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Alpha-Ethyl Psychedelic 'Amphetamines' (Aephetamines)

blueberries

blueberries

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I'm not sure if this has been covered before and they are inactive, but making amp's alpha-methyl into an ethyl, how would that play in regards to DOC or DOM. Sure there would be reduced potency but maybe the trip is a little shorter and/or more relaxed. Maybe a propyl group to put into into the league of 2C's or an iso-propyl group, which could be similar to te ethyl but slightly less potent. Or even double or triple bonded analogues such as alpha-Ethynyl 2C-x.

Would these effect the colour and taste of the trip too or would they behave similarly to the BOx chems (i.e similar to the parent PEA but lighter)

Perhaps if it were paradoxically stronger, maybe a beta-ketone group (possible kiss of death but you never know!) or even di-deuterium would smoothen it out. Christ, I'm jumping the gun a bit here but maybe a beta-fluorine (I love that little halogen!), or even alpha-fluorine.

I just had a look into PIHKAL to find the alpha-ethyl version of Mescaline which turned out to be a dud, but then again that's mescaline, DOx are a totally different ballgame, also Shulgin was under the impression that ethylating it would double the potency, which is far from the truth. I'll do some more digging but let me know your thoughts


EDIT: OK I've just found ARIADNE, nevermind. Hoever the idea of alpha-fluorinated DOx still stands.
 
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The 4C's were tested by some chemists who were published in The Entheogen Review. They were mildly trippy, music enhancing, sounded a bit like MMDA. Visuals were prominent, body load was heavy, mind was fuzzy. This question pops up from time to time. The last time I posted the link, it rotted, so here it is on scribd:

http://www.scribd.com/doc/162945565/entheogen-review-volume-xii-number-3
 
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blueberries said:
***(Read Post Script)***
EDIT: OK I've just found ARIADNE, nevermind. Hoever the idea of alpha-fluorinated DOx still stands.
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What would be the benefit of having a highly electronegative atom on the alpha-carbon? I would guess you would just mangle binding into 5HT receptors and thus reduce potency. Sometimes when you have alkyl-fluorides you get a high degree of reactivity as well, for instance sevoflurane.
 
This is a terrible thread. mindless speculation belongs in the "I like to add a methylenedioxy to everything" thread, no?
 
Haha agreed ^^, I don't even remember writing this, the novelty of midazolam's water solubility is wearing off now, plus I have some lovely mxe to stave the wolves from the door. I'm having this fervered need to put a fluorine on everything I see. It's unhealthy.

Anyhoo, I'm gonna anaesthetise myself sufficiently, break down some layers of my ear drums and fuck about with as many receptors as humanly possible. Outlook is callling.

Kisses.
 
Hammilton said:
This is a terrible thread. mindless speculation belongs in the "I like to add a methylenedioxy to everything" thread, no?
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Yeah, well at least now I know alpha-fluoro psychedelics are a no go! However, yeah, even by my wikipedia lets-build-psychedelics-like-legos standards this is pretty useless thread. However it is useful in the sense you can search up alpha-ethyl psychedelics and this will pop up and teach you that they are not that great of an area.


A question about psychedelic amphetamines and aephetamines: How are they in the field of monoamine-release/inhibition? I find it hard to believe that they wouldn't have any effects like that.
 
Fucking wonderful to see that the alpha-ethyl questions are being raised again, I inquired about these a few years ago and that went no-where, would there be a better way that we can sort this thread out and compile more data about the alpha-ethyl phenethylamines? I hate that they seem to be getting overlooked when there is some pretty compelling evidence to warrant further exploration.

