easy and quick and efficient.

I held it sublingual "under tongue", and the walls filled with geometric patterns, and I saw waves of neon splashes of color wash across the room, it was AMAZING, I was tripping so hard...level 5 again on Shulgin scale, I LOVE this stuff...it's worth the initial sting for 15 minutes, then the sting subsides over the next 10 minutes to nothing. I spit out any saliva at end of 15 minutes, but don't rinse out mouth with anything (any residual amount will keep on absorbing), the sting and numbness is gone 10 minutes later...love this more than strong cactus tea, as it is dirt cheap to experience a level 5 trip now.

 

[tregar]

In the 7 times I have used this sublingually, only twice did I produce more than my normal low amount of less than 10 to 15ml saliva, but it still did not bother me, but I was happy to spit it out at 15 minutes. I have noticed on subsequent re-doses during the night, that there is even less saliva and sting as the mouth/tongue gets used to it.

On wed night 5/26/2021, I had an experience that blew my mind again for 90 minutes, took 300mg THH 45 minutes orally before as usual...then used 80mg DMT complexed to 560mg HPBCD all mashed together real hard on a spoon for 2 minutes using 11 drops near boiling hot water from a coffee mug. I used the end of another spoon to mash it all together. My new improved method is grab all the liquid complex off the spoon using only the bottom of my tongue to grab it all, as it will all come off spoon and "stick to bottom of tongue". So easy and quick and efficient.

I held it sublingual "under tongue", and around 12 minutes in, the walls filled with geometric patterns, and I saw waves of neon splashes of color wash across the room, it was AMAZING, I was tripping so hard...level 5 again on Shulgin scale, I LOVE this stuff...it's worth the initial sting for 15 minutes, then the sting subsides over the next 10 minutes to nothing. I spit out any saliva at end of 15 minutes, but don't rinse out mouth with anything (any residual amount will keep on absorbing), the sting and numbness is gone 10 minutes later...love this more than strong cactus tea, as it is dirt cheap to experience a level 5 trip now.

Don't forget if you don't like the sublingual method, you can always use this stuff orally, as it performs many factors better than DMT freebase or DMT salts used orally, see the trip report I did back on 5-12-21. Example: HPBCD improves oral absorption profile for Ofloxacin, a second generation fluroquinolones by 54 to 89 percent. But I love the sublingual method personally.

Dennis Mckenna Ph.D: page 115 "Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron."

I still can't get over the visuals on wed night: I saw entire waves of neon color that extended from bottom of floor to top of ceiling wash all the way from the right of the room to the left of the room, like a laser scanner, there were fine "ripples" in the waves...these waves were broadcast onto the walls, replacing the fine geometrics already seen on the walls...the neon colors were out of this world impossible: neon red-greens, neon orange-blues, neon purple-yellows.

The euphoria and open-eyed beauty was over the top for a full 90 minutes. The music being played over the 3.5 foot high infinity speakers I've had for so many years sounded incredibly good, like being an alien experiencing sound & music for the very first time.

I had so much fun, I re-dosed again with a lower 60mg around every 2 hours. ZERO nausea, ZERO dizziness, ZERO queasiness feelings. AND IT STILL KEPT WORKING BAD ASS. I work some weekends, so that's why I took it Wed night, as I have random 2 days off in a row midweek some weeks. As a weightlifter, I'm used to experiencing "the burn" in the muscles when lifting, so to me the sting under the tongue is tolerable, does not bother me, for some others, they will want to experience this orally using harmine and thh taken at same time mixed with the HPBCD DMT (which turns 100% clear when it hits the hot water) all together in a 2oz hot water tea, just like I have done once before on 5-12-21, +5 trip as well.

 

[tregar]

This is the story of how this came about: the plants taught this to me. I did not discover it. I have taken Ayahuasca over 70 times and cactus tea x 200 times. Ayahuasca seems to want to propagate herself all over the globe by any means possible, and if that means using the latest pharmacology advancements such as HPBCD, then so be it. The planet is in crisis, and Ayahuasca wants to help reverse the insane rapid destruction.

Daniel Pinchbeck "How Soon is Now":

The human race is careening toward extinction: rising acidity of the oceans threatens coral reefs, habitat destruction, non-native species (predatory fish, bullfrogs, fungus, pathogens), climate change (alters temperature and water levels), pollution and diseases (especially chytridiomycosis, caused from the chytrid fungus) all have been shown to contribute to worldwide amphibian declines.

We clear forest that are full of trees even though we continue to pump CO2 into the air even though we know it's heating up the ozone and melting ice caps; we clear forests that are full of trees that could potentially help clean that co2 out of the air, the Amazon rainforest is the lungs of the planet, but miles of it are slashed & burned every week so that cattle can graize there instead to make hamburgers, and massive soybean cultivation. We throw away plastic water bottles, and worst of all, we feed into the corporate systems that keep this destruction going.

