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Harm Reduction ⫸DANGEROUS Drug Combos⫷

Tweakerdumb

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Dec 29, 2017
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NC
Hypothetically speaking, how long would someone have to wait to start taking their prozac again after 3 month meth relapse?
 

Scrofula

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Hypothetically speaking, how long would someone have to wait to start taking their prozac again after 3 month meth relapse?

Hypothetically, one wouldn't have to discontinue their fluoxetine/Prozac during a meth binge in the first place. Wait time: -3 months. You could start it up today if you want. I mean, someone could. I'd discourage it, separate from any meth issues, as SSRIs are on my shit list. Permanently this time.

Yes, some will say there's a chance of serotonin syndrome combining the two, but you're going to hear that about every central-acting substance, whenever one's taking a serotonergic drug. But meth's serotonergic action is indirect and nearly non-existant, and the odds are much higher for getting hit by a bus while looking down at your bottle of Prozacs while trying to remember if you took your daily dose that morning.

Meth would be "out of your system" in about five days, if that's what you wondered. Or did you have a different concern (ie., other than serotonin syndrome) about combining them?
 

lindsgoldilocks

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Mar 16, 2018
Messages
15
I take 1200 mg gabapentin every day for nerve pain. It helps the pain and gives me a dry mouth and thats all. I also take flexeril, 60mg cymbalta, trintillex and vistaril. Sometimes norco, and sometimes clonazepam. Get epidural injections in my back due to an injury with severe residual nerve pain
 

Scrofula

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Vistaril/hydroxyzine is just an antihistamine, usually; Flexeril is cyclobenzaprine, which is a muscle relaxer, not the stuff in the Benzedrex inhalers, like I always thingk; Cymbalta is duloxetine, for nerve pain and also a tricyclic antideressant; Trintillex is vortioxetine, another antidepressant; Norcos are just Vicodins, and clonazepam is Klonopin, a benzo.

The gabapentin I doubt many people could detect underneath all that sedation. I'm sorry for your pain, but this is more intended to ask "is this/could this be dangerous?" or alert us to newly discovered dangerous interactions. Nothing here leaps out, even with all the downers. Is there some concern you had?
 

mando86

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Joined
Jan 17, 2018
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1
Hi new to this group so sorry if Av joined into someone ealses chat. I've been taken drugs on n of mostly on for 15 years.. Av came of a 120 a day pill addiction (hardest thing I've ever went through) but just smoked weed took 40mg of valium is it safe to take cocain on top of that or Am I wasting my time. Any help appreciated. X
 

Scrofula

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120mg a day? 120 pills a day? Of what?

40mg of Valium/diazepam is a bit heavy but not even on the radar of our benzo enthusiasts on site.

Now, adding coke to it you worry might be a "waste". Do you mean wasting drugs, or money, cortisol, time with the living, or you just don't want to get too wasted since you're scheduled to pilot multiple Florida-Boston domestic flights in the morning, from Ireland and/or Scotland?

The usual issue with mixing uppers and downers is one wears off before the other, and being surprised to find you'd overdosed on one of them. But, cocaine is famously brief, and diazepam pretty long-lasting, as drugs go.

I can't imagine they'd make some kind of special in-between sparks, like you won't get a nice Valium nap while grinding your teeth, but it's not something that'll kill a healthy person. I probably do know this feeling, just didn't bother with forming a memory of it.
 

saramajara

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Sep 8, 2012
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baltimore
not sure if this is the right place to post this but has anyone else heard of or tried the east coast methadone cocktail? its extremely popular in baltimore, and i think may be around in new jersey and new york a little bit. anyways its a crazy and dangerous combination

1. methadone dose (usually from clinic) if youre not a daily methadone user this WILL kill you.
2. some kind of benzo, preferably a xanax bar
3. .3mg clonadine (they sell them as "deens" on the street)
4. 25-50mg promathezine (they sell this is "finnegans" on the street)

it will put you on your ASS, or kill you.

i know people in baltimore know about this, but it is popular or even heard of anywhere else in the world?
 

Scrofula

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They really call clonidine "deens" in Baltimore?

If this is a cocktail, what, they dissolve it in some gin, add some tonic, a little lime? They always throw four pills in a little baggie and everyone takes all four at once every time? If they only have 1mg Xanax, do they make sure they give you two every time?
 

