JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,468
So, a neurotransmitter in the synapse binds with a receptor protein on the post synaptic membrane.
Say it's g-protein coupled.
The transduction process I can't list out precisely but, something to the effect of, g-protein activating ion channels, gives rise to kinases activating protein phosphorylation - somewhere in there about transcription factor incorporation into RNA and the resultant biological effects.
However - in the neuropharm books, there were mention of GIRK's by example, ion channels - but it did not seem to stress to what degree the cell hyperpolarization plays a role, or the degree to which it's implicated by the initial post synaptic binding.
I know in the pre-synaptic cell, an action potential generated via binding of transmitter at the dendritic end of the cell, causes the release of the transmitter at the axon terminal.
But in the post synaptic cell?
Cell hyper and depolarization would obviously play a significant role in the flux of ions in and out of the cell, or perhaps the flux of ions determines the cells polarization?
In any case - wouldn't that post synaptic cells polarization, play a significant role in the drug effects?
Obviously - my facts aren't in exact order so - if anyone better versed in this area can clear things up a little here.
Basically - post synaptic cell polarization and how it implicates therapeutic effects of drugs directly?
If that makes sense?
Say it's g-protein coupled.
The transduction process I can't list out precisely but, something to the effect of, g-protein activating ion channels, gives rise to kinases activating protein phosphorylation - somewhere in there about transcription factor incorporation into RNA and the resultant biological effects.
However - in the neuropharm books, there were mention of GIRK's by example, ion channels - but it did not seem to stress to what degree the cell hyperpolarization plays a role, or the degree to which it's implicated by the initial post synaptic binding.
I know in the pre-synaptic cell, an action potential generated via binding of transmitter at the dendritic end of the cell, causes the release of the transmitter at the axon terminal.
But in the post synaptic cell?
Cell hyper and depolarization would obviously play a significant role in the flux of ions in and out of the cell, or perhaps the flux of ions determines the cells polarization?
In any case - wouldn't that post synaptic cells polarization, play a significant role in the drug effects?
Obviously - my facts aren't in exact order so - if anyone better versed in this area can clear things up a little here.
Basically - post synaptic cell polarization and how it implicates therapeutic effects of drugs directly?
If that makes sense?