Interesting that you wanted to do heroin for depression. Not that one way is right and one way is wrong, just with my depression I have always gone the opposite direction to medicate with drugs.
I understand him otherwise, that he had depression and post acute withdrawak / probably anhedonia from tramadol use and now that these symptoms have increased, he decided not to try H.
| Opioids can indeed be antidepressive, specially at first but and in some cases for long time - if anxiety, regret, sadness are the core and strong enough to cause depression. But its thin ice to realize what's euphoria related (and that WILL go away). But opioids come with their own kind of depression, they suppress hormone production leading to lethargy, low energy, social withdrawal in some cases. If you suddenly realize not being able anymore to handle work, or have no energy for favorite hobbies, friends, family and on top of all the constant pressure to source the next baggie of brown earthy powder..
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I am taking opioids for chronic, treatment resistant general anxiety, deep regret and empty/loneliness - but I have the luck of medical supply, this way it works but stil comes with depression. Not the sad, anxiogenic, empty depression but one as the literal sense of that word. It doesn't feel bad but stands in the way of future, and it is well possible that I
will not be able to live without opioids again for a long time (Therapist said maybe for life, which is possible.)
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Still, sorry for repeating, I need to add that withdrawal doesn't need that horrible scenario seen in movies or possibly with friends etc.. with NMDA receptor antagonists (free in many countries: DXM. What can work like magic but needs Rx: memantine) taken during the time when your body re-adjusts and you'd undergo physical withdrawal, they suppress most of the discomfort. Add some loperamide against diarrhea and non-druggies possibly wouldn't notice.
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Graph lines: methadone dose. above: with placebo. below: with memantine
5mg when 20mg are recommended for elderly people (old, main indication of memantine is neuroprotection in Alzheimer's), in clinical trials 40-60mg were used and here on BL are people who used twice that dose. It's a remarkably safe substance.
- They used jusy 5mg doses of memantine, thus long delay before effects.Higher means less waiting time & when you switch off the opioid after a few days, instead of feeling shitty, you'll feel how your body starts to produce own testosteron.
- Insomnia is possible, maybe then lower the memantine dose slightly, or that DXM is better suited for you - it is stimulting too but in low doses like 120mg 2x/d it will let you sleep. Maybe melatonin could help to re-adjust the messed up circadian rhythm.
- I did this, twice now, both time without feeling classical withdrawal symptoms. It's easier to go off 200mg morphine this way than in clinics from buprenorphine. I don't get why it's well documented but no clinic uses this method. The papers suggest also an acceptable security btw, and it's been trialed in human.