• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Stimulants The Buproprion (Wellbutrin) Megathread

Right cheers, I know what you mean about the bitchiness, some drugs make me very snappy. Im not gonna be taking this stuff when i start reducing benzos as there is an increased risk of seizures. Just waiting to see what effect it has on me today, so far im just feeling like theres a cloud forming in my brain or something. Fuckin weird. It may not suit me.
 
it worked the first day for me..noticeable 'stimulated' effect, more energy but it didnt feel like clean energy, it felt like stimulant energy if you know what i mean..definite increased libido for the first few days but that went away as did the increased energy and motivation...made me anxious too and that didnt go away..YES i also noticed a weird 'brain block' effect to it and that sucked and didnt go away..i got off and feel better..
 
Bupropion is a NDRI antidepressant, like every drug it start working as soon as the drug is absorbed by the body, but the full effect is not reach until 2-3 weeks like most antidepressant.

I tried Bupropion when I was in highschool but I dont remember the effect very well but it was mild.
 
Ppl IV These in my area....they claim it feels like coke or ritalin......sOmething to do with dopamine release and seratonin re uptake I'm guessing???
 
bupropion is NOT abusable!!! DON'T EVEN THINK ABOUT IT!!!

people have used it in prisons to substitute cocaine due to the stimulant and numbing properties it has, but abuse ends up in a very uncomfortable stimulation and anticholinergic hallucinations due to antagonism of the nicotinic ach receptors.

for medical use it is the best "antidepressant" i have ever tried, it provides a very calming effect coupled with motivation and energy after just 3 days, which peaks at about 2 weeks. my life was coming together beautifully when i was on this med, however i can no longer afford it and i'm stuck with shitty ritalin, which although is more euphoric, doesn't give me the same content-with-life feeling, and tolerance builds extremely fast to ritalin..

i'd switch back to bupropion given the chance, however i'm sure it won't do anything for me seeing as my dopamine systems are probably already down regulated by the ritalin (which i'm only using medically).
 
oh yes also i had sexual proble ms while on welbutrin...they claim it helps people in this area but it hurt me...increased libido for a few days but then it became impossible to perform sexually..
 
Just started 150mg SR 2x a day 2 weeks ago. Helpful with opioid PAWS, at least, it gets me out of bed. Not as helpful as gabapentin, but it does help a little. My working memory feels off, which is the reason I dropped it the first time I was prescribed it. At this point though, I think it helps enough that i'll continue. It's dropped any nicotine cravings, and now I can sleep even when I haven't had nicotine for 6 hours (I used to chew 2x4mg gums before bed). Never really intended to quit nicotine, but it'll save money.

Edit: So far I haven't really found it too effective as an antidepressant, but hardly any side effects. In the past I found phenelzine to be really effective, but with too many side effects for me.

If this fails I'll probably go to deprenyl as an AD. If only the U.S. had moclobemide.

Also, if anyone has tried Sunifiram with bupropion I'd be interested to hear about it. I took 10-15mg sublingually while on a 150mg dose and it actually felt somewhat recreational and speedy?
 
Last edited:
I took it before bed once and it gave me most extreme night terrors oof my life.

Evil bunnies were spawning under my blankets and I could feel them.. And I would wake up... Right when I closed my eyes they would spawn again... The my blanket started straggling me and I stood up took 5 steps and felt so weak I collapsed and woke up in the kitchen


Flushed em down the toilet
 
ive also noticed they seem to help with opi w/ds. However i also took 2 immodiums/loperamides for a stomach upset, so cannot as yet be sure what had the greater effect. For the moment ive only taken the WB once, i dint really like the on edge, slightly pending feelings of doom and worry it gave me, so am sticking to modafinil for the moment as an adjunct to mirtazapine. The mirt is beginning to work by itself, so i may be able to start taking less and less modafinil. I already do a roughly 4 days on 4 days off thing with modafinil. Dont wanna get too dependant on it, and i dont feel that i need it all the time. I ordered the stronger pills (300mg i think) as they are better value for money, but i halve them as 300mg all at once is really too much for me.
 
