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Altering Adderall effects by Vitamin C dose control: Plausible?

brandnewvibe

Bluelighter
Joined
Apr 17, 2005
Messages
6
Imagine a person that ingested almost zero Vitamin C from during and 10 hours before the course of their Adderall experience.

Is it possible that this person would experience the Adderall differently under these conditions versus a high-dose Vitamin C regime?

It seems possible that this could be; Vitamin C is required for the step converting Dopamine to Norepinephrine. It could be that having a limited amount of Vitamin C around to use in the conversion process, the large amount of dopamine released takes longer to be converted.

Is this obviously impossible, or very unlikely, due to something I'm not aware of?
 
By the time dopamine is being converted to NE or whatever it is already back in the cytosol of a cell. Thus it is no longer signalling so a lack of vitamin c wil do nothing in this case.
 
I have heard taking vitamin C before speeding can create a "clean" speedy feeling, I did this the other day and I have felt this "clean" feeling as well.
 
TruthSpeaker,
It's interesting you should say this, because the reason I posted this was:

Since starting AD, I had been religiously keeping Vitamin C out of my diet*, because of everything I had read that said that it caused acidification of intestinal content, resulting in lowered absorption and retention of the AD.

However, I then learned that it's only the "Ascorbic acid" form of C that causes this acidification, and other forms of C (the X-ascorbates, e.g., magnesium ascorbate, sodium ascorbate, niacin ascorbate) caused no acidification.

I realized that I had some magnesium ascorbate powder lying around, and the following day I took some of the mg-a (including ~800% RDA of Vitamin C) about an hour before dosing the AD.** I also took more at about +T3:00 after the first 30mg of AD.

My experience was markedly different from any I had had before. First of all, there was very little or no euphoria. I don't normally experience a great deal of euphoria from AD any more, but still usually do get mild-to-moderate euphoric effects that last for about an hour, from +T0:30 to +T1:30. This time, there was almost none, if any.

Second, I felt totally "clean" throughout my body. The best analogy I can think of is the feeling one has about an hour after completing a work-out, once the peak of the endorphin high is well past. For some reason "clean" is the absolute best way to describe the feeling, but this is somewhat unhelpful I realize because it has very little explanatory value. That is, someone else who's expereienced it may think "that's exactly it, I know what he's talking about," but someone who hasn't will probably think it doesn't really mean much to them.

Third, this was by far the greatest improvement to my ability to concentrate/ "momentum" that I have experienced from AD. It was the first time I've experienced a "time-warp"-type effect: I was drawing, and all of a sudden noticed the clock, and it was an hour later. I had been totally lost in the activity. It was almost to the point of overfocus, and over-inertia: I would be reading something, and realize that I was really thirsty, and wanted to get a glass of water. But there was this underlying drive to "stick to" the main task of reading, and I would keep going with it even though I really was thirsty and really did want to get a glass of water right then. It would take about two or three more instances of my thirst/desire to get water "popping into my head" before it got to the point where I more or less thought "this is ridiculous!" and with what felt like great effort, stopped reading and went to get water.

The reason I asked about the possibility that C causes dopamine to stick around longer and norepinephrine to be produced less was the combination of my experience (less euphoria, much more focus) and my (clearly very limited) knowledge of neurochemistry. It seemed to "make sense" on both levels. Although as posters have already pointed out, it seems unlikely that this is the case.


*I was doing this only before dosing/during the experience. I had, for example, been taking a multivitamin including C, but only late at night, well after the last dose of the day had tailed off.

**I'm fairly certain the main variable here was the Vitamin C, because I have been dosing mag before/during the AD experience all along. When I tried the mg-a, I accounted for the amount of mg I was getting from it, and took less mg-gluconate, so although it's possible my different expereince after the mg-a was due to differential absorption of the mg-a vs. mg-g, I believe it's unlikely because the amount of mg from the mg-a was very small.
 
Glad to see it worked out for you.


From what I know, ascorbic acids causes amphetamines to be digested in membrane faster, this is why many people who don't like XR pills crush them up and parachute them in lemon juice concentrate. Since you have been taking Vitamin C before dosing, it is possible that this has caused the amphetamines to absorb faster, creating a faster rush, but also more short lived, with a harsher comedown.

