Anyone who has seen pinene dripped onto I2 will see that that that I2 adds to the alkene pretty readily. Now the Russian 'Expert Samples' of krokodil show that some variations of the route yield more methyldesorphine than desorphine (and I'm pretty sure it's because I2 in CH3OH is a common source of I2. What I cannot figure is why the I2 doesn't add to the alkene of methyldesorphine yielding 6-methyl-6-deoxydihydromorphine. The beta epimer of that latter compound is some x60 M (but who knows how potent the alpha is).
All I can suggest is that the P has all been oxidized to H3PO3/H3PO4 yielding I2 so that there is little to no free halogen in the reaction. I know the 'cooks' use the colour to detect completion (which only means all the I2 is used, I presume) thus no I2 to add OR the Russian 'expert samples' aren't too expert. The toxicology team at the University of Porto are checking for the presence of WP and for P containing species derived from the codeine (because several impurities with MW 340-469 show up in GC-MS).
I'm asking if others agree that the alkene SHOULD add because I don't think it will add to the allylic group but should add across the 6,7 or 7,8 double-bond in desoxymorphine C/D which explains why no unsaturated constituents are found. If it COULD add to the allylic moiety, plain I2 in CH3OH added before the RP might prevent the formation of the P containing derivatives.
This isn't a case of making a 'how to' guide but Portugal leads the world in HR so I CAN discuss these things with the people at Porto uni. They are keen on new ideas and are very approachable so anyone with insights into the various toxic species would do well to communicate those ideas.
All I can suggest is that the P has all been oxidized to H3PO3/H3PO4 yielding I2 so that there is little to no free halogen in the reaction. I know the 'cooks' use the colour to detect completion (which only means all the I2 is used, I presume) thus no I2 to add OR the Russian 'expert samples' aren't too expert. The toxicology team at the University of Porto are checking for the presence of WP and for P containing species derived from the codeine (because several impurities with MW 340-469 show up in GC-MS).
I'm asking if others agree that the alkene SHOULD add because I don't think it will add to the allylic group but should add across the 6,7 or 7,8 double-bond in desoxymorphine C/D which explains why no unsaturated constituents are found. If it COULD add to the allylic moiety, plain I2 in CH3OH added before the RP might prevent the formation of the P containing derivatives.
This isn't a case of making a 'how to' guide but Portugal leads the world in HR so I CAN discuss these things with the people at Porto uni. They are keen on new ideas and are very approachable so anyone with insights into the various toxic species would do well to communicate those ideas.