I don't know about you, but I don't use soybeans for anything, don't eat hamburger or steaks, only fish, chicken & turkey daily, as a bodybuilder this keeps me lean daily.

On my 70th Ayahuasca journey using the very last of my stored away Hawaiian psychotria, she showed me a vision of my "lost 1kg container of HPBCD". I had put it away 12 years ago, as I bought it from a sports supplement supplier, once pro-hormones became illegal, I carelessly abandoned the container in a place I could care less about, see pic on post #1.

Ayahuasca has a long standing traditional reputation of helping people find lost personal items like rings, necklaces, etc. through visions. She once helped me find a set of important spoons that I had misplaced many years ago as well. She showed me they were buried in a drawer under forgotten clothes many years old. I once saw a vision of a beautiful woman in medieval times searching for a lost ring in her home, Ayahuasca showed me that it was at the very top of a cubbard in her kitchen.

All that time the HPBCD container was lost, she showed me that it was in my garage buried in a container along with plumbing parts. That night I dug it out of the container and put it in my closet for use the next day. She also showed me a vision of the mimosa tree or shrub, I put 2 and 2 together, and knew what she was telling me...to experiment with HPBCD complexed DMT, and so that is what I did. She already knew that I had experience making sublingual HPBCD pro-hormones, as I had learned it from chemist Patrick Arnold.

I had run out of Hawaiian psychotria, and it had been extinct for the past 3 years, perhaps diverted to all the numerous Ayahuasca centers in South America. I needed a high power alternative.

Daniel Pinchbeck "Breaking Open the Head" (Daniel also states in his book, that Ayahuasca is his favorite entheogen):

For many people, Ayahuasca-a slowed-down low-res interface of the DMT flash-seems to convey strong messages from the natural world, of nature as sentient energy and spirit matter, of the need to protect the planet we have been given.

Yage whispers that human beings are meant to be gardeners of this reality, journeyers, storytellers and singers, weavers of the sacred. DMT, on the other hand, conveys no overt human or humane message.

Graham Hancock, "Supernatural", pg 428:

My experience with smoked DMT was qualitatively different from the realms and beings Ayahuasca introduced me to. For whereas the Ayahuasca worlds seemed rich, luxurious, and abundant in the transformations of organic and supernatural life, DMT brought me to a world--or to some aspect of a world--that appeared from the outset to be highly artificial, constructed, inorganic, and in essence technological.

A little bit about me...

Becoming a shaman is often just as much of a curse as it is a blessing. Shamans are chosen by the Spirits at birth, but it is not until later in life (usually in their 20’s) that the shaman is struck down. The striking down of a shaman is to dismember them as a person and to have them reborn into something else.

I am not a shaman, but have been thru alot of the near-death experiences Shaman's have gone thru, lost both my twin girls at birth, so have no children, my beloved pet Shitzu died at only age 4 from continuous bladder stones for 6 months, we did everything together...he was unable to pee so many times, we had to rush him to vet, where he was put down. He visited both of us in a dream 2 days later to tell us he was doing great in Heaven with a big smile on his face.

Have nearly died several times, once was hit head on by a truck when driver ran a yield sign, barely survived with numerous injuries. The hospital caught all my fractured ribs but did not diagnose my collapsed lung, so when I got home, drifted into shock in the middle of the night, wife called an ambulance and was rushed to a better hospital where they immediately diagnosed the lung condition and treated me for it.

Once took alot of acacia bark with Ayahuasca instead of the normal Hawaiian psychotria I use, and went into a serious serotonin syndrome shock, for an hour and a half I sweated my ass off sitting in the bathtub, I told my wife goodbye while my dog watched in a sad state...by some miracle pulled out of it, believe it was the high levels of maoi's in the acacia that interacted with the rima's in the Ayahuasca, bad combination. My forehead was pouring sweat for 1.5 hours, was in severe shock and trembling, and knew I was gonna die.

Lost everything in a 100 year severe flood, my home and all my belongings, had just gotten married to my beautiful wife and all the newlywed gifts perished...right after that we moved to an apartment complex, and 5 months later all our belongings again perished as they burnt to the ground after a disgruntled teen threw a lit blunt into the apartment complex after his girlfriend dumped him.

Had it not been for the policeman banging on the door of the apartment, we would have surely burned in the flames, as we were on the 3rd floor & asleep as I worked 2nd shift at the time. We ran down the steps in only our bare feet and suffered smoke inhalation.

Have been thru some near-death experiences similar to a Shaman, who lives on the outskirts of society. Lifting weights, walking in nature with my dog, going to the waterpark with a season pass every summer, and reading Bible all keep my spirits up.