The magnesium would also help lower stress and reduce jaw clinching while on amphetamines, not to mention lower the hypertension. The reduced norepinephrine levels secreted by the body is most likely due to the magnesium you have consumed. Magnesium also helps in keeping amphetamine tolerance down.

Different combinations work for different people, good to see you have found what works.
 
*shrug* who knows... vitamin C has so much mythology attacthed too it.. who knows... Just incase anyone is doubting brandnewvibe claim thatdopamine-->noradrenaline is a vitamin C dependent process, He is at least in part right, dopamine beta-hydroxylase is a member of the ascorbate-dependent monooxygenase family, it's also copper dependent too though, but I wouldn't suggest munching copper.

Ultimately, I can't quite see the logic though, why would eating vitamin C, which theoretically could enhance dopamine break down (even extracellularly, as dopamine beta-hydroxylase is secreted), enhance your high? If anything it should increase body load....

If vit C really is enhancing your high, it's not doing it that way.
 
^^^ He is saying that he will not eat vitamin C. Although you probably have scurvy before you kept DA-B-hydroxylase from having enough ascorbate to function. Who knows.
 
To be clear, the "new" experience I talked about was after taking C for the first time. (I had up until then been avoiding it). My claim is that I felt less "high," (in the sense of euphoria, sense of well being, and altered sensory perception and processing) but that the "therapeutic" effects were magnified. Also I had the mental and physical "clean" feeling referenced by another poster, and I had a much smaller comedown. Perhaps it's because there were fewer of the "high" effects that I noticed the more subtle effects.

Also, I was not taking ascorbic acid, but rather magnesium ascorbate, which is pH neutral.
 
Ascorbic acid will cause a slight reduction of plama pH, so faster clearance by the kidney, whereas sodium ascorbate will have the opposite effect (although it'll be hardly noticable)
 
I am new to bluelight and found the website while reading possible interaction(s) taking vitamin C before, with, or after taking adderall. I am prescribed 30mg generic adderall 2x daily. I have found the answers I search and here is how. It was only a few days ago that I awoke very tired and took three 30mg adderalls. I had never taken this much adderall before in one swallow. Needless to say I became very agitated very quickly. So I went to the web and began to research how hospitals treat amphetamine overdose as well as others' experiences when taking too much adderall. I read everything that I found on Vitamin C (in ascorbic acid form) and their interactions with adderall because I keep a bottle of 500mg Vitamin C ascorbic acid on hand. After reading that the ascorbic acid can reduce and even cancel out the effect of adderall I drank a tall glass of water and chewed up three of these Vitamin C 500mg tablets.
In the first 30min my anxiety reduced.
After 45min I felt slightly dizzy but much better.
After an hour and a half I felt as though I had just came off a slightly bad trip, but better. After 1hr and 45min it was as though I had taken nothing.
I discussed this experience with my pharmacist. She nodded her head and said she could have told me that taking the concentrated vit c in the ascorbic acid form as well as many citric acids can lessen and even prevent the absorption of the medication. Also, she informed me that even after the amphetamine salt has been digested and entered the blood stream the acidity of the ascorbic and citric acids have the potential to ruin the medications effects. Hope my experience helps but is not advice...
 
It has been noted many times with different drugs that taking acids or bases with certain drugs can interfere or potentiate their absorption. There are many drugs that recommend that you do not take calcium or other buffers within 2 hours of taking the medication. In addition, there is some anecdotal evidence (as seen above) that acids can affect the nature of dosing. Unfortunately, not enough clinical trials are done to analyze the effect of acids or bases on drug absorption. Usually all they do is check to see if it is absorbed at all in the presence of buffers. Then they check for CYP enzyme interactions and then check for interactions with the big problematic drugs (cimedine, phenytoin, carbamazepine and phenobarbital) and send it off for marketing. The cover story from the May 2010 episode of the scientist talks about new techniques they may be employing to help unveil more drug/supplement interactions. You might still be able to read it at www.thescientist.com.

Even if you can't read that episode online anymore, you guys would probably like the scientist. It is definitely the best written science magazine out there, and I have read a lot of science magazines. I mean, it reads like good journalism as opposed to figures parsed together with some unintelligable writing, (usually written by some guy who knows English as a second language). You can read the current episode on the web.
 
dopamine beta-hydroxylase is a member of the ascorbate-dependent monooxygenase family, it's also copper dependent too though, but I wouldn't suggest munching copper

chlorophyllin has a modest amount of bioavailable copper (this is CHLOROFRESH in the US). I've been meaning to buy some for a while for other reasons.

