N&PD Moderators: Skorpio | thegreenhand
Is there any way to put that furanyl thing in the place of n-methyl in morphine? I think an n-phenethyl substituted version was 14x more active than morphine, so much the same SAR as with the piperidines.
Probably more healthy than krokodil...
I'm not entirely clear about the legal situation of deoxymorphine-D (compound 1) in light of someone seemingly trying to go for that product. It seems to me that making it harder to extract the codeine from the generic co-codaprin or co-brufen is the simplest move.
Don't forget that codeine is itself a class B drug and thousands of empty packets is a bit of a give away and involving the kind of people who will go into smurfing is more or less ensuring that you will be spotted.
If someone were to convert the morphine/codeine into something a lot more potent, such as first converting it to desomorphine/oxymorphone and then putting something better in the place of the N-methyl, a very large amount of the precursor wouldn't be needed. Enough could be obtained even by extracting from unwashed poppy seeds. Probably easier than obtaining the phenethylamine, ethyl acrylate, sodium metal, etc. for fentanyl synthesis.
Edit: LC, the other ingredients in the codeine cough preparation will probably not make it difficult to extract the codeine if you have proper equipment, but it will make it more problematic for an amateur who's used to only extracting DXM and eyeballing a few grains of solid lye to add to the DXM medication. Also, I think the presence of the alkene double bond in codeine makes it more prone to be attacked by an overly alkaline solution than DXM is.
No - illicit fentanyl is almost entirely made via the 'Seigfried Method' (DEA Microgram) so it's just 2 steps (plus workup). The precursors are items of commerce. Codeine is not a good starting material for potent phenanthracine opioids although several [POM]s are but even if you have them, it's a LOT of work. I mean a LOT. Yields and mechanical losses make it a pointless exercise. Desomorphine is about as far as it's feasible to go but that's quite far enough to pose a real threat and scaling that means smurfing thus a bunch of muppets WILL know or guess at what you are doing and will happily turn you in next time they are copped with a ?10 bag.
That said, who the fuck wants to work with etorphine? and of them, who will survive it? and of their customers, who will survive more than a single dose.
OT people are aware of the commonality of the butyrophenone/diphenylbutylpiperidine neuroleptics and opioids? Janssen used the same scaffolds to find the QSAR of both.
SAR not QSAR