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What about meth turns people into sexual sleeze balls?

nuttynutskin

Bluelighter
Joined
May 15, 2011
Messages
10,681
Scientifically speaking? As someone who's never done it and never will I've always found it funny people talking about watching the most fucked up porn and jacking off for hours on end. I don't understand how a drug makes you do that. Enlighten me?
 
Dopamine plus energy= very low inhibitions. Trust me it's shit you deep down are curious about. You learn a lot about yourself
 
Doesnt do that to me these days but when I was with aomeobw it did somewhat .

Blokes apparently get limp on it but not in my experience . Mdma did that and it was annoying.
 
I've always thought the crystal dick thing was funny, it definitely never did that for me. Quite the opposite actuallh.
 
This thread'll get locked in BDD as it's clearly not HR ;)

Therefore I can either move to Drug Culture for chat-type feedback, or N&PD for a more scientific response. I'm gonna try the latter and see how it fares over there for you mate.


BDD --> N&PD
 
D4 stimulation, and reduced inhibition combined with plain old D2 stimulation.
 
Based upon preclinical research, meth stimulates D1 type MSNs in the NAcc shell and initiates signaling cascades that progressively increase accumbal DeltaFosB through the same signaling pathways as sexual activity. Accumbal DeltaFosB mediates the bidirectional (i.e., two-way) reward cross-sensitization effect between amphetamine-type stimulants and sexual activity; consequently, high levels of expression of that protein in the NAcc, which normally occurs following chronic high dose use of amph/meth, can induce a hyperactive sex drive following intake of one of those drugs.

D4 stimulation, and reduced inhibition combined with plain old D2 stimulation.
While it's true that some direct dopamine receptor agonists can induce hypersexuality through activation of D2-type receptors, those receptors don't normally mediate that effect of indirect agonists.
 
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^ interesting, thanks.

I've always found that anxiety and potent adrenergic stimulation was required to hit true heights of libido, at least for me personally.
 
It increases sex drive in general. So since being on meth or other stims makes you horny for longer, you get to thinking about stuff you ordinarily wouldn't eventually.
 
Seppi said:
Accumbal DeltaFosB mediates the bidirectional (i.e., two-way) reward cross-sensitization effect between amphetamine-type stimulants and sexual activity; consequently, high levels of expression of that protein in the NAcc, which normally occurs following chronic high dose use of amph/meth, can induce a hyperactive sex drive following intake of one of those drugs.

Does this also mean that after you've been sensitized to amphetamine-type stimulants, sexual arousal will make one crave amphetamine-type stimulant? Does this have something to do with the desire to smoke a cigarette after sex in nicotine/tobacco-dependent people?

In my experience plain amphetamine never really made me sexually aroused or more prone to sexual arousal, it may be quite different with methamphetamine, on the other hand MDMA, mephedrone and similar drugs certainly did. I also found it very interesting that at those times when I felt overly stimulated from empathogens in the way you feel stimulated during fight-or-flight situations, i.e. anxious (could be due to specific response due to set & settings or the drug being contaminated with stimulants such as amphetamine or caffeine), tactile sensations as well as mental pleasure during sex would not be increased as they usually are with MDMA and having sex would not lead to the relief of arousal but rather make me more irritated at the end of it. I'm not sure if it is related to too much adrenergic action or rather generally related to higher anxiety levels. Basically, you need to feel calm and relaxed before having sex to draw real pleasure and bonding with a partner from it, hence if an amphetamine makes you anxious, it certainly won't make you sexually aroused, so I guess people with naturally higher levels of anxiety will experience this effect differently.
 
Does this also mean that after you've been sensitized to amphetamine-type stimulants, sexual arousal will make one crave amphetamine-type stimulant? Does this have something to do with the desire to smoke a cigarette after sex in nicotine/tobacco-dependent people?
In general, yes, although it likely depends upon whether an individual has engaged in amphetamine use and sexual activity with at least some regularity in the past. Cross-sensitization to a stimulus doesn't occur when one hasn't been exposed to the cross-sensitizing stimulus. In other words, you can't experience amplified incentive salience/"wanting" for something you've never experienced before. A simpler way to think about this is that people "learn" an association between amphetamine use and sexual activity as addictive (i.e., drug/natural reward) cues for each other. I believe that the underlying phenomenon that describes this association is specific Pavlovian-instrumental transfer, because this is a classically conditioned association that modifies incentive salience and operant behavior.

