Absolutely. Most drugs will only be positive for so long once you're addicted to them. I started using opiates and I was happy at the time (relatively anyway), I just wanted to experiment. After many years being addicted to them the very best I could ever hope for was to feel not suicidally depressed, when I was high. I mean really I wasn't even "high" anymore, I just didn't feel like human garbage. The longer it went on, the worse it got. Eventually I quit, 5 years ago, and although it took some work, I recovered and haven't touched opiates since, and my life is infinitely better because of it. Of course I still get depressed and anxious sometimes, but my baseline state is back to being content and happy. I did realize something I was using opiates to cover up though, in the process of quitting them, so when I quit I had to also change those circumstances in my life, otherwise I would probably still be depressed. But being dependent on opiates for so long threw my body and mind so out of whack that I could only feel horrible, or nothingness.