Nightraver

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Aug 29, 2016
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664
I read in the first page that it?s dangerous to take coke on any kind of seizure medication
Well I?m prescribed gabapentin for chronic nerve pain and I?m some what of a enthusiast of them but I?ve heard of it being prescribed as seizure med so was wondering if that means they are a bad mix then
 

Scrofula

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Gabapentin and pregabalin/Lyrica are both used to prevent seizures, although I don't think they're particularly good for that (more for nerve pain).

The problem isn't so much taking them at the same time as it is coming off the gabapentin while high on coke (or any stimulant). If you regularly took real high doses of gabapentin, and went cold turkey, you'd have a higher risk of a seizure just doing nothing. Not booze- or benzo- WD risk, but higher than if you'd never used gabapentin before. What you really don't want is to go into slight withdrawal from seizure medication right as you start a big stim session.

And, there's the usual upper/downer problems, where one masks the overdose of the other--it's great until one wears off and then you really feel the overdose, by like dying (potentially).

Personally, I mix gabapentin and meth, often and enthusiastically. There's a weird harmony there. Just, don't stop a regular dosing, go very carefully otherwise; the stuff does take like four coke redoses to kick in anyway.
 

RandomClean3

Bluelighter
Joined
Feb 3, 2017
Messages
85
Ok, let's introduce metabolism.
Methadone: Rule of thumb, do not take if you're taking antidepressants. This is how the son of Anna Nichole Smith died. He stole a recreational but nowhere near deadly amountof methadone from his mom. He was taking sertraline and escitalopram. It's estimated that the inhibition of CYP2D6 dropped methadone's cleareance to half and extended it's half-life by 100%, effectively causing the effect as if he had taken 4 times the dose he took. Bupropion, Fluoxetine, Fuvoxamine, Paroxetine, Duloxetine, Citalopram, Escitalopram, Sertraline, Tricyclics, if you're on any of these or another anti-depressant double check if you can take methadone

Kratom: There is this presumption Kratom is safe, it's not. Granted, it's harder to OD on it than regular opioids, but you can still OD on it. SPECIALLY if you combine it with well, anything. There's not enough data. There have been cases of deaths purely due to Kratom, but the majority involve others drugs. One case was propylhexedrine, others drugs that have been involved in Kratom deaths include alcohol, venlafaxine, mirtazapine, diphenidramine, zoplicone, citalopram, lamotrigine, etc. We know very little about this drug, it has a structure that's very versatile and it's shared by yohimbe, ibogaine, reserpine, basically all pharmacological groups, and it's likely there's more to it than a simple opioid agonist.Mitragynine is metabolized in humans via phase I and phase II mechanisms with the resulting metabolites excreted in urine. In in vitro experiments, kratom extracts inhibited CYP3A4, CYP2D6, and CYP1A2, which may help explain the combined drug toxicity. Basically, if you take kratom, take it with respect and avoid mixing it with pharmaceuticals, or at least check first.

PMA, PMMA and 4-MTA: This are found in bad XTC pills, they're MAO inhibitors. They are known to kill people, specially when the dealer thought it was a good idea to add it to MDMA/MDA. Test your pills, if any of these pop up flush the pills and narc on that bastard dealer.

PDE5 inhibitors (Viagra, Cialis, Levitra) when combined with an NO donor like nitroglycerin, isosorbide dinitrate, nitrous oxide, amyl/butyl/methyl nitrates (poppers) can induce deadly hypotension very quickly, never take these 2 groups of drugs together.
 

RandomClean3

Bluelighter
Joined
Feb 3, 2017
Messages
85
Seizure meds are really complicated, specially the older ones. Phenitoin, carbamazepine, valproic acid, phenobarbital, primidone, all of those induce/inhibit a number of CYP450 isoenzymes, and are very susceptible to being induced/inhibited as well. I would change the rule to don't take coke or any strong upper if you have epilepsy or a mood disorder. Coke is a very dirty drug, triple reuptake inhibitor, sodium channel blocker, sigma agonist, 5-HTC agonist, basically many ways to induce a seizure. But given you take it for neuropathic pain and gabapentin is cleaner than other anti-seizure meds, I think you're fine.
 

phuckingnutz

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Mar 11, 2014
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Inside your head....
I only read the first page and a few other posts, but Alcohol/APAP was not mentioned. Wouldn't that be a dangerous mix.
Like I said, maybe I missed it, but it only listed "CNS depressants/alcohol" on the first page.
 
