Sorry to bump this oold Thread but i am a rapid metabolizer with methadone ,yet get NOTHING out of codein and barely to nil from DHC except unwanted sides like red face. My oral MSer dose is max to what they allow or it wouldnt hold me 24h. I take cimetidine cuz of exactly that. How can i then be a poor metabolizer AND a fast one at the same time if no cimetidine in play???? And fluoxetin would help more than cimetidine?? Worth a try? If anyone could clear that up i'd be very grateful!!!!
Harm Reduction ⫸DANGEROUS Drug Combos⫷
- Thread starter kleinerkiffer
- Start date
Fiori di Bella
Bluelight Crew
- Joined
- Mar 24, 2020
- Messages
- 2,952
Thanks for asking, yes, I’m totally fine.
What’s interesting is that I get all of those prescriptions from the same doctor, with the exception of Vyvanse and the alcohol. I think I learned my lesson.
TumajNuri
Ex-Bluelighter
- Joined
- Dec 9, 2015
- Messages
- 985
Seizures and spams are common side effects of tramadol overdose. Some tramadol users think that redosing would enhance the euphoria and then they experience spasms that sound scary and can be avoided by anti-seizures (such as benzos)
Note that it's my own opinion. Plz do not combine trama with other drugs unless u have the idea of what u are doing. According to my personal exp. Benzos can overcome the spasms/seizures but could also put an end to euphoria caused by Trama.
Last edited:
CuriosityMonster
Greenlighter
- Joined
- Aug 20, 2017
- Messages
- 15
This is purely anecdotal and also likely redundant since we know the dangers of SSRIs+(most) stimulants, but since many people ignore these dangers - myself included - and even do so without ill effect (serotonin syndrome) I feel it is relevant to mention. Perhaps it might help somebody.
A friend and I are prescribed 20mg of paroxetine which we take every day. We took over the course of 11-13 hours 450-550mg of methamphetamine - a drug we had never tried before - and shortly after the last dose - we finished our halves at approximately the same time - we began experiencing serotonin syndrome. This is not something that particularly surprises me - paroxetine is an SSRI and methamphetamine is a powerful serotonin-influencing stimulant. However, we both have taken many, many different stimulant drugs - including amphetamine - whilst on 20mg of paroxetine without ill effect. We've insufflated grams of cocaine, smoked crack (for the first time), taken huge doses of LSD - all without any problems related to serotonin syndrome. I am merely stating this for reference: do not do drugs and if you do don't do large amounts or take them with drugs that dangerously interact with them.
Therefore I think it is possible that methamphetamine - again, this is purely anecdotal, but it did happen to both of us in the same manner and it makes logical sense - is more likely to trigger serotonin syndrome than many if not all other drugs. I don't think it's an unlikely theory to be true that a drug as powerful as methamphetamine that strongly and directly interacts with serotonin receptors in the brain, which involves (likely) acute neurotoxicity of these receptors - something other drugs do not do - would be a particularly dangerous combination paired with SSRIs, which also directly interact with serotonin receptors. Certainly, my friend and I will not be doing this drug again, or at least not if we're still taking any SSRI drug.
I also think taking any different drugs (meth and paroxetine in this case) which both interact strongly with the same receptor in the brain (again, other drugs are not directly neurotoxic in the brain) in vastly different manners is a bad idea inherently, perhaps as harmful in the long-term as serotonin syndrome is in the short-term. Why take an SSRI which influences serotonin receptors in a positive way to make you feel better and also methamphetamine which increasing evidence suggests is ACUTELY toxic and damaging to these same receptors? You might as well not be taking the SSRI if you're going to do that.
TL;DR: Don't take SSRIs and stimulants, but perhaps think extra hard about taking SSRIs and meth; it's potentially extra dangerous in the short-term and in the long-term would make the reason you're taking SSRIs redundant.
A friend and I are prescribed 20mg of paroxetine which we take every day. We took over the course of 11-13 hours 450-550mg of methamphetamine - a drug we had never tried before - and shortly after the last dose - we finished our halves at approximately the same time - we began experiencing serotonin syndrome. This is not something that particularly surprises me - paroxetine is an SSRI and methamphetamine is a powerful serotonin-influencing stimulant. However, we both have taken many, many different stimulant drugs - including amphetamine - whilst on 20mg of paroxetine without ill effect. We've insufflated grams of cocaine, smoked crack (for the first time), taken huge doses of LSD - all without any problems related to serotonin syndrome. I am merely stating this for reference: do not do drugs and if you do don't do large amounts or take them with drugs that dangerously interact with them.
