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Hey I thought the grey matter of ADD could chew on this....

neversickanymore

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What do you guys think of this.. sound, somewhat sound, millarky.. whats bs whats not.. what would you add to a list of beneficial supplements/medications to promote Neuroregeneration or increased stimulation of Neuroplasticity? Thanks for any/all opinions and effort.

Therefore one part of recovery from heroin use is to regenerate the brain. You need to restore balance and function to the brain. Orthomolecular medicine uses only natural substances that are safe and non-toxic in a wide range of dose and mainly uses herbs, vitamins, and minerals. This was developed as an orthomolecular protocol to improve the brain of heroin users.

Vitamin B-5 500mg to 1 gram per day - vitamin B-5 is the vitamin that is needed to metabolize and breakdown substances in the brain. In other words you need enough vitamin B-5 for the brain to work optimally. According to Dr. Bob, usually vitamin B-5 in brain metabolism needs about a 1-3 ratio to other brain substances such as choline, L-phenylalanine, and others to properly effect the necessary chemical reactions in the brain. This is why Dr. Bob recommended one-half to one gram per day.

L-phenylalanine 250mg per day – L-phenylalanine is an essential amino acid that is a precursor to two key neurotransmitters (chemical messengers of the brain) that promote alertness: dopamine and norepinephrine. The effects of improving dopamine and norepinephrine can lead to elevated mood, aid in memory and learning, and decrease pain. It is often used in orthomolecular medicine to treat depression. Supplemental L-phenylalanine should not be taken by pregnant women or by people who suffer from anxiety attacks, diabetes, high blood pressure, phenylketonuria (PKU), or preexisting pigmented melanoma, a type of skin cancer and multiple sclerosis.

Tyrosine 500mg per day - tyrosine is another precursor of the neurotransmitters norepinephrine and dopamine, which regulate mood, among other things. A deficiency of norepinephrine in the brain can result in depression. It also is involved in the metabolism of L-phenylalanine. Supplements of L-tyrosine should be taken at bedtime or with a high carbohydrate meal so that it does not have to compete for absorption with other amino acids. Persons taking monoamine oxidase (MAO) inhibitors often prescribed for depression should not take any supplements containing L-tyrosine, as it may lead to a sudden and dangerous rise in blood pressure. Persons with multiple sclerosis should not use supplemental tyrosine.

Citicholine 250mg per day, also called CDP-Choline - citicholine is metabolized in the brain to produce the neurotransmitter acetylcholine. Acetylcholine is involved with memory, thought, sexual function and many other vital aspects of functioning. Improving acetylcholine levels is an aid in regenerating a heroin user's brain. Citicholine also has been shown to be involved in producing other neurotransmitters of the brain. Take it in conjunction with vitamin B-5 supplementation.

L-pyroglutamate 800-1000mg per day - enhances acetylcholine function because it boosts the metabolism of the neurons that manufacture acetylcholine. It also improves acetylcholine by increasing the number of cholinergic receptors in the brain. The cholinergic system is the primary conduit of thought and memory that mainly employs the neurotransmitter acetylcholine.

Acetyl-L-carnitine 1 gram per day - is an important antioxidant of the brain and is involved in many aspects of neuronal metabolism. Antioxidants neutralize free radicals and damage from heroin use to brain tissue results in the accumulation of free radicals. Heroin use also makes it vital to stimulate neuronal metabolism, the ability to produce energy for the chemical reactions necessary for the brain to work.

Deprenyl - is a prescription substance that is capable of protecting the important neurotransmitter dopamine. Low levels of dopamine can impair cognitive function. Inform the doctor of any other supplements you are taking in conjunction with deprenyl, since all of the substances mentioned in this protocol create synergy and make each more potent. In other words all of these substances in this protocol help each other work better and therefore the doctor will need to determine your deprenyl dose, which may be more or less the usual dose recommended.

Melatonin 1-3 grams at bedtime - the main antioxidant of the brain, it helps to repair and protect the brain from damage. We mentioned that heroin use leads to accumulation of free radicals from prior damage and ongoing damage. Melatonin helps to neutralize and repair this damage.

Hydergine Sandoz - this is a prescription substance that increases oxygen in the brain tissue. Increasing oxygen in brain tissue can greatly improve the brain of a heroin user. We mentioned that damage to the brain can lead to decreased circulation. The decreased circulation reduces the levels of oxygen that can get to brain tissue. Hydergine can improve this condition. Hydergine acts in synergy with most of the nutritional supplements in this article. You therefore need a doctor who is familiar with hydergine and will know what dose to start you off at and what dose to build you up to. Inform your doctor of the other supplements you are taking when you ask about Hydergine.


Thanks again for checking it out.
 
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Worth Taking
Vitamin B-5 (aka pantothenic acid)- you do need it, but not 500mg a day! - RDA is about 5-8mg/day. More will probably just end up in your urine.
Citicholine - Positive neuroprotective effects, cannot hurt to take it at 500mg-2000mg/day.
ALCAR (acetyl-L-carintine) - water soluble antioxidant. Can't hurt to take it.
Melatonin - uh, try 0.1 to 3 mg at night for sleep. More can have negative effects on horomones and sleep cycles.

