• N&PD Moderators: Skorpio | thegreenhand

The Big and Bangin' Pseudo-Advanced Drug Chemistry, Pharmacology and More Thread, V.2

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The last molecule you displayed is an ether, not an ester, so esterases cannot separate the 2 molecules. The P450 system probably wouldn't be able to either.

With the 6-position substitution place ethers (at least short ethers that don't displace the rest of the fit of the morphine derivative from the mu-receptor site) as shown, it doesn't need to be cleaved to be active, check out heterocodeine.

The bentley compounds have alcohols at the 7 position (7 alpha-oriented), so having a menthol which is a complex alcohol as an ether on the 6 position with one of those would be interesting, wonder if it'd fit into both mu sites & TRPM8 receptor sites, and how it would attenuate kappa opioid receptors since menthol affects that too.
 
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