Hi. I'm on the lookout for a 5ht2b antagonist that does not cross the blood brain barrier. I believe this could be the key to using serotonergic drugs without causing heart valve overproliferation over time. Does anyone know of anything? Also, any comments about psychedelics with low 5ht2b agonism would be great. I recently learned that 25i-NBOME might have a low affinity for 5ht2b, and at the dosage level of 1mg or less, this could mean it has almost no adverse effects on heart valves even with heavy use. All comments, even those that do not directly relate to these questions, are welcome and appreciated.