psynce of sound
Bluelighter
- Joined
- Aug 14, 2014
- Messages
- 386
This is something I've been musing over for a while now. I'd definitely love to gain more concrete information on the possible reality of it.
So would ring constrained ester analogs of the phenidates be a) possible, b) Have any activity or be inactive, c) how would my proposed changes alter the effects on receptors and subjective effects in vivo/vitro?
Right now for the the rings I propose:
Methylenedioxy,
Ethylenedioxy,
Furanyl,
Thiophene.
I understand that these changes won't give the phenidates magical mdxx properties as they're reuptake inhibitors. Though if they aren't inactive due to steric bulk I also wonder if the ring constraint change would allow for further modification?
I'm not sure how relevant further modification would be until the initial modification was understood in it's pharmacological profile changes.
Thank you for your time with this question.
Psynce.
So would ring constrained ester analogs of the phenidates be a) possible, b) Have any activity or be inactive, c) how would my proposed changes alter the effects on receptors and subjective effects in vivo/vitro?
Right now for the the rings I propose:
Methylenedioxy,
Ethylenedioxy,
Furanyl,
Thiophene.
I understand that these changes won't give the phenidates magical mdxx properties as they're reuptake inhibitors. Though if they aren't inactive due to steric bulk I also wonder if the ring constraint change would allow for further modification?
I'm not sure how relevant further modification would be until the initial modification was understood in it's pharmacological profile changes.
Thank you for your time with this question.
Psynce.