Therefore I think it is possible that methamphetamine - again, this is purely anecdotal, but it did happen to both of us in the same manner and it makes logical sense - is more likely to trigger serotonin syndrome than many if not all other drugs. I don't think it's an unlikely theory to be true that a drug as powerful as methamphetamine that strongly and directly interacts with serotonin receptors in the brain, which involves (likely) acute neurotoxicity of these receptors - something other drugs do not do - would be a particularly dangerous combination paired with SSRIs, which also directly interact with serotonin receptors. Certainly, my friend and I will not be doing this drug again, or at least not if we're still taking any SSRI drug.
I also think taking any different drugs (meth and paroxetine in this case) which both interact strongly with the same receptor in the brain (again, other drugs are not directly neurotoxic in the brain) in vastly different manners is a bad idea inherently, perhaps as harmful in the long-term as serotonin syndrome is in the short-term. Why take an SSRI which influences serotonin receptors in a positive way to make you feel better and also methamphetamine which increasing evidence suggests is ACUTELY toxic and damaging to these same receptors? You might as well not be taking the SSRI if you're going to do that.
TL;DR: Don't take SSRIs and stimulants, but perhaps think extra hard about taking SSRIs and meth; it's potentially extra dangerous in the short-term and in the long-term would make the reason you're taking SSRIs redundant.
Last edited:
S.M.F.G
Bluelighter
- Joined
- Mar 5, 2008
- Messages
- 2,137
Worst mistake I've made in a long time from what happened and the searching for interactions between opiates and this baclofen we stumbled upon 20mg tablets my company took 60mg and took only 150 mg of codeine, and I took 80mg baclofen with my 360mg of codeine had a litre of beer (3-4standard). Then decided that a Xanax would possibly be too much so didn't touch it, 30 to 40 minutes later I am falling over dropping drinks excessive sweating fucked up bad I vomited about 3 times wandered off in a daze got something to eat returned ate vomited I then tried to flip down with up and have a good point to get my shit together and I'm now 15 hours later headache feel like horrible as hell upset stomach and can say that was a bad mix I have been alright to look at this online and know I should have looked at this baclofen more as my gf( who took the lesser) and had same symptoms and dropped and had a siesure now feeling those after effects and both of us are not feeling too awesome at all, my tolerance with pharmaceuticals is higher with what I take, when stocked, Valium, lyrica, Seroquel and Xanax to top I am lucky to have not had those on top as I am sure that I just fucked up and this was pretty dangerous and never get into that again. And with the other ones I could well have taken a fatal mix.
kratom (8g) and half blunt of k2 (5f-mdmb-pinaca already mixed with tobacco) , nearly got me killed from respiratory depression, its like heroin overdose , i had to force my brain to not stop breathing , i didnt have any narcan at the time , so i puke the kratom out and drank a lot of water and put myself into a recovery position. after 3 hours or so of hell everything went down and i felt better , watchout guys.
Bomb319
Bluelighter
- Joined
- Nov 26, 2011
- Messages
- 583
Thanks so much for your service to the HR community. The only thing puzzling me - and very sorry if it's already been discussed, as I just skipped straight to the bottom of the thread, is PCP. I would definitely consider it to be a dissociative and not a hallucinogen, though it definitely causes "true" hallucinations like all dissociatives; this means a user truly does NOT know whether or not what he or she is seeing is reality. Shrooms, LSD and typical serotonin-based hallucinogens technically produce pseudohallucinations in the user. They are aware of the anomaly in their perception and recognize it for what it is. High doses of dissociatives on the other hand can produce nightmarish constructs which are indistinguishable from reality to the user.
EUPH0RiCRUSH
Greenlighter
- Joined
- Apr 8, 2021
- Messages
- 11
Your overdose is more related to the benzos. Let's not try to demonize methadone. Obviously, if you take 50mg the first time every you may OD. That's like doing an oxy 80 the first time or a 3bags the first time of decent dope. You say you were fine most of the time, well yeah, I'd hope you didn't OD the majority of the time lol. Point is, it sounds like your giving the benzos a pass & blaming it on the methadone. The methadone was fine, it was the benzos that put it over the edge. No benzos should be taken with opiates even if you are fine most of the time.
Beetle 6989
Bluelighter
- Joined
- Apr 10, 2021
- Messages
- 79
What is Cyp2d6
Jabberwocky
Frumious Bandersnatch
- Joined
- Nov 3, 1999
- Messages
- 84,998
I don’t know about consensus (or coke), but I know from experience and from some other online reports that both alpha and beta blockers as well as other drugs that reduce blood pressure can cause a hypotensive crisis if you are really peaking on amphetamines.
