Misc How can we know if there will be any long term effects to agomelatine or not?

[Deioflaje]

It has only been used for about 10 years now so how do we know if there won't be negative effects down the line?

I looked up and they said it isn't genotoxic just hepatotoxic.

Does that mean there shouldn't be much else to worry about?

Who know if it fucks your melotonin down the line or something like that?

I would like to try it though since otherwise it sound very interesting in terms of lack of side effects and otherwise a profile I would be interested in.

I suppose it's just a case of weigh up the risks/potential benefits and shit or get off the pot.

 

[tacodude]

I think hepatoxic damages the organs like the liver.

 

[d1nach]

Im confused why wiki places alot of emphasis on its 5-ht2c antagonism but lists its value at 631 nM vs drugs like olanzapine 1-24 nM.

If the antidepressant effect is totally based on the melatonin receptor

How does the metalonin 1 and melatonin 2 cause antidepressant affects?

I dont know enough to try it personally while interesting