N&PD Moderators: Skorpio | thegreenhand
You mean the various R2/R3 subs such as LSZ, MIPLA, LSP, LSB, ECPLA, ....?The thing is, the same is true for other psychedelics. Still, the reason for it could totally be related. LSD does have that weird functional group that flips closed like a lid locks it into the receptor.
The latter at least could be easily tested by IVing LSD analogs that lack that functional group and comparing onset times
The latter at least could be easily tested by IVing LSD analogs that lack that functional group and comparing onset times
You mean the various R2/R3 subs such as LSZ, MIPLA, LSP, LSB, ECPLA, ....?
You mean the various R2/R3 subs such as LSZ, MIPLA, LSP, LSB, ECPLA,
Watching now.I'm at work, so I can't check at the moment, but I believe Nichols tackles this around minute 19 or 20 of this video. https://m.youtube.com/watch?v=TxjCSKMbZBA
Doesn't that kill the potency making it pointless?"LSD analogs that lack that functional group" is basically what plain old N,N-dialkyltryptamines are.
2,4-Dimethylazetitidide, N,N-methylisopropylamide, 3-pentylamide, 2-butylamide, and N,N-ethylcypropropylamide are all just bioisosteres for LSD's diethylamide moiety, though.