Other drugs in the mix like some antipsychotics (eg seroquel) magnify the risk significantly.
Beetle 6989
Bluelighter
- Joined
- Apr 10, 2021
- Messages
- 79
Thank you for the def
I took an atenolol Seroquel alcohol and did meth before went to bed woke up 8 hours later and had a hypotensive episode. I almost went to the ER and eversince I'm having problems.
nausea
Greenlighter
- Joined
- Jun 27, 2021
- Messages
- 1
Does psilocybin have interaction between tizanidine(sirdalud) and is it safe together?
I tried to read about the whole damn internet without luck.
I got really bad insomnia and if i want to try shrooms i got to worry when did i eat the last time tizadinine or can i take it at the same night. I use it very often 6mg to fall asleep.
I also take once in a while seroquel 25-50mg but not so often and it doesnt matter anyway at low dose and is also suitable even to take at same night if needed after shrooms.
Also i dont know why would i do it but if necessary is it ok to take shrooms and later sirda+seroquel.
Thanks.
I tried to read about the whole damn internet without luck.
I got really bad insomnia and if i want to try shrooms i got to worry when did i eat the last time tizadinine or can i take it at the same night. I use it very often 6mg to fall asleep.
I also take once in a while seroquel 25-50mg but not so often and it doesnt matter anyway at low dose and is also suitable even to take at same night if needed after shrooms.
Also i dont know why would i do it but if necessary is it ok to take shrooms and later sirda+seroquel.
Thanks.
mr peabody
Bluelight Crew
- Joined
- Aug 31, 2016
- Messages
- 5,714
Maybe have a look here : INSOMNIA
opiofr3k
Bluelighter
- Joined
- Jul 18, 2021
- Messages
- 140
Back in the day's it was not a problem but now if i will take even tiny line of coke or speed after taking before tramadol(100-150mg) after sniff i feel anxious and i have to take at least 5mg diazepam under tounge cause i'm getting feeling that it won't end good. Is it only in my head or really so small doses in a mix can cause any issues? I'm 34 years old, atm im addicted only to weed, opio or stims only occassionaly but my experience specially with pharmacy drugs is huge during my life time 
That's why im surprised it goes almost always wrong. I know best solution is to avoid stimulants and that's what im planning to do, just want a opinion about it what's exactly going on. Thanks in advance!
That's why im surprised it goes almost always wrong. I know best solution is to avoid stimulants and that's what im planning to do, just want a opinion about it what's exactly going on. Thanks in advance!Cautiously Testing
Greenlighter
- Joined
- Jul 26, 2021
- Messages
- 6
Hello all, just registered today and slowly reading threads for answers to a few questions. I'll try to keep this brief.
EDIT: It's not. Sorry
I noticed it was posted that stimulants shouldn't be combined with propranolol. Short history is that for about 10 years I've been taking (prescribed) 180mg of propranolol and 2x30mg of Adderall daily. Of course, everyone's body chemistry is different but I've never had nor heard of an interaction problem. Also, before being diagnosed with ADD I was on a metric shit-ton of antidepressants and mood stabilizers for mis-diagnosed bi-polar. (They have many of the same symptoms.)
Anyway, the Adderall was a godsend as it finally, at age 35 opened a whole new world. It's the best thing to happen to me as far as work, money management, relationships, drinking, etc. This was after trying Strattera, Concerta, Vyvance and Wellbutrin. Plus I can actually think without having a thousand different thoughts vying for attention every second.
When I was completely dry there were times I'd take a 30 every 4-5 hours or so and stay up, coherent, productive and most importantly not BORED for 3 or 4 days. If it's relevant those were the XR. I'm on the generic now. IR I assume. The funny thing though, is I've always been able to take one in the morning and, given the chance, couple lay right back down an hour later and fall asleep easily.
Now I drink. Often. Daily. Up to a case of beer a day. Taking 2 or 3 Adds seems to make me even more sleepy after a few hours. About 3 weeks ago the woman I'm dating offered some of her coke. First time I've ever tried it and it made me feel very relaxed. Just wanted to sit on the couch and watch TV. Didn't feel any sort of euphoria it anything I've heard of it's use. Tried snorting an Add but still didn't really feel anything.
(I probably should've broken all this up into a few posts over different forums, but I'm on a roll now so WTH?)
So I guess the questions are:
Why not mix betas with stimulants?
