I've been desperately wanting to try desomorphine-D, almost got there too, but I decided to try the intermediate alpha-chloromorphide though and it was just SO peculiar and not opiate-like that I couldn't help BUT to try bioassay of the stuff, and it got into too much of an interesting project that I never got to final reduction to desomorphine. But...it'll happen alright. Its one of my top opioids, along with dipipanone, ketobemidone and levorphanol.
NOT 'krokodil', mind you in the case of desomorphine, but catalytic hydrogenation of the chloromorphide intermediate to desomorphine-D, rather than any nasty-ass Nagai reduction of chlorocodides etc. and certainly no russki peasant-style synthesis of it and injecting iodinated, solvent-soaked, phosphorus-containing nasty ass mixtures of obscene shit. Something that'll be purified and recrystallized, tested via chromatography etc. before ever going into me, but the drug itself, as it should be. Fuck yes, do I ever want to try the proper desomorphines in the clean state. No Nagai HI/red phosphorus reduction of chlorocodide, but nice, clean, environmentally friendly, selective reduction of the intermediate via various types of catalytic hydrogenation and if needs be, chromatography to ensure purification, and indeed selecting out other desomorphines so that each, and modifications of each can be tried separately.
(and of course, unlike desperate russian peasant junkies, I of course have both the equipment and knowledge to carefully separate out the different types of desomorphines, and most CERTAINLY would not ever, ever just shoot up a slurry of iodinated, iodine-contaminated, phosphorus-in-lighter fluid toxic, acidic slop. Nor would I be in the very tiniest degree satisfied with either an impure mixture when it comes to administration, or for that matter multiple-component otherwise clean mixtures of various different desomorphine-type compounds, since merely 'extreme euphoric rush on IV injection' in a mixture of similar ppioids isn't good enough or anywhere close. I want to try each possible one, on its own, so I can broaden my experience overall, and test each drug individually.
Also oxylove, the pressurized reaction with HBr/dihydrocodeine WON'T give desomorphine, but rather would give dihydromorphine. I've never had any of the desomorphines, not yet. Got as far as alpha-chloromorphide, but got distracted since there is VERY very little in-vivo data on it, even in mice or rats. So decided to guinea-pig it, and the alpha-chloromorphide got used before any could be subjected to catalytic hydrogenation using Pd/BaSO4 etc. So, some more will have to be...made available...at some point and the reduction step followed through by those kind, and quite madly generous chemists who seem to want to use LC as a tester for so many things...before he gets to try desomorphine-D and desomorphine-C etc. He's been meaning to let them know, and likewise, to tell them he's interested in desocodeine if ever said selfless people decide that desocodeine and analogs of it are on their to-do list for the day. He has heard that desomorphine-D is worth it certainly, so if they do decide to make any, then they can sign him up without any complaint on his part as a tester
But have had 6-monoacetyldihydromorphine and that, especially since I'd combined with memantine in the same shot. That, was absolutely astonishing in the sheer intensity of, and prolonged nature of the rush itself on IV, the rush itself lasted nearly 3/4 hour, before it began to tail off and the high itself started. Amazing, literally had me staggering and doing my best to hold on to surroundings to prevent my ass from hitting the deck. Unfortunately his...allies? seem to have a distinct shortage of precursors for desomorphine, and LC can hardly spare his pain meds en masse, considering he needs what he has, and is simply saving a small portion of the contents of the morphine. Still, it'll get done eventually, it wasn't as if, at least so he is told, that the formation of alpha-chloromorphide was difficult, and that was without any research papers to guide him. Now he can tell his little drug-gnome friends more useful things such as solubility data, workup guidance etc.
And no, it'd be no 'krokodil', no toxic slops floating in a sea of red phosphorus, iodine, SOCl2 and petroleum spirit, but nice, clean catalytic reduction under H2 using supported low-activity catalytic systems such as Pd on barium sulfate (sulfur, along with lead, are both highly notorious for 'poisoning' precious metal catalysts, lowering their activity, although in many cases most undesirable, there do exist deliberately 'poisoned' supported catalysts of that kind, which are intended from the outset to have such lowered activity, in order to confer upon them, greater chemoselectivity and allow for a finer touch where certain functional groups are present. He's buggered in an entirely new whole SET of assholes, diagonally with a rusty garden rake if he'd ever inject dirty, poisonous muck like russian krokodil.
Those gnomes though, they just need to get together say, 10g-20g of morphine to make a synthesis of that nature viable in terms of not having to fart around with ultramicroscale chemistry, they have always told LC that they hate doing that wherever it is avoidable.
I get you, chemically pure desomorphine is nothing like krokodil, would be awesome to try