From my experience in working in this region's largest methadone/Suboxone/addictions clinic, I can say that misuse/abuse of buproprion is actually on the rise. It used to be somewhat of a rare occurrence and localized to very specific populations, but it's becoming more prevalent in this region. We actually had a patient come to the clinic seeking help for a "buproprion addiction". 99.99% of the time, people that misuse/abuse it end up having severe tonic-clonic (grand mal) seizures and the patients that I can think of that abuse it on a regular basis have had numerous seizures, many of them ending up in ICU for quite some time and all show signs of some brain damage as a result of repeated seizures. However, when I was recently locked up in the local county jail, buproprion abuse was significantly more common than out on the streets. A lot of guys in the jail would abuse it for a stimulant-like high, considering that the jail was very stringent on what they'd give inmates and a lot of guys were desperate for any kind of buzz. Hell, they wouldn't give me my prescribed benzos or any of my other meds until about 4 days into my stay there, despite the fact that the jail received confirmation from both my pharmacy and my doctors that I'm on those meds in addition to actually seeing the pill bottles with the meds in them. Anyways, in County, more than a few guys also abused things like doxepin (which is really dangerous, considering that it's a tricyclic) and "bug pills" like olanzapine and Seroquel, as the jail had a tendency to hand these out like candy to a lot of guys on every single range (cell block) in the joint. I suppose it's a futile attempt on the jail's part to try and keep things more placid (needless to say, it fails miserably). Mind you, there were still plenty of more mainstream drugs that the more clever and enterprising inmates had managed to sneak into the jail through various methods (not just by hooping them, either ;) ).

My point is that there seems to be an increase in people misusing/abusing buproprion, despite the incredible danger of doing so. Abusing it almost always results in a seizure, and I can recall a number of people dying from abusing it. They went into status epilepticus and never made it out or had fatal cardiac episodes. Others made it out of status, but were left in a permanent vegetative state. The bottom line is that it's a medication that's a whole hell of a lot more dangerous than one would initially assume.

I thought it'd just get my 2 cents in about buproprion.
 
Bupropion is a NDRI antidepressant, like every drug it start working as soon as the drug is absorbed by the body, but the full effect is not reach until 2-3 weeks like most antidepressant.
NDRIs are stimulants. bupropion is just an especially weak one with an exceptionally bad ratio of side effects to effects to effects, that's why it is considered "not abusable". furthermore, it is well-known that stimulants lift mood, self-esteem and alertness (already the nazis knew that and gave their soldiers "pervitin"). for some strange reasons (most likely a collecitive psychosis), our society does not accept drugs which increase mood strongly or even cause euphoria; that's why the exceptional inefficience of bupropion was used in its advantage by some clever marketing specialists, who just relabeled it an antidepressant (which in no rational way can be justified). this move was as ridiculous as it is genius (look at all the money "wellbutrin" makes; it's almost as reaching the Alchemist's goal of turning shit into gold!), and it only worked because of the funny fact that almost all medical doctors have no clue about psychipharmacology, and this gets in no way better when one only considers psychiatrists (which raises an interesting question - what do they learn at all in their long training?). because of their ignorance they just apply the same rules they have learned for SSRIs for any drug (no matter what type), if only "ANTIDEPRESSANT" is written in big letters all over the package. they then life in the absurd conviction that by this labelling all basic laws of psychopharmacology are set out of order (this is e.g. also the reason they just refuse to believe that SSRIs develop tolerance just like any other psychoactive drug, which they also observe with almost every long-term user, but they have obviously developed double-think like techniques to keep this fact out of their mind).

yes, after swallowing the first pill it will take some hours to kick in. this is because of the simple fact that almost all medical formulations of buproprion use some extended-release mechanism. and yes, the effect will be a bit stronger on the second day, but again this has nothing to do with the complex regulation mechanisms that cause the "therapeutic lag" of SSRIs, which are still not fully understood (as the action of the SSRIs in general), but is the simple result of the fact that the half-life of bupropion is long enough that a significant amount of the pill from 24 h ago is still active. it would not be different with any other long-acting drug, like, e.g. methamphetamin; the only difference would be that with meth you would have more fun, and probably the destructive side effects would also be worse (but just a little). (of course this increase in action only goes over some days or maybe weeks until tolerance sets in).

fun exercise: try googeling "wellbutrin psychosis" and "wellbutrin destroyed my life" - but wait. first give an estimation how many hits google will give you.