The reason people typically engage in sexual activity on a regular basis while on amphetamine-type stimulants in the first place is the same reason people take addictive drugs (pleasure), although in this case the pleasure isn't drug-induced euphoria; rather, it's intensified pleasure from orgasms.

In my experience plain amphetamine never really made me sexually aroused or more prone to sexual arousal, it may be quite different with methamphetamine, on the other hand MDMA, mephedrone and similar drugs certainly did.
It's probably a safe assumption that you've never been addicted to an amphetamine-type stimulant. This cross-sensitization effect is entirely mediated via signaling in the D1-type gabaergic medium spiny neurons in the NAcc shell which the mesolimbic dopamine pathway synapses onto; those neurons are responsible for assigning incentive salience (i.e., "wanting") to rewarding stimuli. Keep in mind that there are at least 6 distinct phenotypic populations of neurons in the NAcc that the mesolimbic pathway synapses onto: D1-type, D2-type, and mixed-type gabergic neurons in the NAcc core and NAcc shell. The D1-type and D2-type neurons in each structural region of the NAcc (i.e., the shell and core) mediate opposite cognitive processes and the NAcc core and NAcc-shell mediate entirely distinct cognitive processes associated with both reward and aversion. There isn't enough research on mixed-type neurons (i.e., gabaergic neurons that express both classes of dopamine receptors) for me to comment on what cognitive processes those mediate in relation to D1-type and D2-type neurons; these mixed-type neurons are mostly confined to the NAcc shell, but there are some in the NAcc core.
 
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It increases sex drive in general. So since being on meth or other stims makes you horny for longer, you get to thinking about stuff you ordinarily wouldn't eventually.
Amphetamine and methamphetamine reduce libido in some individuals. An increased libido occurs more often in men than women.
 
I don't think I've ever met a woman who it didn't kick her sex drive into high gear
 
I don't think I've ever met a woman who it didn't kick her sex drive into high gear

Most people who use methamphetamine use it recreationally; that's probably why you've observed this. :p
I would be surprised if you've observed this phenomenon in a first-time meth user though.
 
I tried to stay away from newbies lol. Burnt dope sucks
 
It just dumps heaps of feel good chemicals into your brain like nothing else, damages it (requiring more than just by tolerance), and conditions itself to be wanted way more than any prescription could.
 
. A simpler way to think about this is that people "learn" an association between amphetamine use and sexual activity as addictive (i.e., drug/natural reward) cues for each other.
The reason people typically engage in sexual activity on a regular basis while on amphetamine-type stimulants in the first place is the same reason people take addictive drugs (pleasure), although in this case the pleasure isn't drug-induced euphoria; rather, it's intensified pleasure from orgasms.


It's probably a safe assumption that you've never been addicted to an amphetamine-type stimulant.

I think that here you are using "addicted" with accuracy/ a precise neurological meaning
I use them (*) but I've never been addicted/craved to an amphetamine-type stimulant .
Sex doesn't make me crave for amphes. Amphes do make me crave for sex... not it is untrue. If under the influence I start to jerk( that is, every time I use), than I can not stop because it is so pleasurable.
I think this is different from the learn/cue thing.

(*) not exactly, expecially mephedrone.
Meth is more straight on to sex and pleasure, with meph there is less push but an indirect effect.
The serotonin/empathogenic side enhance sexual fantasies and make sex ( jerking) better by this way
 
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I think that here you are using "addicted" with accuracy/ a precise neurological meaning
I use them (*) but I've never been addicted/craved to an amphetamine-type stimulant .
Sex doesn't make me crave for amphes. Amphes do make me crave for sex... not it is untrue. If under the influence I start to jerk( that is, every time I use), than I can not stop because it is so pleasurable.
I think this is different from the learn/cue thing.

(*) not exactly, expecially mephedrone.
Meth is more straight on to sex and pleasure, with meph there is less push but an indirect effect.
The serotonin/empathogenic side enhance sexual fantasies and make sex ( jerking) better by this way

You're correct that it's not the result of a cue. That one-way effect on pleasure isn't due to sensitization; it's due to the pharmacological effect of the drug on hedonic hotspots. That does, however, over time result in individual learning to associate the two as a cue for one another. Cross-sensitization of pleasure doesn't occur; cross-sensitization of cognitive reward (i.e., incentive salience) does.
 
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