I've been using 10mg doses of 4-aco-dmt along with super sub-threshold doses of 25i-nbome (50 mcg, yes less than 100mcg)...for amazing trips...very similar to low doses of acid (100ug)....music sounds incredible, so good in fact that I spend hours of each trip just listening to new music, it is very mystical, euphoric, mind-manifesting, jeweled dmt-like visuals, incredibly colorful and emotional, i enjoy 450mg of mescaline all by itself once a month, but take these mini-4-aco-dmt combined with 25i trips at different time of the month to enjoy music for many hours, things become "new and exciting" just like with acid or dmt, A+ experience, top notch.
I took 10mg of 4-aco-dmt along with 50mcg (yes, that is only 50 mcg of 25i) and 25i-nbome...and it does indeed rock at these dosages...it is quite a remarkable trip at this dosage...the 50mcg of 25i-nbome is "just enough" to "light up" the 4-aco-dmt workspace....serotonin firing is still shut down by the 4-aco-dmt (which is what we want)..the intensity of all the colors is quite intense....my favorite thing to do on this combination is just listen to music for hours on end....really very nice indeed. I save 450mg of mescaline for a real deep trip once a month, but this combination is like a small "mini-trip" i can take on a day off inbetween....it is really quite close to acid in all it's effects...i've always thought the visual 5-ht2a agonism of 4-aco-dmt has been quite low, but it can be corrected with just the teeniest tiny dose of 25i-nbome (and this was not a typo, that is 50mcg of 25i, which is less than 100mcg of 25i-nbome!)...this is quite a perfect trip in and of itself....100% mind manifesting, the 25i-nbome adds a euphoric edge, visual intensification, human psychological insight, emotional connectod-ness....there is absolutely no vasoconstriction felt anwhere with this minute dose of 25i-nbome added....the heart or pulse rate could be felt picking up for about 5 minutes when the 25i kicked in at about 45 minutes after laying it down on the tongue...but even this slight pulse elevation quickly died down in no time. Remarkable combination at this dose....reminds me so very much of a 100ug acid dose, these 2 RC's when combined correctly, is truly out of this world mystical mind-manifesting glory.
a warning to be careful to not allow the 25i-nbome to be very high or else vasoconstriction might could set in to some degree...I had better explain the importance of the 4-aco-dmt to remain a good dosage and why i believe the 25i dosage should be extremely light...
Mixing in only 50mcg of 25i-nbome with the 10mg of 4-aco-dmt allows the 4-aco-dmt to be the star of the show, the 5-ht2A agonism from the 25i-nbome is never allowed to "overpower" the more important 5-ht1a, 5-ht1e, 5-ht1d, 5-ht7, 5-ht6, receptor agonism provided by the 4-aco-dmt. this allows "serotonin firing" to still be shut down by the 4-aco-dmt, which in turn allows the 4-aco-dmt molecule to act as a replacement for serotonin, LSD and mescaline also shut down serotonin firing....this happens because they too only allow 5-ht2a agonism to remain very low on the scale of receptor agonism, allowing 5-ht7, 5-ht6, 5-ht1a, d, e, etc. to remain the star of the show, this is needed for a spiritual mystical experience...these 7, 6, and 1 receptors make up over 80% of the brain's receptors, and they shouldn't be overpowered by 5-ht2a agonism (from the 25i-nbome) or else you end up with trips given by synthetics like 2c-e, DOI, DOC, DOM, 2c-i, etc. etc.
these natural psychedelics including the semi-synthetic LSD are precise molecular keys which all hit the more important 5-ht1a, e, and 7, 6 receptors with greater force than 5-ht2a...whereas if you study the synthetics made by man they all allow 5-ht2a to overpower everthing else, which gives visual psychedelics with little to no spiritual meaning, and meaning-less visuals, ridiculous or empty types of mental states with no spiritual significance, no archaic or meaningful visuals, etc. What I am doing with the 25i-nbome is allowing the 5-ht2a to rise only so very slightly so that it does not overpower the other important receptors that 4-aco-dmt hits, similar to LSD which allows 5-ht2a agonism to be only "8th in line" behind other more important brain receptors which make up most of the brain. I've studied Ray's receptor project data for several months, it all makes sense when you compare the classic psychedelics to the synthetics.
The tiny amount of 25i-nbome that I used only "lit up" the 4-aco-dmt workspace similar to how LSD does the same with all the other receptors before it in strength. It is a remarkable experience very similar to acid in effects, so similar in that it is mystical, brightly lit work space, euphoric, very spiritual, completely able to move around and not be sedated by the 4-aco-dmt, very emotional and colorful, with meaningful visuals and thoughts, 100% mind-manifesting. If the 25i-nbome becomes too high however (above 100ug or so)...then the quality of the trip dramatically deteriorates as the 25i-nbome 5-ht2a agonism overpowers the importance of the 4-aco-dmt...becoming nothing more than a synthetic poor quality trip.
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