PS: another especially funny / shocking / tragic aspect (depending on your viewpoint) of this "medication" I have heard and read in slight variations already several times: some physicians are even stupid enough to prescribe this toxic waste to anxiety patients. every sentient being can reckon that giving such a person amphetamines will worsen their anxiety, but because those doctors reason pointedly, that which must not, can not be, they either declare this to side effects that will vanish with longer intake (causing them to worsen even more), or even increase the dosage of the buprpopion even more (which of course worsens the symptoms even stronger)...
 
our society does not accept drugs which increase mood strongly or even cause euphoria

Tell this to the idiot pediatrics that prescribed me Methylphenidate when I was 10 years old and completely ruined my childhood. Also to those in US that prescribe Methamphetamine to childrens.
 
Last edited:
Just wanted to add one thing about BP, having used it as an antidepressant for ~15 years (really! and after much acclimatization my dose is 600 mg/day) -
I find it amazingly effective withdrawal aid for amphetamine/crystal meth habits. No, it doesn't get you "UP" very well- so little or no re-inforcement for dosing, etc.. But it does remove that "something is deeply missing in my brain" squishyness and fuzz from neurotransmitter (DA/NA) deprivation.

it has been a real life saver in this regard. Never found it useful for opiate withdrawal.

On the other hand, it strongly interferes with action of amphetamines.... so you must decide "adderall or wellbutrin?".

From what I've been reading on erowid, though, it can be dangerous when combined with 4-substituted tryptamines.
 
Last edited:
I am rx'd Wellbutrin for mood and depression. I felt the effects of the drug the very first day I took it--although it was slight, it was certainly a stimulant feeling. This stimulant feeling leveled out after 2 weeks or so.

I've been on it for 8 months. It is the first anti-depressant that has worked for me (I tried prozac + lexapro years ago). I am already an organized and healthy person, but Wellbutrin stabilizes my mood and gives me the energy to do the things that produce natural endorphins--the activities that I lose interest in when I am in a depressed state.

It is really interesting to see how the drug affects people's brains differently--the range is wide and pronounced. The stim effect was mild for me, and I am on a high dose (300mg). But I have seen others take 150 mg and grind their teeth, bounce off the walls, etc as if they had taken adderall.
 
Last edited:
Wow what's with all the hate. I love bupropion it's wonderful helps loads with my depression and ADHD- and substance abuse haven't had a lapse on it yet *knock on wood*. I also take suboxone, caffiene, nicotine, and trazodone daily. Bupropion has done wonders to make me more functional and happy.

And to the guy rambling one about how it's a conspiracy and just a shitty stimulant. It upregulates dopamine and norepinephrine even after use has ceased, I'd take that any day over classical stims long term down regulation.
 
A friend of mine has depression, can't move and is bedridden. Showering, laundry and basic tasks are huge endeavors. Anyway, they have been on Wellbutrin 300 XL for 5 years. When they first started taking it, they were able to move and got a FULLTIME job. It was awesome! They were functional!

Unfortunately, over time Wellbutrin became less effective. So, they have been looking for a replacement or something that will synergistically work with Wellbutrin making it effective again. Anyway, they have tried Abilify (manic shopping and got into debt for the first time) and Nuvigil (uncontrollable anger) Effexor (bedridden after an initial good response).

They are no longer working. As a very desperate attempt, today they tried crushing the Wellbutrin tablets (NOT recommended because the likelihood of seizures increases dramatically) and it's temporarily helping them. But, it's unlikely that this will last long.

Questions:
Since Wellbutrin is no longer working, any ideas about other medications, protocols or approaches that might be helpful? What about Zyban? What about neuroprotective medications? Nootropics? Racetam compounds? MAO-B inhibitors or COMT? Protriptyline (Vivactil), which is an energizing TCA (tricyclic antidepressant)?

