Bravoncius Roxford
Bluelighter
- Joined
- Feb 1, 2017
- Messages
- 105
Forskolin is a molecule extracted from the roots of the Indian plant, Coleus Forskoli. It is a highly potent stimulator of adenylate cyclase, and is used clinically for this purpose. The increase in adenylate cyclase increased intracellular levels of cyclic adenosine monophosphate, which is turn increases the phosphorylation of several proteins, including tyrosine hydroxylase, which is the rate-limiting enzyme in dopamine synthesis. See here: https://www.google.com/url?sa=t&rct...bmed/9137913&usg=AOvVaw0cQVS-NJwyRgttquhPUTXP
Unfortunately, increasing TH with forskolin is not a good strategy, as forskolin induces increased phosphorylation of several other proteins, including the Tau proteins that are implicated in Alzheimer's disease. See here: https://www.google.com/url?sa=t&rct...med/27995573&usg=AOvVaw2TY-Sqj7lb-2CZZ6X1lpMy
When will we get a selective TH inducer that does have these side effects? The only one I am aware of is Panaxatriol from Ginseng, but it is weak and like so many polyphenols, the oral bioavailability is so incredibly shitty that it is not worth the time or money.
Unfortunately, increasing TH with forskolin is not a good strategy, as forskolin induces increased phosphorylation of several other proteins, including the Tau proteins that are implicated in Alzheimer's disease. See here: https://www.google.com/url?sa=t&rct...med/27995573&usg=AOvVaw2TY-Sqj7lb-2CZZ6X1lpMy
When will we get a selective TH inducer that does have these side effects? The only one I am aware of is Panaxatriol from Ginseng, but it is weak and like so many polyphenols, the oral bioavailability is so incredibly shitty that it is not worth the time or money.