Last edited:

phuckingnutz

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Inside your head....
Kratom: There is this presumption Kratom is safe, it's not. Granted, it's harder to OD on it than regular opioids, but you can still OD on it. SPECIALLY if you combine it with well, anything. There's not enough data. There have been cases of deaths purely due to Kratom, but the majority involve others drugs. One case was propylhexedrine, others drugs that have been involved in Kratom deaths include alcohol, venlafaxine, mirtazapine, diphenidramine, zoplicone, citalopram, lamotrigine, etc. We know very little about this drug, it has a structure that's very versatile and it's shared by yohimbe, ibogaine, reserpine, basically all pharmacological groups, and it's likely there's more to it than a simple opioid agonist.Mitragynine is metabolized in humans via phase I and phase II mechanisms with the resulting metabolites excreted in urine. In in vitro experiments, kratom extracts inhibited CYP3A4, CYP2D6, and CYP1A2, which may help explain the combined drug toxicity. Basically, if you take kratom, take it with respect and avoid mixing it with pharmaceuticals, or at least check first.

I beg to differ on the Kratom alone causing death. Have you taken much Kratom? Those "reports" of Kratom killing people are basicall Big Pharma BS, IMO. Yeah, you can mix enough other shit WITH Kratom to kill you, but I defy you to take enough on it's own. I have taken Kratom for years and have tried large doses and all you get from large doses is sick.
 

Jabberwocky

Frumious Bandersnatch
Joined
Nov 3, 1999
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45,661
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Looking-Glass Land
I doubt kratom alone would be able to kill someone unless they had some pre-existing health issue. One would get super sick and unable to keep taking it before death would happen. But that is a kind of OD.

With other drugs kratom can definitely lead to death, especially when used longer term at high doses. But it isn’t kratom that kills someone here per se, it’s the poly drug use that is the issue.
 

Jekyl Anhydride

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Jul 23, 2016
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In a xenon pit
Maybe not deadly but how kpins and weed combo?

I would bet there's plenty of sedation but nothing life threatening, like Hypoxia when opioids are thrown into the mix with clonazepam. Cannabis is more about acetylcholine inhibition. Though some of the real Heavy indica edibles might have you in a 14 hour zombie like state if mixed with copious amounts of clonazepam.
 

Chronicpain54

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Feb 21, 2018
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294
I would bet there's plenty of sedation but nothing life threatening, like Hypoxia when opioids are thrown into the mix with clonazepam. Cannabis is more about acetylcholine inhibition. Though some of the real Heavy indica edibles might have you in a 14 hour zombie like state if mixed with copious amounts of clonazepam.

I take klonopin daily, up to 2 mgs , prescribed by my doctor. In the evening I take 1 mg of klonopin and smoke some weed if I have it. The only noticeable side effect for me is basically falling asleep when I don't want to. I'll try to watch my favorite show and next thing I know it's 4 hours later and my legs or arms are asleep from being in a weird position.

Now, my dose of klonopin is small so I don't know if taking 5 or 6 mgs would make a difference. I've been on this dose for a long time and still fall asleep, but then I'm prescribed opioids that I take around the same time, along with 600 mgs of gabapentin.
 

Jekyl Anhydride

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^ That combination might be risky in a polydrug naive person, but you having a tolerance probably increases the therapeutic efficacy of all three/ four meds through synergism. I would think the cannabis is just enough to push the sedation into the Nod phase when the opioids hit at the same time. While the gabapentin is active at the VDCC, voltage dependent calcium channels, it increases GABA through milder downstream effects vs a direct benzo binding site like the clonazepam.

It's a shame GP has such quickly rising tachyphylaxis, when I run out of it for a couple weeks then use it again it really shines. I think you would find stronger resistance from your doctors to prescribe opioids if you were also using 5-6 mg of clonazepam P/D, as that's at the upper limit.
 
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