This is an interesting read about L-Dopa and Wellbutrin --> https://www.drugs-forum.com/forum/showpost.php?p=955874&postcount=4

Thanks for your help!
 
Last edited:
Coffee, nicotine via ecigs or gum, buprenorphine (only available for opioid addicts unfortunately), maca root, l-theanine. trazodone and sleepy time extra tea before bed. hmmm I could probably think of some others.... I'll ponder it
 
bupropion is NOT abusable

It is nonetheless abused in Canada according to Wiki and I seriously doubt the practice is restricted to our neighbors. That said, abuse is rreported to be so risky and potentially unpleasant that the perspective constitutes an effective deterrent. Effective enough for me in any case, I was never tempted to abuse my prescription. On a brighter note it has the benefit of lowering euphoric threshold of methylphenidate (for me and other users I know) which is only a blessing to those who are aware of this and lower their MPH dose accordingly, otherwise their usual ritalin hit may lead directly to the unpleasant effects normally associated with the comedown, skipping the rush entirely. I was initially unaware of this and it happened to me but I had put the blame on my agitated state of mind over marital issues I was experiencing at the time.

people have used it in prisons to substitute cocaine due to the stimulant and numbing properties it has, but abuse ends up in a very uncomfortable stimulation and anticholinergic hallucinations due to antagonism of the nicotinic ach receptors.

That's why I only use it as prescribed despite my 30 years of eager stimulant use for various purposes. I may not be that wise for a middle-aged man but I'm very cautious in this regard and treat any drug including pharmas as I would RC's: research, research and more research must precede consumption.

for medical use it is the best "antidepressant" i have ever tried

Same here, in fact it's the only antidepressant that ever brought me a mood lift, others only had untoward effects ranging from annoying to unbearable, or no effect whatsoever after months of taking them. On comparison the effect of a 150mg EX dose taken in the morning is very similar to that of taking one 10mg IR Ritalin tablet 3 times a day. The timing of the XR formula appears to be punctual (timed for release at given intervals) rather than sustained. This is very mild but nonetheless noticeable and appreciated. On me it has the same attenuating effect on tobacco intake as Ritalin but that's due to my focusing on other stuff and "forgetting" to light up, I don't notice any sudden change of taste or smell on the cigraillos and occasional cigarette I smoke, compared with ethylphenidate which makes tobacco smoke smell funky and gives my Polo Blue cologne an aroma reminiscent of Eau De Skunk. Wellbutrin also tames cravings for stims in general. I still use them but at considerably lower doses than I used to and less frequently.

I understand that many members posting in this thread are frustrated that a cathinone congener is unable to provide recreational effects but that's to be expected from an engineered molecule designed to provide a moderate mood lift as opposed to a more intense stimulant rush, even when abused, or achieving it only at an unacceptably high risk to one's health and/or sanity. For my part I consider us lucky that the manufacturer ever managed to get an amphetamine-like substance approved as an anti-depressant despite the initial reluctance of the FDA. On me as on you it does the job it is meant to do which is more than we can say of the esoteric concoctions it competes with, few of which being any less toxic, quite the opposite: Wellbutrin's side effect profile is rather mild for an antidepressant with proven efficacy. Some critical articles claim that those effects are entirely due to direct CNS stimulation but I fail to see why, if such would be the case, this would in any form or shape prove detrimental to therapeutic benefits. At least it explains how it works and has immediate tangible effects.

I don't personally liken those effects to those of caffeine. I enjoy a strong cup of joe as much as the next guy but I get a different buzz from it. I can tell amphetamine/cathinone type-induced stimulation from that associated with caffeine no matter how subdued the former may be as long as it's as noticeable as, say, 10mg ritalin is to a stimulant-tolerant individual. That's exactly what I get 3 times a day from a single 150mg dose of Wellbutrin XR 150mg. Or is that XL? Too comfy to get up and go upstairs to check the label, sorry.
 
Top