One thing I don't understand about some responses to this thread, after you get past the absorption & pH thing: I thought the conversion of dopamine to NE was essential to the therapeutic effect of amphetamine.
 
The best reason to take antioxidant vitamins along with stimulants is to reduce oxidative damage that is done. If a person is taking stimulants they are likely losing lots of sleep, too and this will cause a buildup of free radicals. I read a journal abstract somewhere that showed massive doses of iv antioxidants blocked the neuron damaging effects of mdma. Also another abstract about rats that were being dosed with methamphetamine, one group with vitamins, one without and there was a significant reduction of damage. I don't have the links or i'd post them. Found in a google search
 
Vitamin C, ascorbic acid, most definitely affects adderall in the system in noticeable ways. Above all taking ascorbic acid directly minimizes several of adderall's negative side-effects through several of it's inherent properties, not the least of which being an increased rate of renal excretion of the drug and it's constituents.

Personally adderall is the only medication I am prescribed. It has helped me immensely in school and with general life productivity however it's side effects can be troubling. These include vasodilation (causing hands and feet to feel cold, and the penis to temporarily shrink), appetite suppression, and sleep disruption, among other things. At the molecular level adderall may also be speeding up the age process and causing some oxidative damage in the body. I also take ascorbic acid on the measure of about 10 grams daily. Since beginning this vitamin C regimen I have noticed that when taking adderall my appetite is less suppressed, the extent of vasodilation is not as pronounced, my blood pressure is lower, and when it's time for bed I can fall asleep easier. All of this occurs seemingly without effecting the positive aspects of adderall such as increased concentration and productivity.

While I don't have enough experience to recommend such a regimen to everyone I can say that taking large amounts of ascorbic acid, in addition to adderall, has improved my life on the drug. I would recommend trying large amounts of ascorbic acid to anyone interested in this experience I have had. However if your concern is increasing the life of your adderall dose in your system then you don't need to take large amounts of ascorbic acid. You should question your motivations, though, as to whether you desire the "up" feelings of adderall for the right reasons. And also make sure that you continue to take at least some vitamin C as it will help to mitigate some of the unavoidable health consequences of taking a drug like adderall.
 
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Baking soda is a much better way to alter the effects of Adderall, as my friend Drew C. McTweakface always insisted as he swirled around a solution of water and sodium bicarbonate at parties (and some day I'll get you back for stealing half my script sometime, you rat bastard).
 
^ LOL agreed. I recall bassifying myself (heh) to make dex hit harder and last longer.

As for the OP... Scurvy: the solution to all tweakers' problems =D.
 
(adderall's) side effects can be troubling. These include vasodilation (causing hands and feet to feel cold, and the penis to temporarily shrink)
Actually this effect is vasoconstriction; the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels. And I have this effect happen to me pretty bad. I got viagra - which is a penis-area targeted vasodialator and that works wonders on the penis shrinkage thing, problem solved.

At the molecular level adderall may also be speeding up the age process and causing some oxidative damage in the body.
Yeah that's for sure, it shortens your lifespan and causes pretty lasting damage, especially if you are getting heavy with your use. You get at a higher quality of life now at the price of accelerated decrepitude. I'm ok with that choice.
 
Actually this effect is vasoconstriction; the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels. And I have this effect happen to me pretty bad. I got viagra - which is a penis-area targeted vasodialator and that works wonders on the penis shrinkage thing, problem solved.

Exactly, vasoconstriction. I think you knew exactly what I was talking about. Adderall is a powerful vasoconstrictor. Do you take Viagra on a daily basis or only on days/at times when sex is likely?

Yeah that's for sure, it shortens your lifespan and causes pretty lasting damage, especially if you are getting heavy with your use. You get at a higher quality of life now at the price of accelerated decrepitude. I'm ok with that choice.

Wait until you reach the age when you are feeling those effects. I guarantee your attitude will be different. Be smart man, not clearly stupid.
 
I take the viagra only when i'm gettin it or going to have a lengthy masturbation session, maybe 4 times a week. It's kindof expensive with my shitty insurance.

I am an addict so I am stupid by default. I am powerless.
 
I just took my adderol with a water bottle filled with 4 tsp of vitamin C crystals it is 100% calcium ascorbate and non acidic. How will this effect me?
 
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