Warning to wellbutrin XR users
Do not take psychedelics while using wellbutrin.
Cannabis
Mushrooms
LSD
Ketamine
Misc designer psychedelics and dissociatives
All have grossly augmented effects leading to a very unpleasant experience (best case scenario). WB and Ketamine in particular nearly killed me and using the above suvstances in low doses led to a very unpleasant and dirty experience
I appreciate what you're saying, and am sorry you experienced those effects, but I have to forcefully disagree with the idea that all users of bupropion experience this.
I've been taking bupropion (brand name Wellbutrin) for three or four years; started on 150mg XR/day and moved up to 300mg XR a few months after. I'm also on citalopram, at 40mg/day.
I've have never had any problems using ketamine and the aforementioned bupropion. I used to use a lot of ketamine via IM injection, and found the effects inseparable from the effects of ketamine before I began taking bupropion.
Additionally, I'm an on/off cannabis smoker (2 months on, 1 month off for tolerance's sake), and have been since 2014, and bupropion has never resulted in any undesirable effects. I also use psychedelics. I also use research chemicals.
Use the same caution one should always use with drugs; start with an allergy test and then titrate up. If something is going to mix poorly with the bupropion, you'll likely know it before exceeding the threshold dose of x drug.
I will give you this; if you're **just starting** a course of treatment using bupropion (Wellbutrin), I would be careful mixing it with stimulants and psychedelics, due to risk of high BP for the former and an anxiety attack for the latter. Bupropion, in the short-term, can increase agitation/aggression, like many stimulants. Mixing stimulants is usually a bad idea.
But I feel obligated to refute any assertion that taking bupropion precludes, say, smoking cannabis. Be thoughtful and informed when taking stimulants with ALL the drugs you mentioned, because those drugs can mix unpredictably. But don't pin it all on poor bupropion, and scare someone into avoiding psychedelics that can potentially help their mental illness!
(As well, it is worth noting perhaps the most important common interaction you'll find mixing bupropion and drugs: alcohol. Acute alcohol tolerance can be lowered significantly during the early days of a course of bupropion treatment.)
Whenever mixing *any* two substances, be careful, start small, titrate slowly, and be aware of possible interactions. But unless there's science to backup your statement, I disagree with scaring people without evidence, and feel obligated to offer a counter-opinion.