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I Like to Draw Pictures of Random Molecules

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Limpet_Chicken said:
plus you can watch porn with dogs mounting and shagging girls doggy style, missionary style any style a dog will to do a girl, believe me, see it and you'll watch it for hours on pramipexole. And get off repeatedly every minute or two.
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I find it rather striking how some most otherwise very intellectual / articulate e.g. well spoken individuals, can be at times seemingly unable to convey the earnest confessions of their own utter abject debauchery (regarding extra-curricular hobbies pivotal to hedonistic, vulgarly epicurean, endeavors)

I mean, the language immediately reflects the proportion to which the candid broaching of the subject might be stereotyped to libelous adverse ad hominem refinement of your character. Even in admittance of such thing in a frank way, can't we approach this too, like scientific minds that are quite literal about what it is they are engaging in? Bestial trans-species coitus for auto-erogenous attempts at higher plateau of subjective crossing of the taboo, etc.?
 
Bagseed said:
Pomzazed said:
double bond can migrate there in acidic condition, styrene-type structure is very easy to get protonated,
after protonation and de-protonation, db has 2 site to go, one to original, other to the enamine.
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I am not sure that I follow... you mean that the benzylic carbon will be protonated I guess? but how will that turn the sp3 carbon at the 2-position if the butane chain into sp2. can you clarify the mechanism?
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@Pomazazed: is that what you mean?

cpp_zps3tjviusd.png


You're absolutely right but only in strongly acidic media. Could it happen in stomach acids? ... who knows? I see that happening very easily with the corresponding ketone though (keto-enol tautomerisation) which will result in hydrolysis of the corresponding enamine. Now that you mention it, it may be the reason why cathinones like mephedrone methylone...etc are rather unstable in aqueous media; probably get hydrolyzed via similar enamines formation to give the corresponding glyoxal and amine. (couldn't catch time to draw same things with cathinones but you get the point! ..
the styryl seems to be more stable than the cathinones at least in buffer.. but who knows unless synthesized and tested..
 
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Yes, that is absolutely what i meant; but on my second thought; the amine might make this styrene much more acid resistant.
N would get protonated real first; and getting doubly protonated cation is not so much likely.

This may still happen in conc. HCl i suppose, (12M)
Acid stomach is pH 1-2; and 1M HCl pH=1; so its 12x to 120x more dilute than conc HCl; idk if this still happens.
 
How, may I ask, can I libelously ad-hom MYSELF?

One can only libel another, you cannot, as I understand it slander myself. but yeah, put me in a room with a horny spesh chick (preferably classic autism rather than asperger's, but either will do and BE done=D, I've known a Rett's girl who's a friend and cared about deeply too who is one of THE most shockingly, amazingly, stunning and eath-shatteringly GORGEOUS, sparky, fiery, and so damn smart. Not to mention she's got a snark on her that is positively a massive fucking turn on to see being used to ensnark the vile curebie filth such as the likes of autisn squeaks), a dog she's willing to take it up the arse from whilst I cervix-fuck her senseless, give me enough opioid not to be in withdrawal, my antiseizure med (chlormethiazole, gabapenturd is sort of doing the same thing but I hate it and am trying to get off it), some clonidine for me to keep from a nasty rebound, just a low dose as it can be counterproductive to the erotic then toss is a box of pramipexole pills, and for the girl at least, some ondansetron plus buscopan if she's new to glepark, of course I'd not dose the dog, because I HATE abuses of animal welfare. And you can betcha that if the girl is willing for videotaping, and of course there would need be a mask to cover my eyes and identifying features so that I'd not actually get prosecuted for the kink or for being the naughty autie clandestine this, that and t'other by way of non-autie/aspie/Rett's&canidae specimen transspecies hedonistic shits'n'giggles, the kind of thing that I often post in ADD about that of course the filth probably like about as much as they'd like my tagteaming a Kanner's girl with a dog. Now I don't like the cheap mechanically processed 'meat' product, but that'd bring a new entire sense of meaning to 'could go for a hotdog'
 
IMO there is very little similarity between cyclohexyl and phenyl aside from similar size and shape, but other than that both sterically and electronically they are different, so if the interaction via an aromatic ring in a given compound is crucial for it to bind at all, then there is no way cyclohexyl could substitute for phenyl. The case of propylhexedrine is rather a rarity among simple compounds bearing basically one or two functional groups through which they can bind via dipolar interactions, and it is much less potent than its phenyl counterpart, methamphetamine. As for secondary or tertiary interactions that impact binding, I imagine that the size, shape and environment of the site/pocket that can tolerate cycloalkyl as well as aromatic rings is likely crucial, if such a group is just a filler that is required only not to disturb the binding, then as long as it fits in/can locate itself, it could be either aliphatic or aromatic.

In case of psychedelic phenethylamines cyclohexyl doesn't work because the stacking interaction must be crucial likely as well as the right orientation of the methoxy groups on the ring.
 
most importantly, as adder said, no pi-stacking is possible with a cyhex, as opposed to benzene, so if that interaction is needed for activity, it's already bad. furthermore, benzene is perfectly planar, while cyclohexyl isn't, and can also exist in more than one conformation, which makes things more complicated.
 
It is a stimulant, not a psychedelic. Are you familiar with propylhexedrine?

2-methylaminopropylcyclohexane.png


PROPYLHEXEDRINE
 
Dresden said:
It is a stimulant, not a psychedelic. Are you familiar with propylhexedrine?

2-methylaminopropylcyclohexane.png


PROPYLHEXEDRINE
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I know, the comment wondering about psychedelics was unrelated to propylhexedrine..

Also reminds me of DMAA which is an even more abstracted aliphatic analogue, but also has effects that aren't really that typical or similar anymore, in any case I hated it.
But yeah propylhexedrine sounds alright actually, never tried it, no idea if it can be found easily in the netherlands.
 
Frankensteins tryptamines ;)

Reminds me, how I'd love to try Shulgins 3,4 and 4,5-MDO tryptamines.

Edit: Just occured to me, what about changing the 4-hydroxy to 4-sulfanyl in dimethyltryptamines? It's so obvious, someone must have done it already.
 
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