I DO NOT RECOMMEND ANYONE TRY THE COMBINATION I TOOK FOR ANY REASON AND IT IS STUPID TO DO SO!!
Now that that's out of the way....to the info!!! To begin, i am prescribed all 3 of the meds i will discuss, and aside from the Tizanadine (Zanaflex) which I've only gotten for the past 4-5 months(RXd 2mg, thrice/day) i have taken the Roxicodone and Clonazepam for over 5 years and have built up a nice tolerance. I also am very comfortable with how each of these drugs effects me on it's own and mixed with other drugs at various dosages. (Basically, i have had plenty of time and supply to SAFELY try different scenarios over time...)
Last week, around 4:00pm, I personally took 10mg Tizanadine, ~40-50mg Roxicodone AND 4mg Clonazepam at the same time aware of how the 3 meds would be staggered as they hit me due to how fast/slow they take effect (in order for me PERSONALLY, 1st-3rd::: 1st: Oxycodone, ~30 minutes. 2nd: Tizanadine, ~45-60 minutes. 3rd: Klonopin, ~70-90 minutes.) and also made sure my GF would be staying the entire night incase of any breathing issues that could arise. This is very important, all 3 of these medicines can retard your breathing and heart rate!!!! As stated i have a high tolerance to these medications and didn't expect to be knocked out or blown away by anything, but i was surprised by a nice mild opioid euphoria at the start, and when that barely began to fade the relaxation and sedation of the Tizanadine began which combined with the benzodiazepine `feel` about an hour later and that was enough for me to be satisfied until I fell asleep around 1:30-2:00am.
I have noticed any dose of Tizanadine larger than 8mg (even by itself) will give me the feeling of being drunk, but only when I attempted to talk, walk, interact with the world in any way other than simply watch TV. That's what i have noticed with these, please be safe and please stay alive!!!