Some of you have contacted me via messenger to let me know that you would like to experience this for other reasons than the visions, to help with treating depression. I will tell you this, yes, Ayahuasca can help to cure not only anger issues, melancholy, drug abuse & addictions, but also depression. She is also able to grow brand new neurons in the brain every time a journey is taken, she has cured people of all sorts of afflictions and ailments, even severe depression. I feel an afterglow for a couple days after a journey, and this refreshed serotonin reset often lasts for a couple weeks.

Celebrities who have battled major depression: Dwayne Johnson "the Rock", Katy Perry, Jon Hamm, Lady Gaga, Michael Phelps, Kristen Bell, Bruce Springsteen, Gwyneth Paltrow, Ashley Judd, Naomi Judd, Ryan Phillippe, J.K. Rowling, Sheryl Crow, Terry Bradshaw, Buzz Aldrin, Tipper Gore, Wayne Brady, Jim Carrey, Robin Williams, Brittany Murphy.
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A little bit more on tetrahydroharmine:

1) She has very strong serotonin blocking action, which results not only in stimulation but powerful transcendence as the daily survival filters are lifted so that "mind at large" as coined by Aldous Huxley can be let loose, when combined with DMT, which does not block serotonin on it's own, you then get the "full monty" mind expansion powerful transcendence. See end of post #41 for journey reports of 300mg THH on it's own. THH has numerous similarities to mescaline as noted by not only myself, but another person here. I have seen the receptorome data for THH, which not only blocks serotonin like mescaline, but agonizes all 3 of the adrenal receptors just like mescaline which are associated with powerful visionary activity, perception of beauty and aesthetics.

2) Yes, she is feminine, which is why I always associate feminine pictures and energy with my journey trip reports that involve her. Queen of the Forest is what I like to call her.

3) She seems to be very stable indefinitely. I've used THH that was many years old that I had lost, still worked exactly the same. Wikipedia to find out more about it (good page on it), or read attached paper two posts up attached. Even Shulgin remarks in the book TIHKAL that "studies on THH are absolutely imperative." He also remarked that it probably holds one of the keys to unlocking Ayahuasca, but we just didn't know it yet.

4) Please just take tetrahydroharmine orally between 150 to 300mg. She causes no dizziness at 250mg or below, and only a tiny bit at 300mg, but once you are used to her, no dizziness even at 300mg. ZERO nausea, ZERO queasiness, so just consume THH orally at a powerful amount found in normal Ayahuasca brew which if you read attached paper two posts up is at least 150mg.

Many take multiple cups of Ayahuasca, so the THH is additive in effect, with a half life of 10.5 hours, so you get 5 hours of super strong effects, once you reach 300mg, the powerful CEV visions are seen for hours on end, phenomenal, them combine with DMT and the visions multiply and become colored and even brighter, as THH visions alone are monochrome (one-color) usually in green or blue. The DMT adds color and brightness to the visions, and adds to them exponentially.

Pics here: HPBCD DMT very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca - Pharmahuasca - Welcome to the DMT-Nexus

 

[tregar]

I plan on having another neon-colorful open eyed trip like post #57 next weekend, so I'm not only taking 250mg THH with me for oral use 45 minutes before, but I pre-made a HPBCD DMT tincture to take with me when I go to the beach for 4 days next week. I'm cheaply renting a house with pool a few blocks down from the beach as we pooled our funds together with another couple we know. The tincture will stay good in fridge for several days, but after several days it needs to be stored in a freezer so bacteria does not grow.

Each 0.5ml on the graduated pipette (10 drops) = 60mg HPBCD DMT (60mg DMT complexed to 420mg HPBCD in 10 drops near boiling hot water from a nearby coffee mug)

Note: add 1:1 molar ratio of host drug to HPBCD powder, this means 1:7 mg ratio DMT to HPBCD, use a 1:8 mg ratio DMT to HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin. This means 60mg dmt placed on spoon, then add 420mg of HPBCD on top DMT, use 480mg HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.

I dunk the tincture bottle in a coffee mug of near boiling hot water to warm it up again before use after pulling from fridge or freezer. Each drop = 6mg DMT complexed to 42mg HPBCD.

HPBCD is itself very soluble in water (greater than 1000 mg/ml at room temperature). This increases with VERY HOT near boiling water. So now you see how I used in earlier trip 80mg DMT complexed to 560mg HPBCD in 10 to 12 drops for sublingual use. 1ml = 20 drops, 0.5ml = 10 drops, therefore each drop of water can hold 50mg HPBCD at room temp, or twice that 100mg HPBCD in very hot water.

pic here: https://www.dmt-nexus.me/forum/default.aspx?g=posts&m=1107014&#post1107014