I know stimulants help calm people with ADD. But seriously, Adderall mixed with cocaine and I don't get high? Alcohol I assume, but it's EXTREMELY rare I get drunk since it's kinda weak beer and over the course of a full day. So don't picture someone bleary-eyed passing out. Usually if you can't smell it on me you'd have no idea I was drinking.
Am I just destined to never feel a coke high since being a stimulant it'll just naturally be a calming agent? Secretly I hope so cuz the shit is expensive. But damnit, I want to feel it at least once in my life!
EDIT: It's not. Sorry
I noticed it was posted that stimulants shouldn't be combined with propranolol. Short history is that for about 10 years I've been taking (prescribed) 180mg of propranolol and 2x30mg of Adderall daily. Of course, everyone's body chemistry is different but I've never had nor heard of an interaction problem. Also, before being diagnosed with ADD I was on a metric shit-ton of antidepressants and mood stabilizers for mis-diagnosed bi-polar. (They have many of the same symptoms.)
Anyway, the Adderall was a godsend as it finally, at age 35 opened a whole new world. It's the best thing to happen to me as far as work, money management, relationships, drinking, etc. This was after trying Strattera, Concerta, Vyvance and Wellbutrin. Plus I can actually think without having a thousand different thoughts vying for attention every second.
When I was completely dry there were times I'd take a 30 every 4-5 hours or so and stay up, coherent, productive and most importantly not BORED for 3 or 4 days. If it's relevant those were the XR. I'm on the generic now. IR I assume. The funny thing though, is I've always been able to take one in the morning and, given the chance, couple lay right back down an hour later and fall asleep easily.
Now I drink. Often. Daily. Up to a case of beer a day. Taking 2 or 3 Adds seems to make me even more sleepy after a few hours. About 3 weeks ago the woman I'm dating offered some of her coke. First time I've ever tried it and it made me feel very relaxed. Just wanted to sit on the couch and watch TV. Didn't feel any sort of euphoria it anything I've heard of it's use. Tried snorting an Add but still didn't really feel anything.
(I probably should've broken all this up into a few posts over different forums, but I'm on a roll now so WTH?)
So I guess the questions are:
Why not mix betas with stimulants?
I know stimulants help calm people with ADD. But seriously, Adderall mixed with cocaine and I don't get high? Alcohol I assume, but it's EXTREMELY rare I get drunk since it's kinda weak beer and over the course of a full day. So don't picture someone bleary-eyed passing out. Usually if you can't smell it on me you'd have no idea I was drinking.
Am I just destined to never feel a coke high since being a stimulant it'll just naturally be a calming agent? Secretly I hope so cuz the shit is expensive. But damnit, I want to feel it at least once in my life!
Jabberwocky
Frumious Bandersnatch
- Joined
- Nov 3, 1999
- Messages
- 84,998
I’ve done a bit more reading on this and it seems there has been a longstanding ER dogma about the risk of “unopposed alpha stimulation” from giving beta blockers in the case of stim toxicity. This is supposed to cause a spike in blood pressure and possibly tachycardia and other complications. It was thought more an issue for coke than meth, but plenty of doctors believe it for meth too.
However, it seems that unopposed alpha toxicity is only hypothetical. The science behind it makes sense but there is negligible evidence of it ever occurring with amphetamine. However beta blockers are sometimes contraindicated with cocaine users if they have already suffered heart damage.
As of 2020, the first line treatment of amphetamine toxicity remains benzos (usually valium). Second line is an antipsychotic (usually Haloperidol). The other option is nitroprusside for extreme tachycardia with hypertension.
If sedation does not reduce tachycardia with hypertension then the combine alpha-beta blocker labetalol is recommended. If there is tachycardia without hypertension then the straight beta blocker metoprolol is recommended.
Calcium channel blockers are not contraindicated for meth toxicity but are far less effective than beta blockers.
Cautiously Testing
Greenlighter
- Joined
- Jul 26, 2021
- Messages
- 6
Thanks for the info Perforated
Redize1111
Greenlighter
- Joined
- Aug 2, 2021
- Messages
- 2
I'm new to this but was wondering how bad taking 1mg of Ativan in the morning then drinking a pint of vodka at night. Any advice
Cautiously Testing
Greenlighter
- Joined
- Jul 26, 2021
- Messages
- 6
I've taken 3 or 4 with a beer after drinking all day and never felt it. Though I have a high tolerance to alcohol and, of course, everyone's body chemistry is different. I can't imagine that combo would be any worry. But again, I'd have absolutely no problem drinking a pint before going to work so YMMV.