dopamimetic
Bluelighter
- Joined
- Mar 21, 2013
- Messages
- 2,065
Has been discussed before, I know, but the topics are archived and unfortunately they don't even load at the moment.
So yeah, my tolerance is sky high - I've gone through half a g of MXE (of doubtable purity though) with just getting a mild mellow feeling, but also the same with 2-FDCK, and months ago with O-PCM where I was on the point of taking probably one gram a day without holing ... Had a break of some months in-between but I just can't hold it for much longer. NMDA antagonists are everything I ever wanted from drugs and some more, they are like a miracle cure for my depression, anxiety, social awkwardness and all, while making me not even looking intoxicated when used below certain thresholds ...
Just now that unholy tolerance. A buddy has an even higher tolerance, she shocked me recently by telling me that she's on more than 1g of DXM while looking / acting completely sober..
Two questions. One - Is it just about the price, and using safe substances and ROA, or will whatever mechanisms of tolerance come into play here, be it NMDA receptors upregulating or enzymes becoming super-efficient in munching the molecules, eventually lead to serious health issues? Guess the enzymes won't hurt but much too many of these NMDA thingies might.
Two - anything serious that one can do to curb that tolerance down, besides from just abstinence for a bloody long period of time? NMDA weak partial agonists or anything else from the experimental side of your knowledge is welcome.
So yeah, my tolerance is sky high - I've gone through half a g of MXE (of doubtable purity though) with just getting a mild mellow feeling, but also the same with 2-FDCK, and months ago with O-PCM where I was on the point of taking probably one gram a day without holing ... Had a break of some months in-between but I just can't hold it for much longer. NMDA antagonists are everything I ever wanted from drugs and some more, they are like a miracle cure for my depression, anxiety, social awkwardness and all, while making me not even looking intoxicated when used below certain thresholds ...
Just now that unholy tolerance. A buddy has an even higher tolerance, she shocked me recently by telling me that she's on more than 1g of DXM while looking / acting completely sober..
Two questions. One - Is it just about the price, and using safe substances and ROA, or will whatever mechanisms of tolerance come into play here, be it NMDA receptors upregulating or enzymes becoming super-efficient in munching the molecules, eventually lead to serious health issues? Guess the enzymes won't hurt but much too many of these NMDA thingies might.
Two - anything serious that one can do to curb that tolerance down, besides from just abstinence for a bloody long period of time? NMDA weak partial agonists or anything else from the experimental side of your knowledge is welcome.