MBDB is a good starting place:

http://en.wikipedia.org/wiki/MBDB

and its buddy:

http://en.wikipedia.org/wiki/Butylone

Jumping from that we can point a finger at buphedrone:

http://en.wikipedia.org/wiki/Buphedrone

But why stop at buphedrone when we can put another one on here:

http://en.wikipedia.org/wiki/M-ALPHA


and here is another oddball, http://en.wikipedia.org/wiki/4-methylphenylisobutylamine



I want to point out that there seems to be this weird interest for things with a beta-ketone group that has been persisting for the past 2-3 years, many people seem fine lapping up any mdpv and its kin, there has been such concentration on pyrovalerone derivatives and the lot from A-PVP to pentedrone, a-PPP,

http://en.wikipedia.org/wiki/Α-PPP

its even going out to long chains with things like PV8. To me it seems pretty crazy to overlook this family so much, I mean just look at all of these substituted cathinones:

http://en.wikipedia.org/wiki/Substituted_cathinone

Seems pretty crazy to me that people are going that far into uncharted waters when there could be more research into alpha-ethyl or alpha-propyl/isopropyl compounds. I would like to see this directed in more of a positive direction than cathinone type compounds, there was a time when the 2C's were insightful and not illegal, maybe something similar to the 4C's is out there and maybe something can be learned from all of these pyrovalerone derivatives that were made.
 
For the cathinones extending the alpha chain gives a valuable increase in lipophilicity which aids crossing of the BBB.

For amphetamines this is not necessary and so a-chain extension makes a worse ligand without increasing potency by BBB penetration enhancement.

Something to bear in mind.
 
Thank you for that input Transform, I am a bit of a busy person and these topics have my interests but I don't have the time to research things as much as I used to, I still like to prod the fire when I am able and think it is always an important thing to do, what would changing the beta-ketone to a methoxy or sulfoxide do in such instances?
 
I know enough about BOD (and am anxiously waiting for it and BOB and BOC to make their way to the front of current research trends), my poorly worded question is weather there is a possibility for something interesting to come out of alpha chain length increases with such a compound. BOD with an alpha-methyl would seem to have potential interest but I would think many more would want alpha-BOB, seems to me that things may be getting overlooked and I am just wanting to see what kind of things can be made, what effect with increasing the alpha-chain on a beta-methoxy be in such cases as were discussed above?


Edited to add more fun to the table:

And to go off into a similar related idea, how about we play with a ritalin a bit and see what can be said there, sorry to keep picking your brain but I would love to see new ideas come to fruition if possible.

http://www.chemsynthesis.com/base/chemical-structure-21380.html

Methyl 3-amino-2-phenylpropanoate

good starting point for a few different directions, why haven't I thought about this before as a starting point?

Here is what someone may tell me is an implausible stimulant between amphetamine and methylphinidate

Methyl 3-amino-2-phenylbutanoate


I would much rather see this backbone be used for phenethylamines, someone please tell me I am on to something or tell me why I am not.
 
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Is there any specific risk of thiones ending up as nasty irreversible agents, enzyme ligands one wouldn't wish to encounter, etc?

Aside of course, from the potential for one almighty blinder of a stygian reek.
 
blowjay said:
I know enough about BOD (and am anxiously waiting for it and BOB and BOC to make their way to the front of current research trends), my poorly worded question is weather there is a possibility for something interesting to come out of alpha chain length increases with such a compound. BOD with an alpha-methyl would seem to have potential interest but I would think many more would want alpha-BOB, seems to me that things may be getting overlooked and I am just wanting to see what kind of things can be made, what effect with increasing the alpha-chain on a beta-methoxy be in such cases as were discussed above?


Edited to add more fun to the table:

And to go off into a similar related idea, how about we play with a ritalin a bit and see what can be said there, sorry to keep picking your brain but I would love to see new ideas come to fruition if possible.

http://www.chemsynthesis.com/base/chemical-structure-21380.html

Methyl 3-amino-2-phenylpropanoate

good starting point for a few different directions, why haven't I thought about this before as a starting point?

Here is what someone may tell me is an implausible stimulant between amphetamine and methylphinidate

Methyl 3-amino-2-phenylbutanoate


I would much rather see this backbone be used for phenethylamines, someone please tell me I am on to something or tell me why I am not.
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Nice thoughts, BJ. Will add more when I get a sec!
 
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