Probably Not
L-phenylalanine, tyrosine - These are dietary amino acids. There is no harm in trying them, but a more cost effective source is protien-rich foods.
L-pyroglutamate - dehydrated form of L-glutamic acid. No major evidence that it has any beneficial effects.

Talk to your dr about these 2:
Deperenyl - this is aka selegiline, it is a fairly selective MAO-B inhibitor. Contraindicated with the use of some psychotropics, but generally has a tolerable side effects profile.
Hydergine/ergoloid - This is a drug with a very broad, vague spectrum of action but does also have benefits of its own.

Other good ideas:

Vitamin C - water soluble antioxidant.
alpha lipoic acid - fat soluble antioxidant.
vitamin E - fat soluble antioxidant.
Coenzyme Q-10 - fat soluble antioxidant.
Regular excercise and a helthy diet
 
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Is it okay to take Deprenyl and hydergine? I thought it exerted it's vascular effects through a serotonergic mechanism, doesn't it? Gotta get to sleep, but deprenyl is a very good drug if you know what you're getting into.
 
Avoid that "nootropic" garbage. MAO-B slelective inhibitors are fairly safe but really you're screwing with a system that's already damaged in addiction, excessive DA receptor stimulation is more likely to cause severe compulsive behaviour than anyone seems to think.
Also, for the hydergine it's got a LOT of potential issues with pulmonary and cardiac fibrosis. Not so much of an issue if you're 80 and have dementia, but it definitely causes some issues with long term use.

Pretty much fish oils, a good diet, a multivitamin, and well known BBB permeable antioxidants are the things to look.
 
The racetams are garbage? I took piracetam for two months and noted improved cognition and depression. Just curious.

So fish oil, (B)MAOIs, vitamins, etc. and no amphetamine?

^off topic: What was that enzyme (I think) that is most ideal for neutralizing what you showed as potential amphetamine neurotoxicity?
 
I thought it was curcumin (from tumeric) that EA was big on.

Lol how could I forget! Curcumin has a lot of promise if you can get past it's abysmal bioavailability (read: expensive propitiory formulations). I did the math and it turns out that the doses people were doing for the amphetamine tolerance trial runs were generally way too low. You need like 2-3g a day if its not in a more bioavailable formulation.
 
How much tumeric would one have to eat to achieve a good loading of curcumin?

Well at ~5% curcumin in the raw spice, way too much. I've seen reports of long term consumption of ~200mg a day from curry being common in India though, and that leads to significant plasma levels.
 
Nootropics seem to be a bit like steroids, in that unless you have your diet and lifestyle utterly optimized, the marginal benefit they confer will be too small to be very noticeable.

ebola
 
All true, it's a very subtle drug. It has a much wider pharmacological profile however and showing decent promise in clinical studies being a neuroprotective, antidepressant, anticonvulsant, and anxiolytic agent.

Where it really excels IME is in combination with stimulants, or benzodiazepines. There isn't much about it on bluelight except this thread, so I thought I'd throw it in. I certainly think it lives up to its historic reputation.
 
All true, it's a very subtle drug. It has a much wider pharmacological profile however and showing decent promise in clinical studies being a neuroprotective, antidepressant, anticonvulsant, and anxiolytic agent.

Where it really excels IME is in combination with stimulants, or benzodiazepines. There isn't much about it on bluelight except this thread, so I thought I'd throw it in. I certainly think it lives up to its historic reputation.

Also, what dose/standardization do you take to achieve these effects?
 
Due to the lack of standardization in herbal medicines and alternative medicines in general, it's difficult to recommend a dose. If you buy it from a reputable manufacturer, just follow what it says on the label.

I personally started at 100 milligram capsules x 2 daily and eventually ended up at 200 milligrams x 3 daily.
 
Deprenyl is fine combined with hydergine. IMO they are best on their own, in which case hydergine is better at high, isolated doses and deprenyl at lower, short-term regimens (effects will manifest, be patient), 3 week on-cycles are ideal.
 
What are you hoping to accomplish with this -that is, to what end are you increasing 'neuroplasticity' and 'neuroregeneration'?
 
Think about synaptic function and an addict.. so many synaptic pathways lead to use.. and so many other portions of the brain have been altered or damaged.. just looking for chemical ways of facilitating the neural regeneration and plasticity in the quickest way possible, in an attempt to make the chances of an addicts recovery greater, the time period of recovery shorter, and their journey on this path more enjoyable. I believe meditation, general brain workouts, and select sensual stimulation.. coupled with any chemical advantage is a good way to start.

Glucose use obviously showing activity..
http://www.thecleanslate.org/wp-content/uploads/2010/09/volkow-brain-scan.png
brain1.jpg

1335784393_45845800.jpg

thes picture are just a representation and were picked at random of image search.

just found this and it seems others think so as well.

[qhttp://www.psychologytoday.com/blog...201302/neuroplasticity-and-addiction-recovery




Thanks for you interest sekio and thanks for anything anyone can add.

EDIT: I also link this thread to allot of drug addicts and heavy users seeking advice.
 
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